Instructor, Harvard Medical School
Assistant in Pharmacology, Massachusetts General Hospital
Description of Research
We study modulation of ion channels by general anesthetics using molecular biology, biochemistry and electrophysiology techniques. Wild type and mutant GABAA receptors are expressed in heterologous expression systems, and allosteric modulation of GABAA receptors by anesthetics such as etomidate is investigated using two electrode voltage-clamp and patch-clamp recordings. We are also interested in studying the mechanisms underlying epilepsy/seizures as well as their related complications. In the current project, we are investigating the role of serotonergic neurotransmission in respiratory arrest evoked by generalized seizures in DBA mice, an animal model for human sudden unexpected death in epilepsy (SUDEP).
Public Transportation Access: yes
Disabled Access: yes
For more information, please visit our website.
Proto magazine stakes its ground on medicine's leading edge, reporting back from the frontiers of research and practice - exploring breakthroughs, dissecting controversies and opening a forum for informed debate.
Discover the largest hospital-based research program in the U.S. and how clinicians and scientists chart new terrain in biomedical research to treat and prevent human disease and bring the latest advances to patient care
Discover what makes Massachusetts General Hospital not just one of the best places to receive patient care but also one of the best places to work.