Bo Rueda, PhD
Mark Philippe, MD, MHCM

Investigator, Vincent Center for Reproductive Biology
Gynecologist/Obstetrician, Massachusetts General Hospital

Brief Overview of Phillippe Lab Research

Dr. Mark Phillippe received his BS and MD degrees from Northwestern University in Chicago.  Subsequently, he did his residency in Obstetrics & Gynecology at the Boston Hospital for Women and subspecialty fellowship in Maternal-Fetal Medicine at the Brigham & Women’s Hospital in Boston.

Dr. Phillippe has held faculty appointments at the Harvard Medical School, the Massachusetts Institute of Technology, the University of Chicago (where he served as Director for the Maternal-Fetal Medicine Fellowship Program and Vice-Chair for Research) and the University of Vermont (where he served as the Ob/Gyn Department Chair for 11 years). 

The goal of Dr. Phillippe's previous NIH and other funded research has been to elucidate the mechanisms underlying preterm delivery occurring in the presence of intrauterine inflammation, infection and hemorrhage.

More recently, Dr. Phillippe's research has begun to address the pathophysiologic mechanisms responsible for the increased maternal morbidity, mortality and preterm delivery in the presence of severe influenza infection.

In collaboration with other investigators in the Vincent Center for Reproductive Biology, Dr. Phillippe’s ongoing research is utilizing in-vivo timed-pregnant animal models, inflammation-induced gene expression, innate immunity, TLR signaling, intracellular calcium imaging and in-vitro contraction studies to help elucidate the signaling mechanisms leading to the excessive, self-destructive influx of inflammatory cells into the lung during pregnancy, and to the stimulation of myometrial contractions that result in preterm delivery.

Other ongoing studies by Phillippe’s research group are utilizing cultured uterine smooth muscle cells to assess inflammation-induced gene expression, innate immunity, TLR signaling, and intracellular calcium signaling in an effort to elucidate the mechanisms underlying infection/inflammation associated preterm delivery.

In addition to his clinical and administrative activities, Dr. Phillippe has been engaged in laboratory research as a physician-scientist for more than 25 years.  Dr. Phillippe has published over 90 biomedical papers, reviews and book chapters, presented over 115 scientific abstracts and given over 50 invited research lecture presentations.

He has served on multiple scientific peer review committees for the National Institutes of Health, the March of Dimes Foundation and other funding agencies; and he has served as a member on the Advisory Council for the National Institute of Child Health and Human Development (NICHD).

Dr. Phillippe is a member of multiple national scientific and medical societies including the Society for Gynecologic Investigation, the Perinatal Research Society, the Society for Maternal-Fetal Medicine, the American Gynecologic and Obstetrical Society, the American College of Obstetrics & Gynecology, the American Society for Cell Biology, and the American College of Physician Executives.

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