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Research at Mass General
Our research program focuses on the connections between mental health, behavior, and medical health in patients with heart disease and other chronic conditions.
We are interested in the impact of mood and anxiety disorders on cardiac health, and how different treatments for these disorders may impact quality of life and function. Depression and anxiety have been identified as risk factors for poor cardiac outcomes and death, independent of traditional cardiac risk factors such as high blood pressure, smoking or diabetes.
Unfortunately, depression and anxiety go unrecognized and untreated in the vast majority of patients with heart disease, despite the existence of safe and effective treatment. We have performed two randomized trials of care management for cardiac patients who have depression or anxiety disorders to determine whether having a care manager helps these patients to have better outcomes and better quality of life, and have examined the impact of psychiatric medications on cardiac health.
Also, we are increasingly interested in the role of positive thoughts and emotions in health. There is some suggestion that positive psychological states, like optimism, positive affect and self-efficacy in persons may independently predict superior health, yet these connections have not been closely studied in patients who have chronic or acute illnesses, like an acute coronary syndrome or type 2 diabetes.
Also, we have adapted positive psychological exercises to this population to determine if such exercises can boost optimism, positive affect, and self-efficacy in persons with heart disease or type 2 diabetes. We are performing ongoing studies to better develop these exercises and to determine whether they may affect biology, health behaviors, and key cardiac outcomes. We are also working to adapt these positive psychological interventions to patients with diabetes and other medical illnesses.
Finally, we are exploring the use of positive psychological interventions for patients with serious mood disorders or recent suicide attempts, to determine whether cultivating positive states provides benefit in these populations as well. Optimism and other positive states have been linked to lower rates of suicidal thoughts and suicide attempts, and an approach that focuses on this aspect of mental health may be a novel and powerful approach.
Click on the tabs to learn more about our team, our projects, and our publications.
Jeff Huffman, MD, is the Director of the Cardiac Psychiatry Research Program (CPRP), Director of Inpatient Psychiatry Research, and an Associate Professor of Psychiatry at Harvard Medical School. He currently serves as principal investigator for over ten projects, and has been awarded grants from the American Heart Association, the Templeton Foundation, American Foundation for Suicide Prevention, and the National Institutes of Health (National Heart, Lung and Blood Institute; National Institute of Diabetes and Digestive Kidney Diseases). He has over 110 peer-reviewed publications, including 95 first or senior author publications, and has mentored post doctoral psychology fellows, junior psychiatrist and psychologist faculty, medical students, psychiatry residents, research fellows, psychologists, social workers, and junior psychiatrist faculty. His areas of interest include the impact of psychiatric illness on patients with cardiac disease, and the development and use of positive psychological interventions in a wide range of populations.
Christopher Celano, MD, is an attending psychiatrist at Mass General and an Instructor in Psychiatry at Harvard Medical School and has worked on CPRP projects since 2010. He is the recipient of a K23 career development award sponsored by the National Heart, Lung, and Blood Institute to develop a psychological intervention to improve health behaviors patients with heart failure. He has published over 25 articles with the team and is an active co-investigator on several projects. His areas of interest include the impact of depression and anxiety on cardiac health as well as the promotion of positive psychological states in patients with mental illness and cardiovascular disease.
Scott Beach, MD, is a faculty psychiatrist at Mass General and an Instructor in Psychiatry at Harvard Medical School. He has been awarded the Livingston and Dupont-Warren Fellowships by Harvard Medical School for his project examining galvanic skin response in heart failure patients with and without depression. He is an active co-investigator on multiple projects and has had ten articles published, in press, or submitted in the past 12 months. Dr. Beach’s areas of expertise include QTc prolongation with psychotropic medications, the physiologic effects of depression in patients with heart disease, and catatonia.
James Januzzi, MD, is an Associate Professor of Medicine in the Division of Cardiology at Harvard Medical School, and the Director of the Cardiac Intensive Care Unit at Massachusetts General Hospital. He is a well-established researcher at Mass General with over 300 peer-reviewed research publications, over 100 review articles and chapters, and has edited three text books. He is internationally known as an expert in the study of biomarkers in patients with heart failure and other cardiac illnesses, and has served as a section editor on the recent American College of Cardiology/American Heart Association clinical practice guidelines for heart failure, and was the lead for the heart failure section for the Universal Definition of Myocardial Infarction Global Task Force. He has served as the primary cardiologist on projects for the CPRP for the past nine years, including collaborative care depression and anxiety management trials in hospitalized cardiac patients, and studies of positive psychological states in persons with heart disease.
