Since being appointed to the clinical staff at MGH in 2001, I have played a major role in the following clinical projects at MGH.
The induction of donor-specific tolerance is currently one of the most important goals of organ or cell transplantation.
Based on our rodent studies on mixed chimerism, we developed a clinically relevant non-myeloablative preparative regimen to induce mixed chimerism and renal allograft tolerance following donor bone marrow transplantation in MHC fully-mismatched cynomolgus monkeys. This approach has been successfully extended to HLA mismatched kidney transplant recipients. In 4/5 recipients who were treated with our mini-bone marrow transplant, immunosuppression was successfully discontinued at 9-14 months following the transplant in the other four recipients with longest survival exceeding 7 years. Since January 2009, an expanded, multi-center clinical trial for tolerance induction following HLA mismatched kidney transplantation has been underway.
A total of 110 peer-reviewed manuscripts, 57 Reviews and 12 Textbook chapters have been published as of Dec 2009. Representative publications are following;
Eight years ago, Jennifer Searl used a handicapped permit to get around campus at the University of New Hampshire. Last October, Searl, 26, ran a half-marathon and felt so good afterward she immediately signed up for another. In between these two extremes lies not only a journey of a thousand steps, but one taken along a path Searl herself blazed - with help from the Massachusetts General Hospital Transplant Center.
MGH Hotline 12.17.10 In General Awards and Honors
Chain 124. That’s the name of a record-breaking kidney transplant chain.
John Marzelli and Esperanza Yoblonsky were suffering from IgA nephropathy and both needed a new kidney; they found the answer in the Mass General Transplant Center’s internal exchange program.
Tatsuo Kawai, MD, PhD, a transplant surgeon and surgical director of the Dialysis Access Program, was honored as the first incumbent of the A. Benedict Cosimi Endowed Chair during an April 13 ceremony in the Trustees Room.
Phone 2: 617-724-9996