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Brian Goldberg |
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Graduate Student
Bouma/Tearney Team
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| In the mid-infrared (mid-IR), biological samples exhibit rapid fluctuations in refractive index occur at spectral locations that are highly specific for chemical composition. The existence of these fluctuations opens up the possibility of performing reflectance spectroscopy with molecular specificity. There has been little comprehensive investigation of tissue scattering in the mid-IR due to the high water absorption of tissue. Our preliminary modeling studies suggest that remitted light may be detected from a reasonable depth within human tissues at optical windows in the mid-IR. The goal of this project is to investigate the potential of mid-IR scattering for characterization of biological samples and tissues. Our first specific aim is to determine the complex refractive index of a variety of clinically relevant molecules over the mid-IR portion of the spectrum using FTIR absorption measurements. We will subsequently utilize these measurements to model infrared optical propagation within tissue. Our simulations will provide data that will aid in selecting appropriate wavelengths for investigation, constructing a practical device for measuring scattered mid-IR light, and developing algorithms for the inverse problem. This technology will be tested in phantoms to determine the accuracy and sensitivity of mid-IR scattering spectroscopy for determining molecular composition.
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| Contact |
Phone: 617-726-7842
Fax: 617-726-4103
Email: bdg@mit.edu |
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