Photo of Shannon Bromley

Shannon Bromley, PhD

The Bromley Laboratory investigates lymphocyte migration, with an emphasis on the mechanisms that regulate the accumulation of T cells within normal and inflamed non-lymphoid tissues.

Overview

Principal Investigator, Center for Immunology and Inflammatory Diseases

Assistant Professor of Medicine, Harvard Medical School

 

Lymphocyte recirculation is a dynamic and tightly regulated process necessary for delivery of effective immune responses.  While many memory T cells circulate through blood, a subset of memory T cells persists long-term within peripheral tissues.  Localization of T cells within peripheral tissues, such as skin, provides rapid defense against invading pathogens.  However, in some settings the local persistence of T cells may contribute to local, recurring autoimmune diseases.

We are currently using mouse models of infection (herpes simplex virus) and autoimmunity (vitiligo) to study the interstitial migration, differentiation, persistence and response of memory T cells within the skin.  We anticipate that these studies will define the contributions of cellular receptors and environmental factors to tissue-resident memory T cell differentiation and response.  Defining the mechanisms that control the accumulation and response of T cells within peripheral tissues may inform vaccine development, as well as identify novel targets to eliminate pathogenic T cells from peripheral tissues for treatment of autoimmune diseases.

Group Members

Principal Investigator:

  • Shannon Bromley, PhD

Postdoctoral Fellow:

  • Rut Mora Buch, PhD

Technician:

  • Alexandra Chasse

 

 

Research Projects

  • Regulation of tissue-resident memory T cell differentiation and response by adhesion receptors.
  • Role of the tissue microenvironment in regulating tissue-resident memory T cell differentiation and persistence.
  • Therapeutic targeting of resident memory T cells in autoimmune disease.

Research Positions

If you are interested in applying for postdoctoral position, please e-mail your CV and a list of references to: sbromley@mgh.harvard.edu.

Publications

Contact

Contact Us

Bromley Laboratory

CNY 149-8

149 13th Street Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-643-7718
  • Fax: 617-726-5651
  • Email Us

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