Research Centers

M. Amin Arnaout Laboratory

Our laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.

NEWS ARTICLES

Mass General study identifies path to safer drugs for heart disease, cancer —Massachusetts General Hospital News Articles, 23 March 2014

Solving the problem of shape shifters — Harvard Gazette, 25 March 2014

Cell Signaling: The MIDAS Touch — Nature Reviews, Molecular Cell Biology, May 2002

Role Found for Protein in Kidney Disease — Harvard FOCUS, 12 January 2001

Cell Adhesion Receptor Caught on Bended Knee — Havard FOCUS, 14 September 2001

An Anthropomorphic Integrin —Science, 12 October 2001

Integrin Binding Revealed — Nature Structural Biology, 2:181 1998

Infection Fighter Discovered — New York Times, March 26, 1993

Director, Leukocyte Biology/Inflammation and Structural Biology Programs
Principal Investigator, Harvard Stem Cell Institute
Professor of Medicine, Harvard Medical School
Chief Emeritus, Division of Nephrology

A major research goal of the Arnaout Laboratory is to elucidate the structure and function of integrins, cell adhesion receptors that play vital roles in normal physiology and disease, and use the derived information in structure-based design of new and safer anti-integrin drugs targeting heart disease, fibrosis, and cancer.

Other research interests include elucidating mechanisms underlying cyst formation in Autosomal Dominant Polycystic Kidney Disease, transcriptional regulation of hematopoiesis, mechanisms of kidney regeneration, and design of microfluidic dialysis devices.

 

 

 

 

 

 

 

 

Principal Investigator

M. Amin Arnaout, MD
Professor of Medicine, Harvard Medical School
Director, Leukocyte Biology and Inflammation Program
Director, Structural Biology Program

Chief Emeritus, Division of Nephrology
Department of Medicine
Massachusetts General Hospital
Department of Developmental and Regenerative Biology
Harvard Medical School
Principal Investigator, Harvard Stem Cell Institute

Faculty

  • Brian D. Adair, PhD
  • José Luis Alonso, PhD
  • Xiangen Li, MD, PhD
  • Jian-Ping Xiong, PhD
  • Jiaojiao Zhang, PhD 

Current Postdoctoral Fellows

  • Johannes Van Agthoven, PhD
  • Troy Camarata, PhD
  • Wassim ElJouni, PhD
  • Bhuvaneshwari Mahalingam, PhD
  • Mujib Rhaman, PhD
  • Xianliang Rui, PhD
  • Xingzhi Li, MD

Students

  • Mahmoud Alhaj, MS

Laboratory Manager

  • Zhiping Ding, PhD

  • Atomic structure of the integrin aVb3 in complex with macromolecular ligands
  • Structure-based design of novel anti-integrin therapeutics
  • EM structure of the leukocyte integrin CD11b/CD18 (aMb2)
  • Role of adaptor proteins in regulation of leukocyte integrins
  • Role of integrins in ischemia-reperfusion injury models
  • Mechanisms of cyst formation in Autosomal Dominant Polycystic Kidney Disease
  • Mechanisms of renal injury and regeneration
  • Development of microfluidic devices for dialysis
  • Transcriptional regulation of hematopoiesis

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to: aarnaout1@mgh.harvard.edu

M. Amin Arnaout Laboratory

CNY 149-8
149 13th Street
Charlestown, MA 02129

Phone: 617-726-5663
Fax: 617-726-5671
Email: aarnaout1@mgh.harvard.edu
Hours: Mon-Fri 8:00am-6pm

Public Transportation Access: yes
Disabled Access: yes

Grants Manager: Anu Jayaswal
Phone: 617-726-5667
E-mail: AJAYASWAL@MGH.HARVARD.EDU

Laboratory Manager: Zhiping Ding
Phone: 617-724-9875
E-mail: ZDING@PARTNERS.ORG