Center for Transplantation Sciences

The Center for Transplantation Sciences (CTS) at Massachusetts General Hospital conducts critical research to increase the success rates of transplantation and meet the growing demand for organ and bone marrow transplantation.

Alessandro Alessandrini, PhD Alessandrini Laboratory
The Alessandrini Laboratory in the Center for Transplantation Sciences (CTS) uses a mouse model to study the elucidation of regulatory T cells and plasmacytoid dendritic cells and the roles they play in the induction of allograft acceptance.
 
Gilles Benichou, PhD, DSc Benichou Laboratory
The Benichou Laboratory in the Center for Transplantation Sciences (CTS) studies the immune mechanisms underlying the allorecognition and alloresponse by T and B cells in transplant rejection and tolerance.
 
Joren C. Madsen, MD, DPhil Cardiothoracic Transplantation Laboratory
The Cardiothoracic Transplantation Laboratory in the Center for Transplantation Sciences (CTS) uses state-of-the-art molecular and cellular techniques to study transplantation tolerance, acute/chronic rejection, innate immunity, xenotransplantation and whole organ bioengineering for heart and lung transplantation models.
 
Robert B. Colvin, MD Colvin Laboratory
The Colvin Laboratory in the Center for Transplantation Sciences (CTS) focuses on the mechanisms of allograft rejection and acceptance in animal and human studies, as revealed by pathologic, immunopathologic and molecular techniques.
 
Cosimi/Kawai Laboratory Cosimi/Kawai Laboratory
The Cosimi/Kawai Laboratory in the Center for Transplantation Sciences (CTS) focuses on allograft tolerance induction in nonhuman primates and humans, with the goal of developing safe and reliable tolerance inducing regimens applicable to clinical transplantation.
 
Robert J. Hawley, PhD Genetic Engineering Laboratory
The Genetic Engineering Laboratory in the Center for Transplantation Sciences (CTS) focuses on understanding the immune response to porcine xenografts, engineering swine for use as solid organ xenotransplantation donors and developing porcine stem cells for use in large animal models of potential stem cell therapies.
 
Christene A. Huang, PhD Hematopoietic Cell Transplantation Laboratory
The Hematopoietic Cell Transplantation Laboratory in the Center for Transplantation Sciences (CTS) studies the immunology of hematopoietic cell transplantation with the goal of eliminating immunological barriers in patients with cancers and other diseases that affect the blood, bone marrow and lymph nodes.
 
James I. Kim, PhD Kim Laboratory
The Kim Laboratory in the Center for Transplantation Sciences (CTS) examines the hypothesis that a small subset of B cells plays a beneficial or regulatory role in transplant tolerance.
 
James S. Allan, MD Madsen/Allan Laboratory
The Madsen/Allan Laboratory in the Center for Transplantation Sciences (CTS) investigates mechanisms of rejection and tolerance in preclinical models of heart and lung transplantation.
 
James F. Markmann, MD, PhD Markmann Laboratory
The Markmann Laboratory in the Center for Transplantation Sciences (CTS) focuses on defining the role of regulatory B cells in transplantation tolerance by examining the effect of Breg expression of TGF-b and the critical interaction of Bregs and Tregs in generating tolerance.
 
Christian LeGuern, PhD Molecular Biology Laboratory
The Molecular Biology Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on deciphering the role of major histocompatibility class II molecules in the modulation of T cell responses to self and foreign antigens.
 
Kazuhiko Yamada, MD, PhD Organ Transplantation Tolerance & Xenotransplantation Laboratory
The Organ Transplantation Tolerance and Xenotransplantation Laboratory in the Center for Transplantation Sciences (CTS) works to develop strategies to induce tolerance across allogeneic and xenogeneic barriers to prevent rejection and relieve the current shortage of donor organs.
 
David H. Sachs, MD The Transplantation Biology Research Center (TBRC) Laboratories
The TBRC Laboratories in the Center for Transplantation Sciences (CTS) comprises two laboratories (Genetic Engineering Laboratory & Organ Transplantation Tolerance and Xenotransplantation Laboratory) and a swine breeding facility investigating tolerance induction in transplantation and xenotransplantation, utilizing partially inbred miniature swine and non-human primates as preclinical large animal models.
 
Laurence A. Turka, MD Turka Laboratory
The Turka Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital investigates the cellular and molecular aspects of T cell tolerance, with a particular interest in mechanisms of transplant tolerance.
 
Parsia A. Vagefi, MD Vagefi Laboratory
The Vagefi Laboratory in the Center for Transplantation Sciences (CTS) focuses on developing tolerance-inducing strategies utilizing a preclinical model of pig-to-baboon xenotransplantation.
 
Curtis L. Cetrulo, Jr., MD Vascularized Composite Allotransplantation Laboratory
The Vascularized Composite Allotransplantation Laboratory in the Center for Transplantation Sciences (CTS) investigates the immunobiology of vascularized composite allografts with a primary focus on developing tolerance induction strategies in preclinical models.
 
Zhirui Wang, DVM, PhD Wang Laboratory
The Wang Laboratory in the Center for Transplantation Sciences (CTS) uses an unique diphtheria toxin-resistant yeast Pichia Pastoris expression system as a platform to develop diphtheria toxin-based recombinant immunotoxins/fusion toxins for specific depletion of targeted cell populations in vivo.
 
Heidi Yeh, MD Yeh Laboratory
The Yeh Laboratory in the Center for Transplantation Sciences (CTS) works on developing liver xenotransplantation to support liver regeneration, and ex vivo machine perfusion to improve steatotic livers to transplantability.