Photo of Andrew D. Luster

Andrew D. Luster, MD, PhD

The Luster Laboratory at Massachusetts General Hospital investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.


Chief, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital
Director, Center for Immunology and Inflammatory Diseases
, Massachusetts General Hospital
E. Alexandria and Michael B. Altman Chair in Immunology, Massachusetts General Hospital
Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Harvard Medical School


The Luster Laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the trafficking of leukocytes in vivo. Gene-targeted and transgenic mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of inflammatory, autoimmune, allergic and infectious diseases. System biology approaches are being utilized to understand how multiple chemoattractant pathways are integrated in vivo for the fine control of leukocyte trafficking. In vivo multiphoton microscopy is being utilized to interrogate the function of chemokines in controlling the migratory and interactive behavior of T cells and dendritic cells in lymph nodes and peripheral tissue. We also study the regulation of chemokine production in vivo since this is a critical determinant of their role in a given biological response. We have a particular interest in the role of innate immune receptors, such as toll-like receptors, in regulating chemokine production in vivo. We are also interested in structure-function relationships of chemokines and their receptors as well as the molecular mechanism of chemokine signal transduction, as these are important questions relevant to chemotaxis and immune cell trafficking in health and disease. Finally, chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis.

Group Members

Principal Investigator:

  • Andrew D. Luster, MD, PhD

Assistant Professors:

  • Shannon Bromley, PhD
  • Sabina Islam, MD
  • Ahmad Sedaghat, MD, PhD

Research Staff:

  • Ben Michael, MBChB, MRCP, PhD


  • Maud Deruaz, PhD
  • Jason Griffith, MD, PhD
  • Mo Ling, MD
  • Carrie Sokol, MD, PhD

Postdoctoral Fellows:

  • Melvyn Chow, PhD
  • Lucas Faustino, PhD
  • Chie Miyabe, MD, PhD
  • Yoshi Miyabe, MD, PhD
  • Aleksandra Ozga, PhD
  • Rod Rahimi, MD, PhD
  • Elizabeth Sorensen, PhD

Graduate Student:

  • Jeff Lian

Senior Laboratory Manager:

  • Carol P. Leary


  • Ryan Camire
  • Sophina Ji
  • Akiba Sato

Luster Lab Alumni

Research Projects

  • Chemokines and lipid mediators in the regulation of T cell and dendritic cell migratory behavior in the lymph node and peripheral tissue
  • Chemokines and lipid mediators in the regulation of T cell and eosinophil trafficking and function in allergic inflammation, such as asthma and atopic dermatitis
  • Chemokines and lipid mediators in the regulation of leukocyte trafficking into the joint in rheumatoid arthritis
  • HIV immune pathogenesis and vaccine development in humanized mice
  • Chemokines and lipid mediators in the regulation of fibrosis
  • Structure function studies of chemokines
  • Biochemical and genetic dissection of chemokine receptor signal transduction
  • Toll-like receptor (TLR) regulation of chemokine and chemokine receptor expression
  • TLR function in autoimmune diseases, such as systemic lupus erythematosus
  • Chemokines and lipid mediators in the regulation of transplantation rejection
  • Chemokines and lipid mediators in atherosclerosis
  • Chemokines in microglial function and trafficking in Alzheimer's Disease

Research Positions

If you are interested in applying for a postdoctoral position, or are a Harvard PhD student interested in a laboratory rotation, please e-mail your CV (for student and postdoctoral) and reference letters (for postdoctoral)



Contact Us

Luster Laboratory

CNY 149-8

149 13th Street Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-726-5710
  • Fax: 617-726-5651
  • Email Us

Senior Executive Assistant - Diane Qualters

Phone: 617-724-6147

Senior Laboratory Manager - Carol Leary

Phone: 617-724-4992

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