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Tatsuo Kawai, MD, PhD is a transplant surgeon and Co-Head of Abdominal Organ/Cell Transplantation Laboratory (Cosimi/Kawai Lab)at the Center for Transplantation Sciences.
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MassGeneral Hospital for Children
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Tatsuo Kawai MD, PhD is Professor of Surgery Harvard Medical School and A. Benedict Cosimi Chair in Transplant Surgery at Massachusetts General Hospital. He is also the Surgical Director of living donor transplantation and the dialysis access program. He specializes in kidney, pancreas and liver transplantation as well as hemodialysis access surgery. He received his M.D. from Nihon University School of Medicine and Ph.D. from Tokyo Women’s Medical University, Tokyo, Japan. He completed surgical residency at Tokyo Women’s Medical University and clinical fellowship at Massachusetts General Hospital. His clinical and research interests are primarily focused on development of methods to induce immunological tolerance in organ/cell transplantation. He was the first to report a consistent model for induction of renal allograft tolerance in nonhuman primates through a mixed chimerism approach. This and subsequent pre-clinical reports have extended this approach to the world’s first clinical trials for induction of renal allograft tolerance in HLA mismatched kidney transplantation. This is a seminal achievement of a clinical protocol leading to the first reproducibly successful induction of renal allograft tolerance in humans and was reported in the New England Journal of Medicine in 2008 and 2013. He was awarded the Martin Research Prize at MGH in 2009 and the New Key Opinion Leader Award by the Transplantation Society in 2010 for this work.
The induction of donor-specific tolerance is currently one of the most important goals of organ or cell transplantation.
Based on our rodent studies on mixed chimerism, we developed a clinically relevant non-myeloablative preparative regimen to induce mixed chimerism and renal allograft tolerance following donor bone marrow transplantation in MHC fully-mismatched cynomolgus monkeys. This approach has been successfully extended to HLA mismatched kidney transplant recipients. In 4/5 recipients who were treated with our mini-bone marrow transplant, immunosuppression was successfully discontinued at 9-14 months following the transplant in the other four recipients with longest survival exceeding 7 years. Since January 2009, an expanded, multi-center clinical trial for tolerance induction following HLA mismatched kidney transplantation has been underway.
View my most recent publications at PubMed
A total of 124 peer-reviewed manuscripts, 57 Reviews and 17 Textbook chapters have been published as of Dec 2009. Representative publications are following;
Tatsuo Kawai, MD, PhD, a transplant surgeon and surgical director of the Dialysis Access Program, was honored as the first incumbent of the A. Benedict Cosimi Endowed Chair during an April 13 ceremony in the Trustees Room.
John Marzelli and Esperanza Yoblonsky were suffering from IgA nephropathy and both needed a new kidney; they found the answer in the Mass General Transplant Center's internal exchange program.
Chain 124. That's the name of a record-breaking kidney transplant chain.
MGH Hotline 12.17.10 In General Awards and Honors
Eight years ago, Jennifer Searl used a handicapped permit to get around campus at the University of New Hampshire. Last October, Searl, 26, ran a half-marathon and felt so good afterward she immediately signed up for another. In between these two extremes lies not only a journey of a thousand steps, but one taken along a path Searl herself blazed - with help from the Massachusetts General Hospital Transplant Center.
An ultrasound at 19 weeks showed that Andrew Johnson would be born with kidney functionality complications. Fortunately for Andrew, his mother was a compatible donor, and when he was strong enough, Andrew underwent kidney transplantation at MassGeneral Hospital for Children Transplant Center. “Everyone was so nervous that day,” Tara Johnson states. “I was elated.”
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