Federico Gomez, MD, graduated from Universidad de los Andes in 2013 in Bogota, Colombia with a degree in Medicine and a minor in Biology. Federico is currently working as a Research Fellow at the CPRP, where he applies his expertise to participant screening and medical data collection and management. He also contributes to the presentation of study findings in publications and poster sessions. Prior to joining the CPRP, Federico conducted research concerning diabetes, cognition and memory. In the future, he intends to apply for a Psychiatry residency program.
Carol Mastromauro, MSW, LICSW, is one of the interventionists for the CPRP. She is a clinical research social worker who has been with the team for seven years. Carol specializes in anxiety and depression treatment and positive psychology interventions for cardiac populations. She has administered interventions to more than 200 subjects during her time at the CPRP, and recruited and evaluated over 350 cardiac inpatients for the SUCCEED and MOSAIC studies. Prior to joining the CPRP, Carol worked in geriatric research on memory disorders as well as working with Huntington’s disease patients and their families.
Rachel Millstein, PhD, MHS, is a clinical and research post-doctoral psychology fellow in her third year with the CPRP. She graduated from the SDSU/UCSD Joint Doctoral Program in Clinical Psychology, with a focus on Behavioral Medicine. She also holds an MHS in Epidemiology from the Johns Hopkins Bloomberg School of Public Health and a BA in Psychology from Wellesley College. Rachel is a primary interventionist for the PEACE trial and project director for BEHOLD. She is also the recipient of a K23 career development award sponsored by the National Institutes of Health to develop a multilevel intervention to promote physical activity among patients with metabolic syndrome. Her research interests focus on chronic disease and obesity prevention, specifically multi-level nutrition and physical activity interventions, having authored or co-authored many peer-reviewed articles and book chapters in these fields. Her clinical interests include evidence-based therapies, positive psychology, and mindfulness techniques for improving mood, anxiety, and well-being.
Christina DuBois, BA, graduated from Skidmore College in 2011 summa cum laude with a degree in psychology. She serves as the lead research coordinator for the CPRP and is in her third year with the program. She has delivered positive psychology interventions, performed qualitative interviews, and coordinated several of the team’s projects. Currently, she is the interventionist for a collaborative positive psychology project with the Diabetes Outpatient Center. Previously, Tina interned at a hospice, a group home for runaway youth, and a domestic violence center as a financial resource coordinator. She is currently pursuing her MSW at the Boston University School of Social Work.
Eleanor Beale, BA, graduated from Skidmore College in 2012 summa cum laude with a degree in psychology. In her fifth year with the program, she is the lead research coordinator for the REACH study, developing a positive psychology intervention to promote health behaviors in Heart Failure patients, and runs eight of the other studies at the CPRP. She is also the primary coordinator for the ongoing project (PI:Nock) working to utilize a multimodal assessment approach to suicide risk. Previously, Ellie developed functional behavioral assessments for a day program for individuals with developmental disabilities, and interned at a substance abuse center. Currently, Ellie is applying to Clinical Psychology PhD programs to start in Fall 2017.
Kirsti Campbell, BS, graduated from the University of Virginia in 2012 with a degree in biology with highest distinction. She is currently a fourth year MD candidate in the New Pathway program at Harvard Medical School (HMS), and she completed her Principal Clinical Experience at Mass General during the 2014-2015 academic year. With funding through the CPRP and HMS, Kirsti will work as an interventionist for the PEACE study and is conducting a study of patient factors associated with engagement in positive psychological interventions.
Sean Legler is a fourth-year MD candidate at Harvard Medical School. He is conducting pilot studies in motivational messaging, works as an interventionist for the PEACE study, and is examining the relationship between gratitude and recovery from acute coronary events. Prior to joining the CPRP, he has done research in the neuroscience of addiction, social psychology, and stem cell transplantation. He has also worked in electronic health records technology both in the US and with Partners in Health in Haiti. He has served as a member of the Harvard Center for Primary Care Student Leadership Council, an intern at the Institute for Clinical Systems Improvement, and was selected as a Mayo Innovation Scholar.
Ariana Albanese, BA, graduated from Harvard College in 2015 magna cum laude with a degree in history and literature and a secondary degree in psychology. She is in her second year with the program and primarily manages the NIH-funded PEACE study, which is currently in its third stage. In this role she performs a variety of tasks ranging from subject recruitment to data organization. Ari also previously worked as a project coordinator in Dr. John Weisz’s Laboratory for Youth Mental Health at Harvard University, participating in research projects which focus on youth internalizing disorders and emotion regulation.
