The Rheumatology Clinical Research Unit (RCRU) at Massachusetts General Hospital (MGH) is directed by John Stone, MD, MPH. The RCRU is located on the second floor of the Yawkey Building within Rheumatology Associates, consistent with the philosophy that clinical research needs to be brought to patients. The RCRU is staffed by clinical investigators whose interests range broadly and include systemic lupus erythematosus (SLE), systemic vasculitis, gout, Lyme disease, rheumatoid arthritis (RA), Sjögren’s syndrome, osteoarthritis, IgG4-related systemic disease, and metabolic bone disease (Paget’s disease, osteoporosis). The RCRU has a close relationship with the Mass General Clinical Research Center, which provides study coordinators, biostatistical analysis, trial design consultation, and data management services.
The major focus of the RCRU is "translational research", i.e., the type of investigation that applies breakthroughs in the laboratory directly to medical diseases in human patients. Recent examples of the types of work at the MGH include:
The RCRU has developed productive collaborations with the Center for Inflammatory and Immunological Diseases (CIID), ensuring that state-of-the-art scientific techniques are brought from the laboratory bench to the patient’s bedside for the purposes of more efficient diagnosis and more effective therapies.
Studies currently recruiting:
Stone JH, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CGM, St. Clair EW, Turkiewicz A, Tchao NK, Webber L, Ding L, Sejismundo LP, Mieras K, Weitzenkamp D, Ikle D, Seyfert-Margolis V, Mueller M, Brunetta P, Allen NB, Fervenza FC, Geetha D, Keogh KA, Kissin EY, Monach PA, Peikert T, Stegeman C, Ytterberg SR and Specks U, for the RAVE-ITN Research Group. N Engl J Med 2010; 363: 221-32.
Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Nature 2010; 466 : 243-7.
Steere AC, Drouin EE, Glickstein LJ. Clin Infect Dis. 2011; 52: s259-65.
Seward RJ, Drouin EE, Steere AC, Costello CE. Mol Cell Proteomics 2011; 10: M110.002477.
Ramos-Casals M, Tzioufas AG, Stone JH, Siso A, Bosch X. JAMA 2010; 304: 452-60.
Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. Arthritis & Rheum 2010; 62: 2127-37.
Branda JA, Aguero-Rosenfeld ME, Ferraro MJ, Johnson BJ, Wormser GP, Steere AC. Clin Infect Dis. 2010; 50: 20-6.
Dahlgren M, Khosroshahi A, Nielsen GP, Deshpande V, Stone JH. Arthritis Care & Research 2010; 62: 1312-8.
Khosroshahi A, Bloch DB, Deshpande V, Stone JH. Arthritis & Rheum 2010; 62: 1755-62.