Stem Cell Therapeutics and Imaging Program

Stem Cell Therapeutics and Imaging Program

The Stem Cell Therapeutics and Imaging Program focuses on engineering therapeutic and diagnostic stem cells for different pathologies in pre-clinical settings and translating them into clinics.

Overview

The long-term goals of the Stem Cell Therapeutics and Imaging Program are the engineering of therapeutic and diagnostic stem cells utilizing our recently developed bi-functional novel therapeutic and biological imaging agents for therapeutics and imaging of molecular events in pre-clinical and clinical settings.

Led by Program Director Khalid Shah, MS, PhD, the research team is comprised of passionate interdisciplinary scientists who specialize in areas of stem cell biology, molecular biology, genetic engineering, whole body and single cell imaging, experimental animal models and pharmacology/ toxicology, all of which are key to the successful operation of a multidisciplinary program.

 

Lab Members

Name

Position

Hiroaki Wakimoto

Assistant Professor

Yanni Zhu

Postdoctoral Fellow

Wanlu Du

Postdoctoral Fellow

Sung Hugh Choi

Postdoctoral Fellow

Clemens Reinshagen

Postdoctoral Fellow

Jasneet Khalsa

Postdoctoral Fellow

Deepak Bhere

Research Associate

Pim Van de Donk

Intern

Kerstin Voelkl

Intern

Stefan Hutten

Intern

Oumima Bouguzzoal

Intern

Priyanka Ravikumar

Intern

Kennedy Geenen

Intern

GiHun Choi

Intern

Rajet Vatsa

Intern

Nabeel Nissar

Intern

Amina Kunnumal

Intern

JungMin Suh

Intern

Eloi Le Roux

Intern

Anusha Venugopalan

HR Admin

Latest Publications

  1. Zhu, Y., Choi, S.H. and Shah, K. Receptor targeted antibodies for cancer therapy. Lancet Oncology. 2015; Nov;16(15):e543-54. doi: 10.1016/S1470-2045(15)00039-X.
  2. Bagci-Onder, T., Du, W., Figueiredo, Martinez-Quintanilla, J., and Shah, K. Targeting breast to brain metastatic tumors with death receptor ligand expressing therapeutic stem cells. BRAIN Doi:10.1093/brain/awv094
  3. Bhere, D.,Shah, K. Stem Cell-Based Therapies for Cancer. Cancer Res. 2015;127:159-89. doi: 10.1016/bs .acr.2015.04.012. Epub 2015 May 19.
  4. Wehrenberg-Klee, E., Redjal, N., Leece, A., Turker, N.S., Heidari, P.,Shah, K., Mahmood U.PET imaging of glioblastoma multiforme EGFR expression for therapeutic decision guidance.Am J Nucl Med Mol Imaging. 2015 Jun 15;5(4):379-89.
  5. Choi, SH., Tamura, K., Khajuria, R., Lawler, J., and Shah, K. Antiangiogenic variant of TSP-1 targets TRAIL resistance in brain tumors. Molecular Therapy. 2015, 23(2):235-43. doi: 10.1038/mt.2014.214.
  6. Redjal, N., Zhu, Y. and Shah, K. Targeting TRAIL resistance in GBMs: Combining systemically delivered chemotherapy with encapsulated stem cell TRAIL. Stem Cells. 33(1):101-10. doi: 10.1002/stem.1834.
  7. Martinez-Quintanilla, J., He, D., Wakimoto, H, Alemany, R and Shah, K. Encapsulated stem cells loaded with hyaluronidase expressing oncolytic virus for GBM therapy. Therapy 2015. 23(1):108-18. doi: 10.1038/mt.2014.204.
  8. Stuckey, D and Shah, K. Therapeutic stem cells for cancer. Nature Reviews Cancer. 2014 Sep 1. doi: 10.1038/nrc3798. [Epub ahead of print]