Taylor Gianangelo, BA, graduated from the University of Pennsylvania in 2016 summa cum laude with a degree in biology. Currently in her first year with the program, she is serving as the primary research coordinator for the BEHOLD study. In this role, she is responsible for recruiting and enrolling diabetes patients as well as for organizing and managing study-related data. Before joining the CPRP, Taylor was a research assistant at Penn’s Computational Memory Lab, and was involved in the study of human memory using EEG technology. She has also conducted clinical research at the Children’s Hospital of Philadelphia and at the Hospital of the University of Pennsylvania.
Melanie Freedman, BS, graduated cum laude from Northeastern University with a degree in psychology. She is the resource specialist on the inpatient psychiatric unit, and part-time research assistant for the CPRP, working primarily on the PEACE study. Previously, Melanie interned at an early intervention psychosis clinic at Beth Israel Deaconess Medical Center, and worked as a research assistant at the Lifespan Emotional Development Lab at Northeastern University, which investigated emotion regulation and attention throughout the lifespan.
Brian Healy, PhD, is an Assistant Professor in the Department of Neurology at Harvard Medical School, a member of the Biostatistics Center at Massachusetts General Hospital, and an Instructor in Biostatistics at the Harvard School of Public Health. Dr. Healy is also the lead biostatistician for the Partners Multiple Sclerosis Center, which is affiliated with Brigham and Women's Hospital. His primary research interest is statistical methods development and application for modeling of multiple sclerosis. He has been working with the CPRP for the past 5 years, and he has participated in the design and analysis of several studies.
Elizabeth Madva, MD, is a second year resident in the MGH/McLean psychiatry residency and a member of the residency's Research Concentration Program. She graduated from Weill Cornell Medical College in 2015 and from Yale University in 2008, magna cum laude, with a BA in Cognitive Science. She is a member of the AOA and Phi Beta Kappa honor societies. She began working with the CPRP in 2016 to further explore her interest in the relationship between psychiatry and other medical fields. Her other clinical and research interests include somatic symptom disorders, cognitive development, and unconscious and implicit influences on behavior.
Hermioni Lokko, MD, MPP, is a clinical fellow in psycho-oncology at the Brigham and Women’s Hospital/Dana Farber Cancer Institute. She completed her adult psychiatry residency training at the Massachusetts General Hospital and McLean Hospital where she also served as Administrative Chief Resident. She completed her MD and MPP at the Harvard Medical School and Harvard Kennedy School of Government respectively. Her clinical interests entail managing psychiatric comorbidities in cancer patients. Her non-clinical interests include undergraduate and graduate medical education as well as the impact of psychiatric illness, management strategies and palliative care in diverse cancer patients for the entire care cycle. At the CPRP, she has been helping with recruitment for the PEACE trail.
Dr. Elyse Park (qualitative research and motivational interviewing): Mongan Institute for Health Policy
Dr. Andrés Bedoya (behavioral interventions)
Dr. Hanna Gaggin (cardiology)
Bettina Hoeppner (technology use for behavior change), The Benson-Henry Institute for Mind-Body Medicine, Massachusetts General Hospital
Dr. Matthew Nock, (prediction and prevention of suicide/self-harm), Department of Psychology, Harvard University
Dr. Linda Collins, (novel methods of optimizing and evaluating multicomponent behavioral interventions), The Methodology Center, Penn State University
Dr. Todd Kashdan, (positive psychology and interventions to increase well-being), The Center for Consciousness & Transformation, George Mason University
Dr. Julia Boehm, (positive psychology), Department of Psychology, Chapman University
Bruce Rollman (treatment of depression and anxiety in cardiac patients), University of Pittsburgh Medical Center
Dr. Steven Safren, Department of Psychology, University of Miami
Dr. Evan Kleiman, (identifying risk and resilience factors for suicide,) Department of Psychology, Harvard University
Dr. Laura Kubzansky and the Lee Kum Shueng Health and Happiness Center
Medical Students:Gillian SowdenChris DoughtyChristina Carr
Residents:Curtis WittmannAmy TaylorLeah BauerKeri OxleyMichael Soule
Faculty/Fellows:Felicia SmithAndres CaroTrina ChangGiselle Perez-LougeeOriana Vesga-LopezLaura SuarezAna Claudia Villegas
Research Coordinators:Marguerite BeiserRita SeabrookShannon MooreEmma Lenihan
Social Work and Nursing Interventionists:Rachel RodmanStephanie MahnksMeaghan Morrison
Special thanks: Our work has also been generously supported by the esteemed Avery D. Weisman, MD, of the eponymous Massachusetts General Hospital Psychiatry Consultation Service and a long-standing national leader in psychosomatic medicine. His support has allowed the CPRP to continue to investigate the associations between positive and negative emotional states and physical health and well-being, and we are forever indebted.
