The Large Animal Organ Transplantation Section in the Transplantation Biology Research Center (TBRC) at Massachusetts General Hospital comprises three laboratories:
These laboratories utilize partially inbred miniature swine as preclinical large animal models in allotransplantation studies. Three herds of miniature swine homozygous for different sets of histocompatibility antigens at the major histocompatibility complex (MHC) have been developed by David H. Sachs, MD, Scientific Director of the TBRC, over the past 40 years. These animals show many similarities to human beings, both immunologically and physiologically, facilitating their potential use both as a model for allotransplantation studies and as xenograft donors.
David H. Sachs, MD
Scientific Director, Transplantation Biology Research Center
Head, Large Animal Organ Transplantation Section, TBRC
Immunologist, Massachusetts General Hospital
Paul S. Russell/Warner-Lambert Professor of Surgery, Harvard Medical School
Rebecca Brophy, Staff Assistant III
David H. Sachs, MD, graduated from Harvard College in 1963, summa cum laude, with a Bachelor of Arts in chemistry, in 1964 with a DES in organic chemistry from the University of Paris and in 1968 with a Doctor of Medicine, magna cum laude, from Harvard Medical School.
From 1968 to 1970, Dr. Sachs trained as a surgical intern and research fellow in transplantation at Massachusetts General Hospital. He then moved to the National Institutes of Health, where he developed a program in transplantation research. In 1991, he returned to Mass General as director of the Transplantation Biology Research Center and the first Paul S. Russell/Warner-Lambert Professor of Surgery at Harvard Medical School.
Dr. Sachs has published more than 700 articles in scientific journals. His research achievements include:
Dr. Sachs is one of the three North American editors of Transplantation and was the founding editor of Xenotransplantation.
Dr. Sachs was elected to the Institute of Medicine of the National Academy of Sciences in 1996. He has received the Jean Borel Award in Transplantation, the ASTP/Novartis Established Investigator Award, The Medical Foundation Award and the Roche Ernest Hodge Memorial Award (formerly called the Roche AST Distinguished Achievement Award), the highest award bestowed by the American Society of Transplantation. Dr. Sachs was awarded an Honorary Degree from University of Nantes, France (2006), the Martin Prize for Excellence in Clinical Research (2009) and the Starzl Prize (2011).
Robert J. Hawley, PhD
Parsia Vagefi, MD
Kazuhiko Yamada, MD, PhD
John Hanekamp, MD, PhD
The Large Animal Organ Transplantation Section leads the following projects:
Eight years ago, Jennifer Searl used a handicapped permit to get around campus at the University of New Hampshire. Last October, Searl, 26, ran a half-marathon and felt so good afterward she immediately signed up for another. In between these two extremes lies not only a journey of a thousand steps, but one taken along a path Searl herself blazed - with help from the Massachusetts General Hospital Transplant Center.
MGH Hotline 3.06.09 Two MGH research teams received the first annual Joseph B. Martin Research Awards at the Feb. 11 Celebration of Science Colloquium dinner held in conjunction with the annual Scientific Advisory Committee meeting.
The first successful replantation of a human limb took place at the MGH in 1962. Now, nearly 50 years later, the Division of Plastic and Reconstructive Surgery is in the process of reviewing potential candidates for the latest in medical advances – hand transplantation surgery.
The 10th anniversary celebration of transplant tolerance induction brought together patients with their MGH physicians, nurses and other staff members involved in the program.
After more than two decades of leading the MGH Transplantation Biology Research Center (TBRC), David H. Sachs, MD, is stepping down from his role as director.