Arnaout Laboratory

The M. Amin Arnaout laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.

Overview

  • Director, Leukocyte Biology/Inflammation and Structural Biology Programs
    Principal Investigator, Harvard Stem Cell Institute
  • Professor of Medicine, Harvard Medical School
  • Chief Emeritus, Division of Nephrology

A major research goal of the Arnaout Laboratory is to elucidate the structure and function of integrins, cell adhesion receptors that play vital roles in normal physiology and disease, and use the derived information in structure-based design of new and safer anti-integrin drugs targeting heart disease, fibrosis, and cancer.

Other research interests include elucidating mechanisms underlying cyst formation in Autosomal Dominant Polycystic Kidney Disease, transcriptional regulation of hematopoiesis, mechanisms of kidney regeneration, and design of microfluidic dialysis devices.

Group Members

Faculty

  • Brian D. Adair, PhD
  • José Luis Alonso, PhD
  • Jian-Ping Xiong, PhD
  • Johannes Van Agthoven, PhD
  • Wassim ElJouni, PhD

Current Postdoctoral Fellows

  • Rachi Akiki, MD
  • Dana N. Ashoor, PhD
  • Troy Camarata, PhD
  • Bhuvaneshwari Mahalingam, PhD
  • Xingzhi Li, MD, PhD

Students

  • Michael Charara, MS

Laboratory Manager

  • Zhiping Ding, PhD

Research Projects

  • Atomic structure of the integrin aVb3 in complex with macromolecular ligands
  • Structure-based design of novel anti-integrin therapeutics
  • EM structure of the leukocyte integrin CD11b/CD18 (aMb2)
  • Role of adaptor proteins in regulation of leukocyte integrins
  • Role of integrins in ischemia-reperfusion injury models
  • Mechanisms of cyst formation in Autosomal Dominant Polycystic Kidney Disease
  • Mechanisms of renal injury and regeneration
  • Development of microfluidic devices for dialysis
  • Transcriptional regulation of hematopoiesis

Research Positions

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral) to: aarnaout1@mgh.harvard.edu

Publications

Contact

Contact Us

M. Amin Arnaout Laboratory

CNY 149-8

149 13th Street Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-726-5663
  • Fax: 617-726-5671
  • Email Us

Hours

  • Monday-Friday, 8:00 am-6:00 pm

Grants Manager: Anu Jayaswal
Phone: 617-726-5667
E-mail:AJAYASWAL@MGH.HARVARD.EDU

Laboratory Manager: Zhiping Ding
Phone: 617-724-9875
E-mail:ZDING@PARTNERS.ORG

Back to Top