Research Centers

Gomperts Lab

The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease

Dr. Gomperts' basic science interests focus on understanding how dopamine cells and cells of the hippocampus communicate with one another and with their target regions to guide behaviors.

Dr. Gomperts' clinical interests are cognitive impairment and dementias, such as dementia with Lewy bodies and Alzheimer's disease, as well as movement disorders such as Parkinson's disease. His clinical research interests include the development of blood and imaging biomakers for cognitive impairment in dementia with Lewy bodies and Parkinson's disease.


Principal Investigator

Stephen N. Gomperts, MD, PhD

  • Instructor in Neurology 
    Harvard Medical School
  • Assistant in Neurology,
    Massachusetts General Hospital



Lab Members

  • Kevin Neville, PhD
  • Daniel Graziano, Tech II

Could brain amyloid deposition be a factor in early onset dementia in patients with dementia with Lewy bodies (DLB)?

In this clinical study we sought to confirm the hypothesis that brain amyloid deposition, an early feature of Dementia with Lewy Bodies, may account, in part, for its early dementia.We also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases. Many patients with Parkinson's disease develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies; PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism.

Request a list of currently open positions at

Read about and apply for residency, fellowship and observership programs at

Apply for temporary positions (summer interns)through the Bulfinch Temporary Service Web site at Search for all opportunities using ID# 2200484.

All applicants should register with the Mass General Careers Web site at

View all publications on Pubmed

  1. Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia.
    Gomperts SN, Locascio JJ, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH.
    Neurology. 2013 Jan 1;80(1):85-91. doi: 10.1212/WNL.0b013e31827b1a07. Epub 2012 Dec 12.
    PMID: 23243071 [PubMed - indexed for MEDLINE]
  2. Brain amyloid and cognition in Lewy body diseases.
    Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH.
    Mov Disord. 2012 Jul;27(8):965-73. doi: 10.1002/mds.25048. Epub 2012 Jun 12.
    PMID: 22693110 [PubMed - indexed for MEDLINE] Free PMC Article
  3. Micro-drive array for chronic in vivo recording: tetrode assembly.
    Nguyen DP, Layton SP, Hale G, Gomperts SN, Davidson TJ, Kloosterman F, Wilson MA.
    J Vis Exp. 2009 Apr 22;(26). doi:pii: 1098. 10.3791/1098.
    PMID: 19387422 [PubMed - indexed for MEDLINE] Free PMC Article
    Related citations

MassGeneral Institute for Neurodegenerative Disease

Building 114, Charlestown Navy Yard
Mailcode: CNY B114-2-2003
114 16th Street, Room 2003
Charlestown, MA 02129

Phone: 617-726-2000
Fax: 617-724-1480

Public Transportation Access: yes
Disabled Access: yes

How to Apply for Positions

How to apply for jobs: Send an e-mail to to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Shawn Fitzgibbons in the Mass General Development office at 617-643-0447 or


Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

Directions to MIND Research labs (PDF)

Clinical Appointments, Consultations & Clinical Trials

Please visit the main Neurology Service Contact page for all other contact information.