Past Projects

Principal Investigator: Schwamm, Lee H., M.D.
End Date: January 2007

Summary: DIAS-2 was a prospective, randomized, double-Blind, placebo-Controlled, single Bolus, multinational, multicenter, parallel group, dose-ranging study of desmoteplase (INN) in the indication of acute stroke. Massachusetts General Hospital was the participating site for this trial and was a highest enrolling site in North America.

Online Publications

• Topline Results of Phase III Study in Acute Ischemic Stroke (Dias-2) Do Not Demonstrate Difference Between Desmoteplase and Placebo - Forest Laboratories, Inc.

Principal Investigator: Rordorf, Guy A., M.D.

Summary: Study of efficacy of induced hypertension to improve neurologic deficit in acute stroke patients by increasing brain blood flow.

Online Publications

• Pharmacological Elevation of Blood Pressure in Acute Stroke: Clinical effects and safety - stroke.ahajournals.org
• A pilot study of drug-induced hypertension for treatment of acute stroke - www.neurology.org

Principal Investigators: Gazelle, Scott, M.D., Ph.D., Furie, Karen, M.D., Gleason, Suzanne, Ph.D., and Koroshetz, Walter J., M.D.

Summary: Center for Innovative and Minimally Invasive Therapy/ Department of Defense funded study of the cost of stroke and the benefit that may accrue from new therapies to reduce disability.

Publications

• Potential Influence of Acute CT imaging on inpatient costs in ischemic stroke - Trinity College
• Effect of implementing an evaluation and treatment protocol compliant with NINDS recommendations

Principal Investigators: Greenberg, Steven, M.D., Ph.D., Furie, Karen, M.D., and Stein, Joel, M.D.
Start Date: November 1999
End Date: October 31, 2003

Online Publications

• Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage

Principal Investigators: Furie, Karen, M.D. and Kistler, Philip, M.D.

Summary: NIH sponsored randomized double-blind placebo-controlled trial of family intervention in stroke recovery.

Online Publications

• Primary Study Results - Psychosomatic Medicine
• Lesion Characteristics, NIH Stroke Scale, and Functional Recovery After Stroke - American Journal of Physical Medicine and Rehabilitation

Principal Investigator: Moskowitz, Michael, M.D.

Summary:Goal is to better understand the molecular mechanisms that underlie ischemic stroke.

Online Publications

• None available