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Research at Mass General
The Hoggatt Laboratory is broadly interested in the stem cell niche regulatory mechanisms that govern tissue regeneration, particularly regulation by macrophages, and has a specific interest in translational science for bone marrow transplantation and other treatments. Our laboratory has identified a unique “highly engraftable” hematopoietic stem cell that has applications for further probing of stem cell niche biology, and clinical applications in transplantation, gene therapy and other fields. We have also developed unique genetic mouse models allowing us to dynamically explore macrophage heterogeneity in a variety of disease settings.
Jonathan Hoggatt, PhDAssistant in Immunology, Department of Medicine, Massachusetts General HospitalInstructor in Medicine, Harvard Medical School
Jonathan Hoggatt, PhD, received his bachelor’s degree from Purdue University in pharmaceutical sciences and his master’s degree in biology from Indiana University. He then studied in the Department of Microbiology and Immunology at Indiana University School of Medicine, receiving his doctorate in hematology. His dissertation was awarded the Esther L. Kinsley award, the highest honor bestowed amongst doctoral work across all disciplines. Dr. Hoggatt then trained during a post-doctoral fellowship with David Scadden at Harvard University and Massachusetts General Hospital from 2011-2015.Dr. Hoggatt is an assistant professor of medicine at Harvard Medical School and Massachusetts General Hospital in both the Center for Transplantation Sciences and the Cancer Center. He is also a principal faculty member in the Harvard Stem Cell Institute and an affiliate faculty member of the Stem Cell and Regenerative Biology Department at Harvard University, where he teaches immunology. His research is translationally focused and has resulted in a number of clinical trials. His laboratory investigates the regulation of hematopoietic stem and progenitor cells, and he is interested in developing methods that facilitate engraftment and mobilization for transplant. Dr. Hoggatt also serves on the American Society of Hematology’s Committee of Government Affairs and Communications Committee and is a contributing editor to The Hematologist. He is a former police commissioner and city councilman. Learn moreView publicationsLaboratory ManagerShruti Datari Harvard University Undergraduate ResearcherHannah RasmussenPost-Doctoral FellowBin-Kuan Chou, PhD
The Hoggatt Laboratory leads the following projects:
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