The Organ Transplantation Tolerance and Xenotransplantation Laboratory in the Transplantation Biology Research Center (TBRC) at Massachusetts General Hospital works to develop strategies to induce tolerance across both allogeneic and xenogeneic barriers in large animals with the ultimate goal of developing clinical tolerance induction protocols. Our current major projects include:
Our lab has also extended this technique to islet transplantation. We have developed a method for transplantation of islets as a vascularized graft (islet-kidney). Life-supporting islet-kidneys from single donors achieved glucose regulation and maintained normal renal function in both pigs and non-human primates that were treated with tolerance-inducing regimens. This promising technique may be the basis for future clinical protocols for the treatment of diabetic nephropathy.
Kazuhiko Yamada, MD, PhD
Senior Investigator/Head Organ Transplantation Tolerance and Xenotransplantation Laboratory,
Director, Surgical Research, TBRC
Associate Immunologist, Massachusetts General Hospital
Associate Professor of Surgery, Harvard Medical School
Kazuhiko Yamada, MD, PhD, is the director of surgical research and head of the Organ Transplantation Tolerance and Xenotransplantation Laboratory in the Transplantation Biology Research Center (TBRC) at Massachusetts General Hospital. He obtained his medical degree and a Doctor of Philosophy from Nippon Medical School in Japan and is a board-certified urologist. He was a research associate at the TBRC, under the direct supervision of David H. Sachs, MD, in late 1993. In 1997, he became a group leader in the Large Animal Transplantation Section and an instructor of surgery at Harvard Medical School. In 2000, he was promoted to assistant professor of surgery at Harvard Medical School and assistant immunologist at Mass General. In 2004, he was promoted to associate professor of surgery at Harvard Medical School.
Dr. Yamada has performed more than 800 cases of allogeneic and xenogeneic kidney transplantation in large animal models and has published more than 130 articles in these fields. He is a member of the American Society of Transplantation, the Transplantation Society and a council member of Xenotransplantation, as well as several other transplantation, urology and dialysis societies in Japan.
Dr. Yamada's current research interests focus on finding new means for inducing tolerance to allogeneic and xenogeneic organ transplants.
Akihiro Kawai, MD
The Organ Transplantation Tolerance and Xenotransplantation Laboratory leads the following projects: