The Vincent Center for Reproductive Biology

Ho-Joon Lee, Ph.D.

Research Fellow

Education and Training
Hanyang University, Korea, BS
Hanyang University, Korea, MS
Hanyang University, Korea, PhD
Sungkyungwan University/Samsung Cheil Medical Center, Korea, Postdoct

Positions and Honors
Positions and Employment:
1985-1990:    Researcher, Infertility Research Lab/IVF Center, Cheil General Hospital
1990-1994:    Director of Reproductive Medical Laboratory, Cheil General Hospital
1995-1997:    Chief & Principal Investigator, Cheil Research Institute, Sungkyunkwan 
                       University/Samsung Cheil Medical Center
1995-1997:    Chief, Division of Research, IVF Center, Department of Obstetrics & 
                       Gynecology, Sungkyunkwan University/Samsung Cheil Medical Center
1998-2003:     Assistant Professor, Department of Physiology, Eulji University/School 
                       of Medicine 
1998-2002:     Chief, Division of Eulji Central Institute, Eulji Medical Center
2003-present: Research Fellow, Vincent Center for Reproductive Biology/Massachusetts
                        General Hospital/Harvard Medical School

Professional Memberships:
American Society of Reproductive Medicine (ASRM)
American Society of Human Genetics (ASHG)
Korean Society of Physiology
Korean Society of Andrology
Korean Society of Endocrine Diruptors
Korean Society of Fertility and Sterility
Korean Society of Fertilization and Implantation

Honors and Awards
1996: Young Scientist Award, Vth World Congress on Endometriosis, 
          Yokohama, Japan
2000: 1st Prize Paper Award, 52nd Annual Congress of International Session
          of The Japan Society of Obs & Gyn, Tokushima, Japan
2002: Serono Prize Poster Award, American Society for Reprodutive Medicine, 
          Seattle Washington
    
Selected peer-reviewed publications

1) Son IP, JY Hong, YS Lee, YS Park, JH Jun, Lee HJ, IS Kang and Jun JY. Efficacy of microsurgical epididymal sperm aspiration (MESA) and intacytoplasmic sperm injection (ICSI) in obstructive azoospermia. J Assise Reprod Genetics 13(1):69~72, 1996.

2) Jun JH, CK Lim, YS Park, YS Lee, JT Seo, IP Son, Lee HJ, IS Kang. Efficacy of Intracytoplasmic Sperm Injection(ICSI) Treatment in the Immunological Infertile Patients. American J of Reproductive Immunology 37:310~314, 1997.

3) Lee HJ, HS Lee, GJ Song, HK Byun, JT Seo, JH Kim, YS Lee. Analysis of the azoospermia factor (AZF) gene on Y chromosome and expression pattern of DAZ gene in Korean infertile Men. Korean J Fertil Steril 24(1):57-65, 1997.

4) Lee DR, JE Lee, HS Yoon, Lee HJ, MK Kim, SI Roh. The supplementation of culture medium with protease improves the hatching rate of mouse embryos. Human Reproduction 12(11):2493~2498,1997.

5) Byun HK, HW Youm, MK Koong, IP Son, IS Kang, Lee HJ. Efficacy of coculture system in the patients with poor prognoses on human IVF-ET program. Korean J Fertil Steril 24(2):211-216, 1997.

6) Byun HK, Lee HJ. Effect of epidermal growth factor(EGF) and anti-EGF on early embryonic development in mice. Korean J Animal Reprod 21(1): 61-69, 1997.

7) Lee HJ, HS Lee, GJ Song, HK Byun, YH Cho, JH Kim, JT Seo, YS Lee. A Study on the patterns of expression of the DAZ and HSP genes in the testicular tissue of men with azoospermia. J of Genetic Medicine 1(1):51~56, 1997.

8) Youm HW, HK Byun, GJ Song, HK Kim, Lee HJ. Differential expression of glucose transporter gene in mouse early embryos. Korean J Fertil Steril 25(1):77-86, 1998.

9) Koong MK, Jun JH, Song IO, Lee HJ, Kang IS. A second look at the embryo toxicity of hydrosalpingeal fluid : An in-vitro assessment in murine model. Human Reproduction, 13(10);2852-2856, 1998.

10) Kim DH, MS Lee, HG Kang, SW Han, MK Kim, WI Park, HT Lee, KS Chung, Lee HJ. Use of Non-contact type diode laser on assisted hatching of mouse embryos. Korean J Fertil Steril 26(2):185-192, 1999.

