Research Centers

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Akito Nakagawa, PhD

Akito Nakagawa researches the identification of small molecules that modulate gas binding properties of human hemoglobin at Massachusetts General Hospital.

Instructor in Anaesthesia, Harvard Medical School

Assistant in Chemistry, Massachusetts General Hospital
Research Areas

  • Physical chemistry (Development of assays for high throughput screening)
  • Biochemistry (Studies on how small molecules can bind to hemoglobin and modulate its binding affinity of gaseous ligands (oxygen, carbon monoxide and nitric oxide))
  • Medicinal chemistry (Design and synthesis of small molecules modulating gas binding affinity of hemoglobin)

Description of ResearchMy research focuses on identification of small molecules that modulate gas binding properties of human hemoglobin. Ongoing projects include (1) development of assays for high throughput screening of small molecules that modulate gas binding affinity of hemoglobin, (2) identification those small molecules from a compound library, (3) studies on how they modulate gas binding affinity of hemoglobin and (4) applications of gas binding modulators of hemoglobin for treating human disease. The projects are conducted in Warren Zapol's lab and collaborated with Broad Institute. We screened small molecules from a compound library using our developed assays and identified some small molecules altering oxygen binding affinity of hemoglobin. These molecules could be drugs for treating sickle cell disease and oxygenating hypoxic tissues.

Anesthesia, Critical Care and Pain Medicine

Gray-Bigelow 444
55 Fruit St.
Boston, MA 02114

Phone: 617-726-3030

Public Transportation Access: yes
Disabled Access: yes

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