The Vincent Center for Reproductive Biology

Bo R. Rueda, Ph.D.


       
Associate Director, Vincent Center for Reproductive Biology, Massachusetts 
General Hospital


Education and Training
University of Nevada-Reno, BS, Animal Sciences
University of Nevada-Reno, MS, Reprod Physiol
University of Wyoming, PhD, Reprod Biol
University of Arizona-Tuscon, Postdoc, Mol Endo

Positions and Honors:
Positions and Employment:
1994:            Assistant Research Scientist, Dept. of Physiology, 
                    College of Medicine, University of Arizona, Tucson, AZ
1996-2000:    Assistant Professor, Dept. of Obstetrics & Gynecology, University 
                    of Kansas School of Medicine-Wichita; Wichita, KS
1996-2000:    Senior Scientist, Women's Research Institute, Wichita, KS
1997-2000:    Research Scientist, Dept. of Veterans Affairs Medical Center, Wichita, KS
1997-2000:    Adjunct Assistant Professor, Dept. of Biological Sciences, Wichita 
                   State University, KS
1998-2000:    Associate Graduate Faculty, Dept. of Graduate Studies, Wichita State
                    University, KS
2000-present: Associate Biologist, Vincent Obstetrics & Gynecology Service, 
                    Massachusetts General Hospital, Boston, MA
2000-2004:    Assistant Professor, Dept. of Obstetrics, Gynecology & Reproductive 
                    Biology, Harvard Medical School, Boston, MA
2001-present: Director, Clinical Fellows Research Program, Vincent Obstetrics & Gynecology 
                    Service, Massachusetts General Hospital, Boston, MA 
2002-present: Associate Director, Vincent Center for Reproductive Biology, Massachusetts
                    General Hospital, Boston, MA
2004-present: Associate Professor, Dept. of Obstetrics, Gynecology & Reproductive 
                    Biology, Harvard Medical School, Boston, MA

Professional Memberships:
1998-present: The Endocrine Society
1999-present: American Association for the Advancement of Science 2001-present: American Society for Reproductive Medicine
1994-present: Society of the Study of Reproduction
2003-present: Society for the Study of Reproduction & Fertility

 Honors:
1994:         Invited Speaker, VIth Ovarian Workshop, Serono Symposia (Ann Arbor)
1996:         Invited Speaker, International Symposium on Cell Death in Reproductive 
                 Physiology, Serono Symposia (Chicago). 
1998:         Invited Speaker, XIIth Ovarian Workshop, Serono Symposia (Houston)
1998:         Invited Speaker, Symposium on Apoptosis in Reproduction & Infertility,
                16th World Congress on Fertility & Sterility (San Francisco) 
1999-2001: Ad Hoc Reviewer USDA CSRE proposals; Animal Reproductive Efficiency
2002:         USDA CSR Panel member; Animal Reproductive Efficiency
2002:         Endocrinology Editorial Board
2002:         Reproductive Biology & Endocrinology, Assistant Editor
2003:         NCI/NIH PO1, Ad Hoc review panel member; NIH/NICHD REN

Selected peer-reviewed publications

1) Rueda BR, Tilly KI, Hansen TR, Hoyer PB, Tilly JL. Expression of superoxide dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence supporting a role for oxidative stress in luteolysis. Endocrine 1995; 3:227-232.

2) Rueda BR, Tilly KI, Botros IW, Jolly PD, Hansen TR, Hoyer PB, Tilly JL. Increased bax and interleukin-1b-converting enzyme messenger ribonucleic acid levels coincide with apoptosis in the bovine corpus luteum during structural regression. Biol Reprod 1997; 56:186-193.

3) Rueda BR, Hendry IR, Tilly JL, Hamernik, DL. Accumulation of caspase-3 mRNA and induction of caspase activity in the ovine corpus luteum following prostaglandin-F2a treatment in vivo. Biol Reprod 1999; 60:1087-1092.

4) Rueda BR, Hendry IR, Hendry III WJ, Stormshak F, Slayden OD, Davis JS. Decreased progesterone levels and receptor antagonists promote apoptotic cell death in bovine luteal cells. Biol Reprod 2000; 62:269-276.

5) Westfall SW, Hendry IR, Obholz K, Rueda BR, Davis JS. Survival of granulosa cells is mediated by a phosphatidylinositol 3-kinase (PI-3-kinase)-Akt signaling pathway. Endocrine 2000; 12:315-332.

