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Research at Mass General
The laboratory of Farouc Jaffer, MD, PhD, in the Cardiovascular Research Center at Massachusetts General Hospital is developing bench-to-bedside approaches to image and understand in vivo inflammation and thrombogenesis in vascular disease, including atherosclerosis, venous thrombosis, and arteriovenous fistula.
Through close collaborations with molecular imaging chemistry experts, we have developed an array of molecular imaging agents to report on macrophages, fibrin, cathepsin K, VCAM-1, thrombin, and activated factor XIII. Using intravital microscopy, FMT, MRI or PET-CT, we have imaged and quantified these molecular targets in murine models of vascular disease, which have led to new insights into how atheroma, thrombi, and AVF evolve and resolve.
Our major translational efforts focus on developing intravascular near-infrared fluorescence molecular imaging catheter technology to image inflammation in human coronary arteries and coronary stents, using large animal models. In conjunction with world-leading engineering groups, we have developed intravascular NIRF-OCT and NIRF-IVUS catheters and systems. The ability to image inflammation at high-resolution could provide new approaches to identify high-risk plaques and high-risk stents.
Our clinical research efforts focus on improving percutaneous coronary intervention success for chronic total occlusions, radial artery catheterization, and improving the treatment of microvascular coronary disease and microvascular angina.
Farouc Jaffer MD, PhD Director, Coronary Intervention, Massachusetts General Hospital Director, Mass General Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) program Associate Physician, Mass General Cardiology, Department of Medicine
Daqing Li, MD, Post-doctoral Fellow (2017-present)Research: NIRAF-OCT of plaque progression.
Mohammed Chowdhury, MB, ChB, Post-doctoral Fellow (2017-present) Research: Molecular imaging of balloon injury and inflammation.
Mazen Albaghdadi, MD, MSc, Post-Doctoral Fellow (2017-present) Research: Molecular imaging of inflammation in cardiovascular disease and Medical device development.
Xiaoxin Zheng, MD, PhD, Post-doctoral Fellow (2017-present)Research: Molecular imaging of stent thrombosis.
Wenzhu Li, MD, Post-doctoral Fellow (2016-present) Research: Molecular imaging of venous thrombosis resolution and mechanisms of fibrinolysis.
Stephan Kellnberger, PhD, Post-doctoral Fellow (2014-present)Research: Molecular Thermo-acoustic imaging and Intravascular NIRF-IVUS imaging (Co-advisor Vasilis Ntziachristos, PhD).
Eric Osborn, MD, PhD,Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2013-present)Research: Molecular imaging of atherosclerosis and stent injury.
Jie Cui, MD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2014-present) Research: Imaging of inflammation and thrombosis in arteriovenous fistula.
Chase Kessinger, PhD, Post-doctoral Fellow; Instructor in Medicine, Harvard Medical School (2016-Present) Research: The role of inflammation in thrombus resolution.
Adam Mauskapf, BS,Lab Manager (2008-Present)
Adam Mauskapf has been the lab manager for the Jaffer Lab since 2012, and has been with the lab since 2008. He graduated from Bucknell University in 2007. He helps to run the large and small animal research labs and is the research surgeon for the large animal lab. Adam helps to manage the lab, set up surgery schedules, and do many other technical tasks. He has experience in catheterization techniques, micro- and macro-surgery, animal care, anesthesia monitoring, and other aspects of animal research.
Madeleine Grau, BS, Research Technician (2017-Present)
Purvish Patel, BS, Graduate Student (2006-2008)
Kiyuk Chang, MD, PhD, Associate Professor of Medicine, Catholic University, Seoul, Korea (2007-2009)
Ion Botnaru, MD, Cardiologist, Olympia, Washington (2008-2010)
Amit Saxena, PhD, Post-doctoral fellow, Albert Einstein University (2008-2010) Project: In vivo assessment of inflammation in vascular injury. Abstract presentation ATVB 2011.
Neha Jakete, BS, Graduate Student (2009)
Georgios Mallas, PhD, Senior Electrical Engineer, Draeger Medical (2009-2012)Research: Fluorescence reconstruction in hollow geometries.
Crystal Ripplinger, PhD, Assistant Professor of Medicine, University of California, Davis (2009-2010)
Amir Rosenthal, PhD, Professor, Technion Israel Institute of Technology (2009-2010)Research: Intravascular NIRF and optoacoustic imaging (Co-mentor with Dr. Vasilis Ntziachristos).
Marcella Calfon, MD, PhD, Assistant Professor of Medicine, UCLA (2009-2012)
Jin Won Kim, MD, PhD, Associate Professor of Medicine, Guro University, Seoul, Korea (2009-2011)
William Hucker, MD, PhD, Internal Medicine Resident (2010-2012)
Tetsuya Hara, MD PhD, Assistant Professor, Kobe University, Japan (2010-2014)Project: Molecular Imaging of Atherosclerosis and Thrombosis
Brian Thompson, PhD, Research Technician (2010-2011)
Yair Mega, MSc, Graduate Student (2011-2012)
Thomas Jetzfellner, PhD, Graduate Student (2011-2012)
Amr El Maghraby, MD, Internal Medicine Resident, Lutheran Medical Center, Brooklyn, New York (2011-2013)Research: Photodynamic therapy of macrophage-rich atherosclerosis. One manuscript in preparation.
Ashley Stein, BS, Medical Student, Harvard Medical School – HST program (2011-2015)Research: The role of inflammation in experimental plaque rupture.
Henry Jorge Zelada Castro, MD, Post-Doctoral Fellow (2012-2013)
Johan Verjans, MD, PhD, Cardiology Fellow, Utrecht, Netherlands (2012-2013)Research: Intracoronary molecular imaging.
Victor Guanming Qi, MD, PhD, Post-doctoral Fellow (2015-2017)Research: Nanotherapy for vascular disease.
Harkamal Jhajj, BD, Research Technician (2015-2017)
Lang Wang, MD, PhD, Assistant Professor, Department of Cardiology, Wuhan University (2016-2017) Research: Intravascular imaging of stent-plaque interactions.
Makoto Orii, MD, PhD, Post-doctoral Fellow; Assistant Professor Wakayama Medical University (2016-2018)Research: Molecular imaging of athero-thrombosis.
Massachusetts General Hospital Simches Research Building 185 Cambridge Street, 3206 Boston, MA 02114
Clinical Office (patient inquiries): 617-724-8052 Research Office: 617-724-9353 Fax: 617-860-3180
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