SCIENCE Perspective: An Anthropomorphic Integrin
Nature Reviews: The MIDAS Touch
Chief, Division of Nephrology
Director, Leukocyte Biology/Inflammation and Structural Biology Programs
Principal Investigator, Harvard Stem Cell Institute
Professor of Medicine, Harvard Medical School
A major research focus of the Arnaout Laboratory is dissecting the role of integrins in health and disease. Integrins play pivotal roles in mediating homing of leukocytes and platelets to sites of injury, thus fending off pathogens and maintaining hemostasis, respectively. Integrins are normally expressed on the cell surface in an inactive conformation, but rapidly switch into the active ligand-binding state by agonists. Ligands bind activated integrins eliciting classic outside-in signals that regulate every aspect of cell function. Improper activation of integrins is associated with common diseases including atherosclerosis, thrombosis, diabetes, and cancer. Using genetic, molecular and structural biology approaches, our goal is to define the structural basis of affinity regulation in integrins, elucidate the intracellular pathways that regulate these receptors and that mediate their downstream effects, and use this information in designing structure-based novel therapeutics to treat common diseases linked to integrin dysfunction.
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Executive Assistant – Kathleen Williams
Laboratory Manager - Zhiping Ding
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