6) Rueda BR, Hendry IR, Davis JS. Stress-induced mitogen activated protein kinase signaling in the corpus luteum. J Mol Cell Endo 2000; 164:59-67.

7) Suter J, Hendry IR, Ndjountche L, Obholz K, Pru KK, Davis JS, Rueda BR. Mediators of interferon g-initiated signaling in bovine luteal cells. Biol Reprod 2001; 64:1481-1486.

8) Matikainen T, Perez GI, Zheng TS, Kluzak TR, Rueda BR, Flavell RA, Tilly JL. Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary. Endocrinology 2001; 142:2468-2480.

9) Duska LR, Garrett A, Rueda BR, Haas J, Chang Y, Fuller AF. Endometrial cancer in women 40 years old or younger. Gyn Onc 2001; 83: 388-393.

10) Carambula SF, Matikainen T, Flavell RA, Goncalves PRB, Tilly JL, Rueda BR. Caspase-3 is a pivotal mediator of apoptosis during luteal regression of the corpus luteum. Endocrinology 2002; 143: 1495-1501.

11) Cavicchio VA, Pru JK, Davis BS, Davis JS, Rueda BR, Townson DH Secretion of monocyte chemoattractant protein-1 by endothelial cells of the bovine corpus luteum: regulation by cytokines but not prostaglandin F2a. Endocrinology 2002; 143:3582-3589.

12) Davis BR, Rueda BR. The corpus luteum: An ovarian structure with maternal instincts and suicidal tendencies. Front Biosci 2002; 7: D 1949-1978.

13) Pru JK, Hendry IR, Davis JS, Rueda BR. Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38. Endocrinology 2002; 143: 4350-4357.

14) Carambula SF, Matikainen T, Flavell RA, Goncalves PRB, Tilly JL, Rueda BR. Prostaglandin F2a– and FAS-activating antibody-induced regression of the ovarian corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice. Reprod Biol Endocrinol 2003; 1:15.

15) Pru JK, Lynch MP, Davis JS, Rueda BR, Signaling mechanisms in tumor necrosis factor a-induced death of microvascular endothelial cells of the corpus luteum. Reprod Biol Endocrinol 2003; 1:17.

16) Henkes LE, Davis JS, Rueda BR. Mutant mouse models and their contribution to our knowledge of ovulation and development, function and regression of the corpus luteum. Reprod Biol Endocrinol 2003; 1:87.

17) Dong Q, Kirley S, Rueda B, Zukerberg L, Oliva E. Loss of cables, a novel gene on chromosome 18q, in ovarian cancer. Mod Path 2003; 16:862-868.

18) Fanzo J, Lynch MP, Phee H, Hyer M, Cremesti A, Grassmé H, Norris JS, Coggeshall KM, Rueda BR, Pernis AB, Kolesnick R, Gulbins E. CD95 rapidly clusters in cells of diverse origins. Can Biol and Ther, 2003 2:392-395

19) Davis JS, Rueda BR, Spanel-Borowski K. Microvascular Endothelial Cells of the Corpus luteum. Reprod Biol Endocrinol 2003; 1:89.

20) Zukerberg LR, DeBernardo RL, Kirley SD, D'Apuzzo M, Lynch MP, Littell RD, Duska LR, Boring L, Rueda BR. Loss of Cables, a CDK regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. Can Res 2004; 648:202-208.

21) Moriyama T, Littell RD, Debernardo R, Oliva E, Lynch MP, Rueda BR, Duska LR. BAG-1 expression in normal and malignant endometrium. Gyn Onc 2004; 94(2):289-295.

22) Gonzalez RR, Rueda BR, Ramos MP, Littell RD, Glasser S, Leavis PC. Leptin induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interlukin 1 receptor signaling. Endocrinology 2004; 145(8):3850-3857.

Book Chapters
1) Rueda BR, Hamernik DL, Hoyer PB, Tilly JL. Potential regulators of physiological cell death in the corpus luteum. In: Cell Death in Reproductive Physiology Serono Symposia, Tilly JL, Strauss JF, Tenniswood M (eds), Springer-Verlag, New York, 1997; pp. 161-181.

2) Duska LR and Rueda BR. Primary hormonal therapy of endometrial cancer. In: Fuller, AF, Seiden MV, Young RC, Editors. Uterine Cancer. Hamilton, Ontario: BCD Atlas Series, 2004;I 144-155.

3) Tilly JL, Pru JK, Rueda BR. Apoptosis and follicular atresia. In The Ovary, 2nd Edition. Leung P and Adashi E (eds), Elsevier Science, 2004: pp. 321-352.