  9. Stuckey, D., Hingtgen, S.D., Rich, B., Nesterenko, I., and Shah, K. Engineering toxin-resistant therapeutic stem cells to treat GBM. Stem Cells. Oct 24. doi: 10.1002/stem.1874. [Epub ahead of print]
  10. Sullivan, J.P., Nahed, B.V., Madden, M.W., Oliveira, S.M., Springer, S., Bhere, D., Chi, A.S., Wakimoto, H., Kapur,R., Shah, K., Iafrate, J.A.,, Curry, W.T., Loeffler, J.S., Batchelor, T.T., Louis, D.N., Toner, M., Maheswaran, S. and Haber, D.A. Brain Tumor Cells in Circulation are Enriched for Mesenchymal Gene Expression Cancer Discovery. Aug 19. pii: CD-14-0471.
  11. Hingtgen, S.D., Stuckey, D., Rich, B., Nesterenko, I., and Shah, K. Engineering toxin-resistant therapeutic stem cells to treat GBM. Stem Cells. Oct 24. doi: 10.1002/stem.1874. [Epub ahead of print]
  12. Srivastava, J., Robertson, CL., Rajasekaran, D., Gredler, R., Siddiq, A., Emdad, L., Mukhopadhyay, ND., Ghosh, S., Hylemon, PB., Gil, G., Bhere, D., Shah, K., Subler, MA., Windle, JJ., Fisher, PB and Sarkar, D. Astrocyte Elevated Gene-1 (AEG-1) Contributes to Hepatocellular Carcinoma by Regulating Retinoid X Receptor (RXR). Cancer Research. 2014; 74: 4364-77. doi: 10.1158/0008-5472.
  13. Zhu, Y., and Shah, K. Multiple genetic lesions in Receptor Tyrosine Kinase (RTK) pathway determine the response of brain tumor cells to PF299804, an irreversible pan-ERBB inhibitor. Cancer Biology and Therapy. 2014. 15(6). [Epub ahead of print]
  14. Du, W., Uslar, L. and Shah, K. Targeting c-Met receptor in overcomes TRAIL resistance in brain tumors. PLOS ONE. 2014; 9:e95490. doi: 10.1371/journal.pone.0095490.
  15. Stuckey, D., Shah, K. TRAIL on trial: preclinical advances for cancer therapy.Trends Mol Med.2013 Nov;19(11):685-94. doi: 10.1016/j.molmed.2013.08.007. Epub 2013 Sep 26.
  16. Duebgen, M., Martinez-Quintanilla, J., Tamura, K., Hingtgen, S., Redjal., N., Wakimoto, H., and Shah, K. Human Stem cells loaded with different variants of oHSV have antitumor effects in mouse models of intact and resected GBM. Journal of National Cancer Institute. 2014;106. pii: dju090. doi: 10.1093/jnci/dju090.
  17. Kuruppu, D., Brownell, A.L., Shah, K., Mahmood, U., Tanabe, K.K. Molecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability. Cancer Res. 2014 May 29. pii: canres.3472.2013. [Epub ahead of print.

Contact

Contact Us

Stem Cell Therapeutics and Imaging Program

  • Phone: (617) 724-8851

Khalid Shah, MS, PhD
Associate Professor, Harvard Medical School

Head, Molecular Neurotherapy and Imaging Laboratory
Director, Stem Cell Therapeutics and Imaging Program
Department of Radiology and Neurology
Massachusetts General Hospital

Principal Faculty, Harvard Stem Cell Institute

149 13th Street, Charlestown, MA 02129
Phone: (617) 726-4821 | Fax: (617) 643-7212

Email: kshah@mgh.harvard.edu

Web: http://shahmnil.mgh.harvard.edu
Twitter: https://twitter.com/StemCells4GBM
Facebook: https://www.facebook.com/stemcellsagainstcancer

Administrative Assistant

Anusha Venugopalan
Phone: (617) 724-8851 | Fax: (617) 643-7212
Email: avenugopalan@mgh.harvard.edu

 

 

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