As many as half of all men taking the antidepressant medication paroxetine (trade names Seroxat, Paxil) may have increased sperm DNA fragmentation — a predictor of compromised fertility. The study also found that the changes are reversible with normal levels of sperm returning after discontinuation of the drug.

Depression Medications May Reduce Male Fertility

Study Shows Abnormal Sperm DNA Fragmentation in Half of Men Taking an SSRI

11/Jun/2009

As many as half of all men taking the antidepressant medication paroxetine (trade names Seroxat, Paxil) may have increased sperm DNA fragmentation - a predictor of compromised fertility. The study - led by Cigdem Tanrikut, MD, who is now at Mass. General - also found that the changes are reversible with normal levels of sperm returning after discontinuation of the drug.

Link to full release from Weill Cornell Medical College.