Akito Nakagawa, PhD
Instructor in Anaesthesia, Harvard Medical School
Assistant in Chemistry, Massachusetts General Hospital
Description of Research
My research focuses on identification of small molecules that modulate gas binding properties of hemoglobin and red blood cells. Ongoing projects include:
The projects are conducted in Warren Zapol Lab. We recently identified a small molecule that increases oxygen affinity of hemoglobin and inhibits in vitro hypoxia-induced sickling of red blood cells in patients with sickle cell disease without hemolysis. The identified molecule could be a lead molecule for the treatment of patients with sickle cell disease.
Nakagawa, A., Lui, F. E., Wassaf, D., Yefidoff-Freedman, R., Casalena, D., Palmer, M. A., Meadows, J., Mozzarelli, A., Ronda, L., Abdulmalik, O., Bloch, K. D., Safo, M. K., and Zapol, W. M. (2014) Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling, ACS Chem Biol 9, 2318-2325. (ACS Chemical Biology highlighted our paper and interviewed me about the paper. This interview has been reported in ACS Chemical Biology Podcast, October 2014).