Laboratory of Oluwaseun Akeju, MD, MMSc

The Laboratory of Oluwaseun Akeju, MD, MMSc, is part of the Center for Neuroscience Studies of Anesthesia at Massachusetts General Hospital. The lab conducts research that intersects medicine, neuroscience, mathematical modeling and engineering.

Overview

The goal of the laboratory of Oluwasun Akeju, MD, MMSc, at Massachusetts General Hospital is to make surgery safer for patients by developing tools and strategies to optimize post-operative cognitive recovery.

The ability to perform surgery or invasive procedures safely and humanely relies on the delivery of general anesthesia—a practice that was first publicly demonstrated at Massachusetts General Hospital in 1846. General anesthesia is a reversible drug-induced state that consists of unconsciousness, amnesia, analgesia and immobility with maintenance of physiological stability. According to the New England Journal of Medicine, it is estimated that more than 60,000 patients in the United States receive general anesthesia every year for surgery. The brain, especially for older patients, often does not return to normal after general anesthesia. Some patients develop a serious deficit that comes and goes while others demonstrate a significant and persistent decline in performance on neuropsychological tests.

Our Research

Three major approaches of our research:

  1. Creating tests to preemptively identify patients at-risk for neurocognitive dysfunction after anesthesia, to enable our world-class team of doctors to selectively target at-risk patients for more focused care.
  2. Developing strategies, based on each patient’s neurophysiology, to personalize anesthetic care and limit drug over-dosage in the operating room.
  3. Studying the overlap between sleep and anesthesia in order to develop new drugs that are devoid of neurocognitive deficits, and instead offer the restorative benefits of natural sleep to patients.

See our list of recent publications

Interested in participating?

We are currently recruiting patients for the following studies:

  • Minimizing Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS) -  currently limited to patients over 65-years-old who are scheduled to have heart surgery at Mass General
  • Repurposing dexmedetomidine into an oral sleep therapeutic - currently limited to healthy volunteers 18-50 years of age
  • Additional studies of human neurophysiology and behavior during induction, maintenance and emergence from general anesthesia - typically limited to healthy volunteers 18-36 years of age

If you are interested in participating in any of the above studies, call us at 617-724-9857 or e-mail akejulab@mgh.harvard.edu

Lab Members

Principal Investigator

Oluwaseun Akeju, MD, MMSc

Research Team

  • Shubham Chamadia, PhD
    SUNY Buffalo
    Postdoctoral Research Associate
  • Jacob Gitlin, BS
    University of Massachusetts Amherst
    CRC I
  • Eunice Hahm, BS
    Cornell University
    CRC I
  • Lauren Hobbs, MS
    University of Massachusetts Amherst
    CRC II, CNSA
  • Reine Ibala, BS
    Yale University
    CRC II
  • Kara Pavone, BS, BSN, RN
    University of Pennsylvania
    Program Manager

Join the Lab

A postdoctoral position is currently available. If you are interested in being considered for a position, send an email to oluwaseun.akeju@mgh.harvard.edu.

Required qualifications for this position are:

  1. At least one first-authored paper in areas related to systems or computational neuroscience
  2. Research experience in one of these fields: neurophysiology, imaging, MATLAB (or equivalent) programming or computational statistics.

Preference will be given to applicants interested in research questions related to neuroscience.

Contact

Department of Anesthesia, Critical Care and Pain Medicine
Massachusetts General Hospital
Jackson 434
55 Fruit St
Boston MA 02114

For general inquiries, call 617-724-7200 or email akejulab@mgh.harvard.edu

For more information, visit the Department of Anesthesia, Critical Care and Pain Medicine.

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