Research Centers

Arnaout Laboratory

A primary research goal of the Arnaout Laboratory is to elucidate the structure and function of integrins, cell adhesion receptors that play vital roles in normal physiology and disease. Other research interests include regulation of the diameter of blood vessels and renal tubules, fate determination in hemangioblasts, precursors of the vascular and blood cell compartments, microfluidic devices for dialysis and structure-based drug design.

Director, Leukocyte Biology/Inflammation and Structural Biology Programs
Principal Investigator, Harvard Stem Cell Institute
Professor of Medicine, Harvard Medical School

A major research focus of the Arnaout Laboratory is dissecting the role of integrins in health and disease. Integrins play pivotal roles in mediating homing of leukocytes and platelets to sites of injury, thus fending off pathogens and maintaining hemostasis, respectively. Integrins are normally expressed on the cell surface in an inactive conformation, but rapidly switch into the active ligand-binding state by agonists. Ligands bind activated integrins eliciting classic outside-in signals that regulate every aspect of cell function. Improper activation of integrins is associated with common diseases including atherosclerosis, thrombosis, diabetes, and cancer. Using genetic, molecular and structural biology approaches, our goal is to define the structural basis of affinity regulation in integrins, elucidate the intracellular pathways that regulate these receptors and that mediate their downstream effects, and use this information in designing structure-based novel therapeutics to treat common diseases linked to integrin dysfunction.

View Dr. Arnaout's Harvard Stem Cell Institute Profile
Developmental and Regenerative Biology (DRB) Graduate Program

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Principal Investigator:

  • M. Amin Arnaout, MD

Junior Faculty:

  • Brian D Adair, PhD
  • José Luis Alonso, PhD
  • Xiangen Li, MD, PhD
  • Jian-Ping Xiong, PhD

Postdoctoral Fellows:

  • Jan Van Agthoven, PhD
  • Saurabh Anand, PhD
  • Troy Camarata, PhD
  • Mujib Rahman, PhD
  • Xiangen Rui, PhD
  • Jiaojiao Zhang, PhD
  • Mike Zhang, PhD

Students:

  • Mahmoud Alhaj, MS

Technicians:

  • Zhiping Ding, MS

  • Atomic structure of the proangiogenic integrin aVb3
  • EM structure of the leukocyte integrin CD11b/CD18 (aMb2)
  • Role of adaptor proteins in regulation of leukocyte integrins
  • Role of integrins in ischemia-reperfusion injury models
  • Structure-based design of novel integrin antagonists
  • Mechanisms of cyst formation in Autosomal Dominant Polycystic Kidney Disease.
  • Mechanisms of renal injury and regeneration.
  • Development of microfluidic devices for dialysis.
  • Transcriptional regulation of erythropoiesis.

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to: arnaout@receptor.mgh.harvard.edu.

View a list of publications from this investigator:

www.ncbi.nlm.nih.gov/pubmed?cmd=search&db=pubmed&term=Arnaout+MA[au]

Arnaout Laboratory

CNY 149-8
149 13th Street
Charlestown, MA 02129

Phone: 617-726-5663
Fax: 617-726-5671
Email: arnaout@receptor.mgh.harvard.edu
Hours: Mon-Fri 8:00am-6pm

Public Transportation Access: yes
Disabled Access: yes

Executive Assistant – Kathleen Williams
Phone: 617-726-5662
E-mail: KWILLIAMS25@PARTNERS.ORG

Laboratory Manager - Zhiping Ding
Phone: 617-724-9875
E-mail: ZDING@PARTNERS.ORG