Clinical Immunology Laboratory

The Clinical Immunology Laboratory provides both diagnostic and educational services to the Mass General community.

About This Procedure

The Clinical Immunology Laboratory offers a full range of clinical diagnostic services, including agarose gel electrophoresis, immunoelectrophoresis and immunofixation to detect monoclonal proteins in serum, urine and cerebrospinal fluid. Other tests include indirect immunofluorescence, assay for detection of antinuclear antibodies, anti-native DNA antibodies, identification and characterization of cryoglobulins, detection of precipitin antibodies for hypersensitivity pneumonitis. Utilizing ELISA assays the laboratory performs assays for SS-A, SS-B, Sm, RNP, anti-Scl-70 and Jo-1, anti-CCP, a full panel of tTG IgA and IgG antibodies for celiac disease, and H.Pylori.  Utilizing rate nephelometry quantitation of serum and urine free light chains are performed and data coupled to interpretations of serum and urine electrophoresis and immunofixation analyses. Both IgA and IgM hevy-lite quantitative assays are performed to monitor IgA and IgM monoclonal gammopathies that preclude precise quantitation by immunofixation. Serum IgG subclasses are measured by nephelometry. Evaluation of complement proteins, complement activation, determination of serum viscosity and analyses of joint fluid crystals are also performed. Quantitation of 24 hour urine for Bence-Jones proteins and Hevy-lite assays are performed to meet requirements of clinical trials in multiple myeloma.

The application and clinical value of these tests are highlighted in the laboratory teaching sessions to residents and fellows in various fields of medicine by the Director during daily reporting and resulting sessions.

Results are available on the Clinical Application Suite (CAS), Longitudinal Medical Record (LMR), and EPIC as soon as they are verified and signed off by the Director. Written results are sent to the Requesting Area and the Medical Records Room.

 

Director, Clinical Immunology Laboratory - Mandakolathur Murali, MD

Location - Bulfinch 422; Hours of operation - Monday-Friday, 8:30am-5:00pm

 

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