The Genetic Engineering Laboratory in the Transplantation Biology Research Center at Massachusetts General Hospital is dedicated to:
- Alleviating shortages of solid organs through the development of porcine organs compatible with human transplantation by minimizing species incompatibilities between swine donors and human recipients
- Developing and testing protocols for clinical xenotransplantation in preclinical animal models. These protocols are designed to address both species incompatibility as well as the role of immune tolerance in reducing the need for long-term immunosuppressive drug therapy in conjunction with xenotransplantation.
In addition to studies focusing on issues specific to xenotransplantation, we are working to adapt allograft tolerance protocols being developed in other TBRC laboratories to the specific needs of xenotransplantation.