11) Kim DH, HJ Chi, HG Kang, SW Han, HT Lee, KS Chung, Lee HJ. Effects of gonadotropins on in vitro growth and maturation of mouse preantral follicles. Korean J Animal Reprod 23(1):53-61, 1999.

12) Kim JY, KH Park, JY Kim, BS Lee, DJ Cho, CH Song, JW Kim, Lee HJ. Detection of Y mosaicism in blood and gonad of patients with gonadal dysgenesis. Korean J Fertil Steril 26(3):457-465, 1999.

13) Lee HJ, MK Kim, DS Ko, HG Kang, DH Kim. Expression of testis specific genes of male germ cells in pre-pubertal mouse using in vitro culture system. J Korean Androl 18(1):33-40, 2000.

14) Park CB, WI Park, DS Ko, Lee HJ. Expression of exon 5-deleted estrogen receptor mRNA in human uterine leiomyoma and myometrium. Korean J Obstet Gynecol 43(4):641-648, 2000.

15) Song GJ, HS Lee, YS Park, Lee HJ, YS Lee, JT Seo, IS Kang. Expression pattern of germ cell-specific genes in the testis of patients with nonobstructive azoospermia: usefulness as a molecular marker to predict the presence of testicular sperm. Fertil Steril 73(6):1104-1108, 2000.

16) Lee MS, JO Park, JH Jung, JS Park, HG Kang, DH Kim, Lee HJ. Influence of maternal age on embryo quality and the frequency of multiple pregnancy in IVF-ET program. Kor J Fertil Steril 27(3):261-265, 2000.

17) Lee HJ, MK Kim, HG Kang, DH Kim, SW Han, DS Ko. Effects of bisphenol and octylphenol on TM3 cell: expression of cytochrome P450scc and estrogen receptor a mRNA. Dev Reprod 4(2):215-203, 2000.

18) Kwon HC, WI Park, SY Kim, DW Park, MR Kim, SW Han, DW Kim, Lee HJ, SK Kim, DJ Cho. Establishment of three dimensional in-vitro culture system with human endometrial cells: Induction of differentiation by sex steroid hormone and characterization. Korean J Ob & Gyn 44(1):65-73, 2001.

19) Lee HJ, MK Kim, DS Ko, KS Kim, HG Kang, DH Kim. Effects of xenoestrogens on gene expression of cytochrome P450 genes in vitro cultured mice spermatogenic cells. Korean J Fertil Steril 28(2):131-140, 2001.

20) Kim DH, MK Kim, HC Lee, DS Ko, WI Park, HC Kwon, Lee HJ. Effect of partial laser assisted hatching on mouse embryos. Korean J Fertil Steril 28(2):147-153, 2001.

21) Park WI, HC Kwon, DH Kim, HK Kang, MK Kim, HC Lee, JH Jung, MS Lee, Lee HJ. The effect of GM-CSF supplementation in culture medium in the human IVF programs. Korean J Fertil Steril 28(2):161-167, 2001.

22) Shim SH, CH Lee, YJ Park, Lee HJ, WI Park, YH Cho. Two inv dup(15) chromosomes in a woman with repeated abortions. American J Med Genetics 104:303-306, 2001.

23) Lee JW, Park JH, Kim KS, Lee EJ, Kim MO, Kim SH, Jeong SW, Kim CW, Lee HJ, Kang KS, Chang KT, Hyun BH, Ryoo ZY. Vasopressin-SV40 T antigen expression in transgenic mice induces brain tumor and lymphoma. Biochem Biophys Res Commun. 21;302(4):785-92, 2003.

24) Lee MS, Hyun SH, Lee CK, Im KS, Hwang IT, Lee HJ. Impact of xenoestrogens on the growth of human endometrial epithelial cells in a primary culture system. Fertil Steril. 79(6):1464-5, 2003

25) Gye MC, Ohsako S, Lee HJ. Assessment of reproductive health risk of polychlorinated biphenyl by monitoring the expression of claudins and transepithelial electrical resistance in mouse Sertoli cell. J Microbiol Biotechnol 13(4): 495-500, 2003.

26) Cho KI, Lee JW, Kim KS, Lee EJ, Suh JG, Lee HJ, Kim HT, Hong SH, Chung WH, Chang KT, Hyun BH, Oh YS, Ryoo ZY. Fine mapping of the circling (cir) gene on the distal portion of mouse chromosome 9. Comp Med 53(6):642-648, 2003.