Developing a positive psychology intervention to improve cardiac health behaviorsNational Institutes of Health: National Heart Lung and Blood Institute (1R01HL113272-01A1)This project aims to systematically develop a positive psychological intervention for patients with a recent acute coronary syndrome to determine if such an intervention leads to greater participation in health behaviors (e.g., better diet, more physical activity) in the weeks and months following the acute cardiac event.
Principal Investigator (PI): Jeff Huffman
A psychological-behavioral intervention for physical activity in type 2 diabetesNational Institute of Diabetes and Digestive and Kidney Diseases, R21DK109313This is a randomized pilot trial of a intervention (planned N=60) combining positive psychological and goal-setting programs to improve physical activity in people with type 2 diabetes. Outcome measures include assessments of feasibility, acceptability and physical activity.
Developing a positive psychology intervention to improve health behaviors in patients with heart failureThe National Heart, Lung, and Blood Institute (K23 2015P000069)This project aims to methodically create a positive psychological intervention for patients with heart failure to examine if this type of intervention leads to improvement in health behaviors such as diet and physical activity.
Principal Investigator (PI): Christopher Celano
President and Fellows of Harvard College AwardThis project extends the work of the GRACE study (below) by examining connections between optimism/gratitude, health behaviors, and cardiac events in post-acute coronary syndrome patients over a three-year period.
Qualitative research on positive emotions to improve health behavior adherence in DM Type II patients This project aims to gather qualitative information about positive emotions (e.g., optimism, gratitude) and health behavior adherence (e.g., better diet, more physical activity) in patients with Type 2 Diabetes, to aid in development of a positive psychology intervention for this population.
Principal Investigator (PI): Jeff Huffman.
American Diabetes AssociationThis is a 16-week study of a phone-based combined Positive Psychology-Motivational Interviewing intervention aimed to improve physical activity in patients who have type 2 diabetes and are suboptimally physically active. It will involve two parts: 1) a single-arm trial to assess feasibility and 2) a larger 16 week trial in which it is tested against an attentional control condition.
National Institute of HealthThe goal of this project is to identify insufficiently active primary care patients with metabolic syndrome and help them increase their physical activity by creating a multilevel intervention addressing targets at the individual, social, and environmental levels. This project will develop and test a combined positive psychology and motivational interviewing intervention in a group setting and have participants complete a neighborhood walkability assessment.
Principal Investigator (PI): Rachel Millstein
Anonymous donor fundingThis is a project to pilot test a multidisciplinary care management program to optimize diagnosis and management of persons with persistent chest pain despite a negative cardiac assessment.
Principal Investigators (PIs): Jeff Huffman, Elizabeth Madva
Donor funding This project utilizes a combination of wrist-worn physiological monitors (assessing physical activity, heart rate, and electrodermal activity), frequently given brief questionnaires concerning mood and thoughts of self-injury administered on a smart phone, and software to track cellphone usage, in order to evaluate the factors which might predict thoughts of suicide during inpatient psychiatric treatment.
Principal Investigator (PI): Matthew Nock
The impact of gratitude on biology and behavior in persons with heart diseaseGreater Good Science Center/Templeton FoundationThis project prospectively studied the connections between positive psychological states (e.g., gratitude, optimism), measured two weeks after an acute coronary syndrome, and improvements in biomarkers and health behaviors at 6 months.
Development of a positive psychology intervention to reduce suicide riskAmerican Foundation for Suicide Prevention Standard Research GrantThis was an exploratory study of a 6-week positive psychological intervention (planned N=50) for patients hospitalized with major depressive disorder and who had suicidal thoughts prior to admission. Participants in the intervention arm completed a positive psychological exercise in the hospital, followed by exercises over the subsequent six weeks; participants in the control arm completed cognitive/recollection tasks. Outcome measures include assessments of suicidality/hopelessness, mood symptoms, and overall intervention feasibility. We found that the control condition was associated with significantly greater improvements in hopelessness, positive psychological constructs, as well as other suicide risk factors, indicating a need for further study of such interventions in populations at high suicide risk.
