Transmission Electron Microscopy Core

The Transmission Electron Microscopy Core, part of the Neurosciences Center at Massachusetts General Hospital, aids in elucidating the complex architecture of the nervous system.

Overview

Core Functions
The transmission electron microscope (TEM) has been an essential tool for research in cell biology since its development in the 1950s and continues to aid in elucidating the complex architecture of the nervous system including membrane appositions between pre and postsynaptic structures, glia-neuron processes, glia-blood vessel contacts as well as the precise localization of membrane bound antigens by immunolabeling methods.

The TEM is equipped with a digital camera that produces high contrast images. The facility is supported by other equipment associated with TEM use including ultra microtomes for thin sectioning, diamond knives, and a vibratome.

Services include consultation, tissue processing, thin sectioning, and TEM analysis and image collection. Training for those interested in learning the techniques will be available.

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