Treatment Programs


Heart Transplant Program

The Heart Transplant Program at the Massachusetts General Hospital Transplant Center offers comprehensive treatment, transplantation and care management options for patients with heart failure and other severe heart conditions.

Leaders in Complex Cardiac Care

The Heart Transplant Program in the Massachusetts General Hospital Transplant Center comprises leading heart experts from the Mass General Corrigan Minehan Heart Center to draw on state-of-the-art technology, leading medical and surgical interventions, and more than two decades of experience to provide patients with individualized care before and after their heart transplant.

Our Heart Transplant Program has been recognized for innovation and excellence since completing our first heart transplant in 1985. Our multidisciplinary team includes leading cardiologists and surgeons who provide comprehensive treatment to patients who require transplantation due to a variety of complex conditions, including:

  • Cardiac amyloidosis: A condition in which abnormal protein builds up in the heart. Mass General is one of only seven hospitals in the United States performing cardiac amyloid transplants 
  • Cardiomyopathy: Any disease of the heart muscle in which the heart loses its ability to pump blood effectively
  • Heart failure: Also known as congestive heart failure, this condition occurs when the heart cannot pump enough oxygenated blood to meet the other organs’ needs
  • Chronic heart conditions that do not respond to other therapies

We are also a destination for patients who require multiple organ transplants and advanced care options, including stem cell transplantation.

Coordinated Care and Support Throughout the Transplantation Process

Comprehensive Evaluation and Orientation
As a patient in the Heart Transplant Program, your care begins with a comprehensive evaluation to determine if transplantation is your best treatment option. A transplant coordinator will help you through the evaluation process, gathering any necessary medical information and coordinating any needed tests or appointments, including a patient orientation. Learn more about the Heart Transplant Program evaluation process 

After evaluation, eligible heart transplant patients are placed on the national United Network of Organ Sharing (UNOS) waiting list, which manages the distribution of organs nationwide. In the New England region, the waiting list is managed by the New England Organ Bank. Learn more about the heart transplant waiting list 

Pre-transplant Care
Your Heart Transplant Program care team will work with you and your physician to address health care issues that might develop as you wait for your transplant. Treatment options such as mechanical circulatory devices may be recommended as a bridge to transplantation. Learn more about pre-transplant care 

Follow-up Care for a Lifetime
Our commitment to your well-being extends to your postoperative care. We will help you arrange for stays at intermediate care facilities, or implement home services, following discharge. Learn more about post-transplant care

Advancing Heart Failure Therapies and Transplantation


Support the Mass General Transplant Center

Support us

To learn more about how you can support the Heart Transplant Program, contact James F. Markmann, MD, PhD, at 617-643-4533

To make a gift now, please contact Tyrone C. Latin in Mass General Development at 617-643-5781 or make a donation online

The Mass General Heart Transplant Program is a regional research center with an active clinical trials program. Researchers in the Heart Transplant Program are involved in a wide variety of clinical trials of new pharmacological agents for the management of heart failure and heart transplantation. Learn more about research and available clinical trials

A Dedicated Referral Line for Physicians and Patients

We provide patients and referring physicians with an experienced access coordinator, a clinician who helps assess patient needs, coordinate appointments and begin the appropriate testing regimen.

To schedule an appointment or refer a patient, call 866-644-8910 or request an appointment online

Collaborative Care at Every Stage

The Mass General Heart Transplant team guides patients through every stage of care with a multidisciplinary team of doctors, nurses, dietitians, case managers, financial coordinators and other clinicians to help navigate the transplant process. Learn more about the heart transplant team 


Conditions and Diseases

The links below provide more information about conditions and diseases that might be treated within this program.


Cardiomyopathy is any disease of the heart muscle in which the heart loses its ability to pump blood effectively.

Congenital Heart Defects

Congenital heart defects occur when the heart or related blood vessels do not develop properly before or at birth.

Heart Failure

Heart failure, also called congestive heart failure, is a condition in which the heart cannot pump enough oxygenated blood to meet the needs of the body's other organs.

Support and Wellness

The Transplant Center is dedicated to ensuring that people understand their health care choices and have the necessary information to make decisions affecting their health and well being. The related support and wellness information listed below can play a role in treatment options.


A Patient Guide to Transplantation (PDF)

Read the Transplant Center's award-winning patient education guide, Transplantation: What Do I Need to Know?

¿Qué necesito saber? (PDF)

En español.

The following related clinical trials and research studies are currently seeking participants at Massachusetts General Hospital. Search for clinical trials and studies in another area of interest.

Transplant Center patients and donor families celebrate National Donate Life Month

The Transplant Center celebrated Donate Life Month by raising public awareness about the importance of organ donation and also extending thanks to the many organ donors and families who have given the generous gift of life to others.

Transplant Center recognized as a leader in patient education

Clinicians at the Transplant Center received a National Health Information Award for developing an outstanding patient education book and streamlining the patient evaluation process.

MGH joins study of new heart-assist device

MGH Hotline 9.17.10 The MGH recently became the fifth site nationwide to participate in the study of an innovative rotary blood pump for late-stage heart failure patients.

Neighborhood support inspires transplant recipient John Morelli to help others

A local community’s support for a transplant recipient motivated him to create an organization that helps others.

The journey home

Lacy Neff, a radio broadcaster from West Virginia, recently underwent a heart transplant as part of his treatment plan for amyloidosis, a rare disease that occurs when amyloid proteins accumulate in the organs. The MGH is one of only seven hospitals in the United States studying cardiac amyloid transplants – and the only one in the Northeast.

A heart transplant patient story: Mike Slama

For most of his life, Mike Slama has lived with a heart condition that could only be cured with transplantation. Listen to Mike share how his life changed when he received a new heart at the Massachusetts General Hospital Transplant Center.

Frank Robinson's Story

Watch 46-year-old Frank Robinson tell the story of his life-saving experience at Mass General after a massive coronary.

"Heart in a box" gives new life

For two years, Amy DeStefano struggled with increasing heart complications, leaving her needing a heart transplantation. Through one of Mass General’s clinical trials, Amy became the first person in New England to receive a "heart in a box" transplant. The device circulates blood through the donated heart, keeping it beating and giving doctors more time to perform a transplant.

A Patient Guide to Transplantation (PDF)

Read the Transplant Center's award-winning patient education guide, Transplantation: What Do I Need to Know?

¿Qué necesito saber? (PDF)

En español.

Heart Transplant Program

55 Fruit Street
Boston, MA 02114

Phone: 866-MGH-8910

Public Transportation Access: yes
Disabled Access: yes

Refer a patient to the Transplant Center

Request an appointment for your patient with one of our world-class transplant specialists.

Discover the Transplant Center patient experience

Our approach to patient care brings together a team of transplant specialists who create a personalized treatment plan for each patient.


U.S. News and World Report Best Hospitals 2015-2016

U.S. News & World Report ranks Mass General the #1 hospital in the nation. As part of a top-ranked hospital, MassGeneral Hospital for Children also ranks in three pediatric specialties.