Development of a positive psychology intervention to reduce suicide risk in patients with bipolar disorderDupont-Warren and Livingston Fellowships, Harvard Medical SchoolThis was a pilot study of a 4-week positive psychological intervention (planned N=30) for patients hospitalized for bipolar disorder. Subjects in the intervention arm completed a positive psychological exercise in the hospital, followed by exercises over the subsequent four weeks; participants in the control arm completed cognitive/recollection tasks. Outcome measures included assessments of feasibility, acceptability and clinical impact.
Dupont-Warren and Livingston Fellowships, Harvard Medical SchoolThis study examined the impact of depression on autonomic nervous system function in patients hospitalized with heart failure. Matched patients with and without major depression had measurements taken of galvanic skin response and urinary catecholamines, and we hypothesized that autonomic dysfunction will be greater in depressed patients, independent of the severity of cardiac illness.
Principal Investigator (PI): Scott Beach
A collaborative care program to improve treatment of anxiety disorder in hospitalized patients with cardiac diseaseAmerican Heart Association Grant-in-AidThis was a randomized controlled trial of a care management program to manage depression and anxiety disorders among patients hospitalized for cardiac illness (N=183). A multidisciplinary collaborative care intervention, led by a social work care manager, was initiated in the hospital and continued by phone for six months after discharge. The intervention was associated with improvements in mental-health related quality of life at six months, reduced depressive symptoms, and better overall functioning. Patients randomized to the collaborative care intervention also had higher rates of treatment of a mental health disorder.
A collaborative care program to improve depression management in cardiac patientsAmerican Heart Association (0735530T)This was a randomized controlled trial (N=175) of a care management program to manage depression among patients hospitalized for cardiac illness. A multidisciplinary collaborative care intervention, led by a social work care manager, was initiated in the hospital and continued by phone for 12 weeks after discharge. The intervention was associated with improvements in depression, mental health-related quality of life, and cognitive symptoms (versus usual care) during the intervention and improved adherence and cardiac symptoms following the intervention.
Development of a positive psychology intervention to reduce suicide riskCenter for Disease Control (R01 DP000339)This was an exploratory study of nine positive psychological exercises in patients hospitalized for suicidal thoughts or a suicide attempt. Participants (N=61) were administered exercises in random order during their admission, and rated the ease of completion and impact of the exercises before and after completion. Overall, the exercises were feasible, well-accepted, and associated with short-term improvements in key symptoms in this cohort.
PI: Jeff Huffman
Mind-body interventions in cardiac patientsCenter for Disease Control (R01 DP000339)This was a three-arm pilot study examining the feasibility of three positive psychological exercises (on gratitude, optimism, and altruism) in patients hospitalized for heart failure or an acute coronary syndrome. The exercises were well-accepted, and the positive psychology exercises appeared to lead to greater improvements compared to the active (relaxation response) and attentional (recollection) control conditions.
A positive psychology program for patients with type 2 diabetes: Pilot studyThis was a pilot study of a 10-week positive psychological intervention (N=15) for outpatients who have type 2 diabetes and poor adherence to one or more diabetes-related health behaviors. Participants completed seven exercises over the course of 10 weeks. Outcome measures included assessments of feasibility, acceptability, and clinical impact of the intervention. The intervention was found by participants to be both feasible and acceptable.
Celano CM, Beale EE, Mastromauro CA, Stewart JG, Millstein RA, Auerbach RP, Bedoya CA, Huffman JC. Psychological interventions to reduce suicidality in high-risk patients with major depression: a randomized controlled trial. Psychol Med 2016, in press.
Campbell KA, Madva E, Villegas AC, Beale EE, Beach SR, Wasfy J, Albanese AM, Huffman JC. Non-cardiac chest pain: a review for the consultation-liaison psychiatrist. Psychosomatics 2016, in press.
Celano CM, Beale EE, Beach SR, Belcher AM, Suarez L, Motiwala SR, Gandhi PU, Gaggin H, Januzzi JL Jr, Healy BC, Huffman JC. Associations Between Psychological Constructs and Cardiac Biomarkers After Acute Coronary Syndrome. Psychosom Med. 2016 Sep 30. [Epub ahead of print].
Kubzansky LD, Kim ES, Salinas J, Huffman JC, Kawachi I. Happiness, health, and mortality. Lancet. 2016;388(10039):27.
Panagioti M, Bower P, Kontopantelis E, Lovell K, Gilbody S, Waheed W, Dickens C, Archer J, Simon G, Ell K, Huffman JC, Richards DA, van der Feltz-Cornelis C, Adler DA, Bruce M, Buszewicz M, Cole MG, Davidson KW, de Jonge P, Gensichen J, Huijbregts K, Menchetti M, Patel V, Rollman B, Shaffer J, Zijlstra-Vlasveld MC, Coventry PA. Association Between Chronic Physical Conditions and the Effectiveness of Collaborative Care for Depression: An Individual Participant Data Meta-analysis. JAMA Psychiatry. 2016;73(9):978-989.
