Transplantation Biology Research Center

The Transplantation Biology Research Center (TBRC) at Massachusetts General Hospital conducts critical research to increase the success rates of transplantation and meet the growing demand for organ and bone marrow transplantation.

Cardiothoracic Transplantation Laboratory
Cardiothoracic Transplantation Laboratory

The Cardiothoracic Transplantation Laboratory at Massachusetts General Hospital uses state-of-the-art molecular and cellular techniques to study transplantation tolerance, acute/chronic rejection, innate immunity, xenotransplantation and whole organ bioengineering for heart and lung transplantation models.

Experimental Organ Transplantation Laboratory
Experimental Organ Transplantation Laboratory

The Experimental Organ Transplantation Laboratory in the Massachusetts General Hospital Transplantation Biology Research Center focuses on developing tolerance-inducing strategies utilizing a preclinical model of pig-to-baboon xenotransplantation.

Genetic Engineering Laboratory
Genetic Engineering Laboratory

The Genetic Engineering Laboratory in the Transplantation Biology Research Center (TBRC) focuses on understanding the immune response to porcine xenografts, engineering swine for use as solid organ xenotransplantation donors and developing porcine stem cells for use in large animal models of potential stem cell therapies.

Hematopoietic Cell Transplantation Laboratory
Hematopoietic Cell Transplantation Laboratory

The Hematopoietic Cell Transplantation Laboratory in the Transplantation Biology Research Center studies the immunology of hematopoietic cell transplantation with the goal of eliminating immunological barriers in patients with cancers and other diseases that affect the blood, bone marrow and lymph nodes.

Large Animal Organ Transplantation Section
Large Animal Organ Transplantation Section

The Large Animal Organ Transplantation Section in the Transplantation Biology Research Center at Massachusetts General Hospital comprises three laboratories investigating tolerance induction in transplantation.

Molecular Biology Laboratory
Molecular Biology Laboratory

The Molecular Biology Laboratory in the Transplantation Biology Research Center at Massachusetts General Hospital focuses on deciphering the role of major histocompatibility class II molecules in the modulation of T cell responses to self and foreign antigens.

Organ Transplantation Tolerance and Xenotransplantation Laboratory
Organ Transplantation Tolerance and Xenotransplantation Laboratory

The Organ Transplantation Tolerance and Xenotransplantation Laboratory in the Transplantation Biology Research Center works to develop strategies to induce tolerance across allogeneic and xenogeneic barriers to prevent rejection and relieve the current shortage of donor organs.

Recombinant Protein Expression and Purification Core
Recombinant Protein Expression and Purification Core

The Recombinant Protein Expression and Purification (RPrEP) Core in the Transplantation Biology Research Center at Massachusetts General Hospital provides cost-effective resources for expression and purification of recombinant proteins necessary for preclinical and basic mechanistic studies by immunologists and cancer biologists.

Turka Laboratory
Turka Laboratory

The Turka Laboratory in the Transplantation Biology Research Center at Massachusetts General Hospital investigates the cellular and molecular aspects of T cell tolerance, with a particular interest in mechanisms of transplant tolerance.

Vascularized Composite Allotransplantation Laboratory
Vascularized Composite Allotransplantation Laboratory

The Vascularized Composite Allotransplantation Laboratory in the Massachusetts General Hospital Transplantation Biology Resource Center investigates the immunobiology of vascularized composite allografts with a primary focus on developing tolerance induction strategies in preclinical models.


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