Research Centers

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Musculoskeletal Genetics and Regenerative Biology Laboratory (MGRBL)

The MGBRL is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

Jenna Galloway, PhD, Director of the MGBRL at MassGeneral, Boston

Under the direction of Dr. Jenna Galloway, the MGBRL uses genetic and chemical screening techniques to identify essential regulators of musculoskeletal biology. The laboratory specifically focuses on understanding the complex biology of tendons and ligaments, and employs a multidisciplinary approach, using different model systems from zebrafish to stem cells, to develop regenerative biology solutions to tendon and ligament injuries.

A major area of research in the MGBRL aims to identify the cues that direct progenitor cells to become mature tendons and ligaments. During embryogenesis, progenitor cell populations give rise to cartilage or tendon tissues in our limbs, head and spine. We are interested in elucidating the pathways that regulate this fate decision, expand the progenitor populations and promote more faithful differentiation into each of these lineages.

Another focus of the MGBRL is on understanding the critical factors that coordinate the attachments between muscle, tendon, and bone. By combining live-imaging and high-throughput screening approaches, our goal is to identify the molecules and cellular behaviors governing these processes. In the long term, the MGBRL aims to transform these discoveries into regenerative biology solutions to better heal and repair tendon and ligament injuries.

The MGBRL is an active member of the Harvard Stem Cell Institute (HSCI) and is located within the Center for Regenerative Medicine (CRM) at MGH. The CRM is a multidisciplinary center focused on integrating our understanding of biological processes with the development of novel clinical therapies.

Jenna Galloway, PhD, Director of the MGRBL, MassGeneral, Boston

Director

  • Jenna Galloway, PhD

Lab Manager

  • Matthew King

Postdoctoral Fellow

  • Rishita Shah, PhD
 

Jenna Galloway, PhD, Director of the MGRBL, MassGeneral, Boston

Current Research Projects

  • Tendon progenitor cell regulation
  • Myo-tendinous and osteo-tendinous junctions
  • Directed differentiation into tendon and ligament tissues
 

For research positions, please contact Jenna Galloway.

Musculoskeletal Genetics and Regenerative Biology Laboratory

Phone: Contact info below


Jenna Galloway, PhD
Assistant Professor
Center for Regenerative Medicine
Department of Orthopaedic Surgery
Massachusetts General Hospital
185 Cambridge Street
Boston, MA 02114
jenna_galloway@hms.harvard.edu