Celano CM, Daunis DJ, Lokko HN, Campbell KA, Huffman JC. Anxiety disorders and cardiovascular disease. Curr Psychiatry Rep. 2016, Nov; 18(11):101.
Huffman JC, Albanese AM, Campbell KA, Celano CM, Millstein RA, Mastromauro CA, Healy BC, Chung WJ, Januzzi JL, Collins LM, Park ER. The Positive Emotions after Acute Coronary Events (PEACE) Behavioral Health Intervention: Design, Rationale, and Preliminary Feasibility of a Factorial Design Study. Clinical Trials. 2016, in press.
Millstein, RA, Celano, CM, Beale, EE, Beach, SR, Suarez, L, Belcher AM, Januzzi, JL, Huffman, JC. The effects of optimism and gratitude on adherence, functioning, and mental health following an acute coronary syndrome. Gen Hosp Psychiatry. 2016, 43:17-22..
Rundell JR, Huffman JC. The COMPASS initiative: implementing a complex integrated care program. Gen Hosp Psychiatry. 2016, Jul 12. pii: S0163-8343(16)30168-2.
DuBois CM, Millstein RA, Celano CM, Wexler DJ, Huffman JC. Feasibility and Acceptability of a Positive Psychological intervention for patients with type 2 diabetes. Prim Care Companion CNS Disord. 2016, May 5;18(3).
Nikrahan GR, Suarez L, Asgari K, Beach SR, Celano CM, Kalantari M, Abedi MR, Etesampour A, Abbas R, Huffman JC. Positive Psychology Interventions for Patients With Heart Disease: A Preliminary Randomized Trial. Psychosomatics. 2016;57(4):348-358.
Nikrahan GR, Laferton JA, Asgari K, Kalantari M, Abedi MR, Etesampour A, Rezaei A, Suarez L, Huffman JC. Effects of Positive Psychology Interventions on Risk Biomarkers in Coronary Patients: A Randomized, Wait-List Controlled Pilot Trial. Psychosomatics. 2016;57(4):359-368.
Soule MC, Beale EE, Suarez L, Beach SR, Mastromauro CA, Celano CM, Moore SV, Huffman JC. Understanding motivations to participate in an observational research study: Why do patients enroll? Soc Work Health Care. 2016;55(3):231-246.
Celano CM, Healy B, Suarez L, Levy DE, Mastromauro C, Januzzi JL, Huffman JC. Cost-Effectiveness of a Collaborative Care Depression and Anxiety Treatment Program in Patients with Acute Cardiac Illness. Value Health. 2016;19(2):185-191.
Huffman JC, Beale EE, Celano CM, Beach SR, Belcher AM, Moore SV, Suarez L, Motiwala SR, Gandhi PU, Gaggin HK. Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome The Gratitude Research in Acute Coronary Events Study. Circ Cardiovasc Qual Outcomes. 2016;9(1):55-63.
Huffman JC, Boehm JK, Beach SR, Beale EE, DuBois CM, Healy BC. Relationship of optimism and suicidal ideation in three groups of patients at varying levels of suicide risk. J Psychiatr Res. 2016;77:76-84.
Freudenreich O, Huffman JC, Sharpe M, Beach SR, Celano CM, Chwastiak LA, Cohen MA, Dickerman A, Fitz-Gerald MJ, Kontos N, Mittal L, Nejad SH, Niazi S, Novak M, Philbrick K, Rasimas JJ, Shim J, Simpson SA, Walker A, Walker J, Wichman CL, Zimbrean P, Sollner W, Stern TA. Updates in Psychosomatic Medicine: 2014. Psychosomatics. 2015;56(5):445-459.
Huffman JC, Celano CM. Depression in cardiovascular disease: From awareness to action. Trends Cardiovasc Med. 2015;25(7):623-624.
Beach SR, Walker J, Celano CM, Mastromauro CA, Sharpe M, Huffman JC. Implementing collaborative care programs for psychiatric disorders in medical settings: a practical guide. Gen Hosp Psychiatry. 2015;37(6):522-527.
DuBois CM, Lopez OV, Beale EE, Healy BC, Boehm JK, Huffman JC. Relationships between positive psychological constructs and health outcomes in patients with cardiovascular disease: a systematic review. Int J Cardiol. 2015;195:265-280.
Suarez L, Beach SR, Moore SV, Mastromauro CA, Januzzi JL, Celano CM, Chang TE, Huffman JC. Use of the Patient Health Questionnaire-9 and a detailed suicide evaluation in determining imminent suicidality in distressed patients with cardiac disease. Psychosomatics. 2015;56(2):181-189.
Huffman JC, Beale EE, Beach SR, Celano CM, Belcher AM, Moore SV, Suarez L, Gandhi PU, Motiwala SR, Gaggin H, Januzzi JL. Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study. Contemp Clin Trials. 2015;44:11-19.
Celano CM, Millstein RA, Bedoya CA, Healy BC, Roest AM, Huffman JC. Association between anxiety and mortality in patients with coronary artery disease: a meta-analysis. Am Heart J. 2015;170(6):1105-1115.
Huffman J, Millstein R, Mastromauro C, Moore S, Celano C, Bedoya C, Suarez L, Boehm J, Januzzi J. A Positive Psychology Intervention for Patients with an Acute Coronary Syndrome: Treatment Development and Proof-of-Concept Trial. J Happiness Stud. 2015:1-22.
Huffman JC, DuBois CM, Millstein RA, Celano CM, Wexler D. Positive psychological interventions for patients with type 2 diabetes: rationale, theoretical model, and intervention development. J Diabetes Res. 2015;2015:428349.
Huffman JC, Moore SV, DuBois CM, Mastromauro CA, Suarez L, Park ER. An exploratory mixed methods analysis of adherence predictors following acute coronary syndrome. Psychol Health Med. 2015;20(5):541-550.
Huffman JC, DuBois CM, Mastromauro CA, Moore SV, Suarez L, Park ER. Positive psychological states and health behaviors in acute coronary syndrome patients: A qualitative study. J Health Psychol. 2014 64:27-34.
Beach SR, Kostis WJ, Celano CM, Januzzi JL, Ruskin JN, Noseworthy PA, Huffman JC. Meta-analysis of selective serotonin reuptake inhibitor-associated QTc prolongation. J Clin Psychiatry. 2014;75(5):e441-449.
Huffman JC, Niazi SK, Rundell JR, Sharpe M, Katon WJ. Essential articles on collaborative care models for the treatment of psychiatric disorders in medical settings: a publication by the Academy of Psychosomatic Medicine Research and Evidence-Based Practice Committee. Psychosomatics. 2014;55(2):109-122.
Huffman JC, Mastromauro CA, Beach SR, Celano CM, DuBois CM, Healy BC, Suarez L, Rollman BL, Januzzi JL. Collaborative care for depression and anxiety disorders in patients with recent cardiac events: the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized clinical trial. JAMA Intern Med. 2014;174(6):927-935.
Huffman JC, DuBois CM, Healy BC, Boehm JK, Kashdan TB, Celano CM, Denninger JW, Lyubomirsky S. Feasibility and utility of positive psychology exercises for suicidal inpatients. Gen Hosp Psychiatry. 2014;36(1):88-94.
Denninger JW, Bhasin M, Huffman J, Niles H, Creager M, Pande R, Liberman T, Fricchione G, Benson H, Zusman R. Clinical and genomic effects of a relaxation response-based mind-body intervention in stage I hypertension. The Journal of Alternative and Complementary Medicine. 2014;20(5):A54-A54.
Rollman BL, Huffman JC. Treating anxiety in the presence of medical comorbidity: calmly moving forward. Psychosom Med. 2013;75(8):710-712.
Beach SR, Januzzi JL, Mastromauro CA, Healy BC, Beale EE, Celano CM, Huffman JC. Patient Health Questionnaire-9 score and adverse cardiac outcomes in patients hospitalized for acute cardiac disease. J Psychosom Res. 2013;75(5):409-413.
Huffman JC. Review: depression after myocardial infarction is associated with increased risk of all-cause mortality and cardiovascular events. J Psychosom Res. 2013;16(4):110.
Huffman JC, Beach SR, Suarez L, Mastromauro CA, Dubois CM, Celano CM, Rollman BL, Januzzi JL. Design and baseline data from the Management of Sadness and Anxiety in Cardiology (MOSAIC) randomized controlled trial. Contemp Clin Trials. 2013;36(2):488-501.
Celano CM, Suarez L, Mastromauro C, Januzzi JL, Huffman JC. Feasibility and utility of screening for depression and anxiety disorders in patients with cardiovascular disease. Circ Cardiovasc Qual Outcomes. 2013;6(4):498-504.
Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC. QTc prolongation, torsades de pointes, and psychotropic medications. Psychosomatics. 2013;54(1):1-13.
Sowden GL, Mastromauro CA, Seabrook RC, Celano CM, Rollman BL, Huffman JC. Baseline physical health-related quality of life and subsequent depression outcomes in cardiac patients. Psychiatry Res. 2013;208(3):288-290.
Celano CM, Beale EE, Moore SV, Wexler DJ, Huffman JC. Positive psychological characteristics in diabetes: a review. Curr Diab Rep. 2013;13:917-929.
Huffman JC, Celano CM, Beach SR, Motiwala SR, Januzzi JL. Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. Cardiovasc Psychiatry Neurol. 2013;2013:695925.
Bauer LK, Caro MA, Beach SR, Mastromauro CA, Lenihan E, Januzzi JL, Huffman JC. Effects of depression and anxiety improvement on adherence to medication and health behaviors in recently hospitalized cardiac patients. Am J Cardiol. 2012;109(9):1266-1271.
DuBois CM, Beach SR, Kashdan TB, Nyer MB, Park ER, Celano CM, Huffman JC. Positive psychological attributes and cardiac outcomes: associations, mechanisms, and interventions. Psychosomatics. 2012;53(4):303-318.
Caro MA, Sowden GL, Mastromauro CA, Mahnks S, Beach SR, Januzzi JL, Huffman JC. Risk factors for positive depression screens in hospitalized cardiac patients. J Cardiol. 2012;60(1):72-77.
Wexler DJ, Porneala B, Chang Y, Huang ES, Huffman JC, Grant RW. Diabetes differentially affects depression and self-rated health by age in the U.S. Diabetes Care. 2012;35(7):1575-1577.
Celano CM, Mastromauro CA, Lenihan EC, Januzzi JL, Rollman BL, Huffman JC. Association of baseline anxiety with depression persistence at 6 months in patients with acute cardiac illness. Psychosom Med. 2012;74(1):93-99.
Celano CM, Huffman JC. Depression and cardiac disease: a review. Cardiol Rev. 2011;19(3):130-142.
Huffman JC, Mastromauro CA, Sowden G, Fricchione GL, Healy BC, Januzzi JL. Impact of a depression care management program for hospitalized cardiac patients. Circ Cardiovasc Qual Outcomes. 2011;4(2):198-205.
Huffman JC, Mastromauro CA, Sowden GL, Wittmann C, Rodman R, Januzzi JL. A collaborative care depression management program for cardiac inpatients: depression characteristics and in-hospital outcomes. Psychosomatics. 2011;52(1):26-33.
Huffman JC, Mastromauro CA, Boehm JK, Seabrook R, Fricchione GL, Denninger JW, Lyubomirsky S. Development of a positive psychology intervention for patients with acute cardiovascular disease. Heart Int. 2011;6(2):e14.
Bauer LK, Huffman JC. Is low cholesterol associated with depression in cardiac patients? Int J Cardiol. 2010;145(3):537-539.
Sowden G, Mastromauro CA, Januzzi JL, Fricchione GL, Huffman JC. Detection of depression in cardiac inpatients: feasibility and results of systematic screening. Am Heart J. 2010;159(5):780-787.
Huffman JC, Celano CM, Januzzi JL. The relationship between depression, anxiety, and cardiovascular outcomes in patients with acute coronary syndromes. Neuropsychiatr Dis Treat. 2010;6:123-136.
Huffman JC, Doughty CT, Januzzi JL, Pirl WF, Smith FA, Fricchione GL. Screening for major depression in post-myocardial infarction patients: operating characteristics of the Beck Depression Inventory-II. Int J Psychiatry Med. 2010;40(2):187-197.
Huffman JC, Smith FA, Fricchione GL, Januzzi JL, Nadelman S, Pirl WF. Depression and failure of cholesterol lowering after acute myocardial infarction. Prim Care Companion J Clin Psychiatry. 2010;12(1):PCC.08m00766.
Huffman JC. Could being happy give you a healthy heart? Future Cardiol. 2009;5(4):325-327.
Sowden GL, Huffman JC. The impact of mental illness on cardiac outcomes: a review for the cardiologist. Int J Cardiol. 2009;132(1):30-37.
Huffman JC, Smith FA, Blais MA, Taylor AM, Januzzi JL, Fricchione GL. Pre-existing major depression predicts in-hospital cardiac complications after acute myocardial infarction. Psychosomatics. 2008;49(4):309-316.
Huffman JC, Smith FA, Blais MA, Januzzi JL, Fricchione GL. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res. 2008;65(6):557-563.
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