Publications by Michael R. Hamblin, Ph.D.

2000

Del Governatore M, Hamblin MR, Piccinini EE, Ugolini G, Hasan T. Targeted photodestruction of human colon cancer cells using charged 17.1a chlorine6 immunoconjugates. Br J Cancer 2000; 82:56-64.

Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KL, Tanabe KK, Hasan T. Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorine6 immunoconjugate. Cancer Res 2000; 60:4200-4205.

Hamblin MR, Miller JL, Ortel B. Scavenger-receptor targeted photodynamic therapy. Photochem Photobiol 2000; 72:533-540.

Hamblin MR, Del Governatore M, Rizvi I, Hasan T. Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer. Br J Cancer 2000; 83:1544-1551.

Kodama T, Hamblin MR, Doukas AG. Cytoplasmic molecular delivery with shock waves: importance of impulse. Biophys J 2000; 79:1821-1832.

Molpus KL, Hamblin MR, Rizvi I, Hasan T. Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecol Oncol 2000; 76:397-404.

2001

Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV, Hasan T. Pegylation of a chlorine6 polymer conjugate increases tumor targeting of photosensitizer. Cancer Res 2001; 61:7155-7162.

Soukos NS, Hamblin MR, Keel S, Fabian RL, Deutsch TF, Hasan T. Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer In-vivo . Cancer Res 2001; 61:4490-4496.

2002

Hamblin MR, O'Donnell DA, Murthy N, Contag CH, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by In-vivo bioluminescence imaging. Photochem Photobiol 2002; 75(1):51-57.

Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, Hasan T. Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J Antimicrob Chemoth 2002; 49:941-951.

Hamblin MR, Miller JL, Rizvi I, Ortel B. Degree of substitution of chlorin(e6) conjugated to charged poly-L-lysine chains affects their cellular uptake, localization and phototoxicity towards macrophages and cancer cells. J X-ray Sci Tech, May 2002; 10:139-152

Hamblin MR. Covalent photosensitizer conjugates for targeted photodynamic therapy. Trends in Photochem Photobiol 2002; 9:1-24.

Kodama T, Doukas AG, Hamblin MR. Shock wave-mediated molecular delivery into cells. Biochem Biophys Acta 2002; 1542:186-194

2003

Hamblin MR, Miller JL, Rizvi I, Loew HG, Hasan T. Pegylation of charged polymer-photosensitizer conjugates: effects on photodynamic efficacy. Br J Cancer 2003; 89:937-943.

Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T. Optical monitoring and treatment of potentially lethal wound infections In-vivo . J Infect Dis 2003; 187:1717-1725.

Kodama T, Doukas AG, Hamblin MR. Delivery of ribosome-inactivating protein toxin into cancer cells with shock waves. Cancer Lett 2003; 189:69-75.

2004

Castaño AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part one - photosensitizers, photochemistry and cellular localization. Photodiag Photo Ther 2004;1:279-93.

Demidova TN, Hamblin MR. Macrophage-targeted photodynamic therapy. Int J Immunopathol Pharmacol 2004;17(2):117-26.

Demidova TN, Hamblin MR. Photodynamic therapy targeted to pathogens. Int J Immunopathol Pharmacol 2004;17(3):245-54.

Gad F, Zahra T, Hasan T, Hamblin MR. Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteria. Antimicrob Agents Chemother 2004;48(6):2173-8.

Gad F, Zahra T, Francis K, Hasan T, Hamblin MR. Targeted photodynamic therapy of established soft-tissue infections in mice. Photochem Photobiol Sci 2004;3(5):451-458.

Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004;3(5):436-50.

Khadem JJ, Martino M, Anatelli F, Dana MR, Hamblin MR. Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glue. Lasers Surg Med 2004;35(4):304-11.

Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, Gad F, Hamblin MR, Sastry KN, Ezekowitz RAB. Mannose-binding lectin-deficient mice are susceptible to infection with staphylococcus aureus. J Exp Med 2004;199(10):1379-90.

2005

Castaño AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two - cellular signaling, cell metabolism and modes of cell death. PPT 2005;2:1-23.

Castaño AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part three - Photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction. PPT 2005;2:91-106.

Demidova TN, Hamblin MR. Effect of cell-photosensitizer binding & cell density on microbial photoinactivation. Antimicrob Agents Chemother 2005;49(6):2329-35.

Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR. Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J Photochem Photobiol B 2005;81:15-25.

Demidova TN, Hamblin MR. Photodynamic inactivation of Bacillus spores, mediated by phenothiazinium dyes. Appl Environ Microb 2005;71(11):6918-25.

Ganz RA, Viveiros J, Ahmad A, Ahmadi A, Khalil A, Tolkoff MJ, Nishioka NS, Hamblin MR. Helicobacter pylori in patients can be killed by visible light. Laser Surg Med 2005;36(4):260-5.

Hamblin MR, Viveiros J, Yang C, Ahmadi A, Ganz RA, Tolkoff MJ. Heliobacter pylori accumulates photoactive porphyrins and is killed by visible light. Antimicrob Agents Chemother 2005;49(7):2822-7.

Lambrechts SA, Demidova TN, Aalders MC, Hasan T, Hamblin MR. Phtodynamic therapy for Staphylococcus aureus infected burn wounds in mice. Photochem Photobiol 2005;4:503-9.

Liu Q, Hamblin MR. Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation state. Int J Immunopath Pharmacol 2005;18:391-402.

Tegos GP, Demidova TN, Arcilla-Lopez D, Wharton T, Hariprased G, Hamblin MR. Cationic fullerenes are effective and selective antimicrobial photosensitizers. Chem Biol 2005;12:1127-35

2006

Anatelli F, Mroz P, Liu Q, Yang C, Castano AP, Swietlik E, Hamblin MR. Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection. Mol Pharm 2006;3(6):654-664.

Borbas KE, Mroz P, Hamblin MR, and Lindsey JS. Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility. Bioconj Chem, 2006, 17: 638-653

Burkatovskaya M, Tegos GP, Swietlik E, Demidova TN, P Castano A, Hamblin MR. Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. Biomaterials. 2006 Aug;27(22):4157-4164.

Castaño AP, Liu Q, and Hamblin MR. Green fluorescent protein expressing but not wild-type tumors in mice are cured by photodynamic therapy. Brit J Cancer, 2006, 94, 391-397.

Castaño AP, Mroz P, and Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer, 2006, 6: 535-545

Foley JW, Song X, Demidova TN, Jilal F, Hamblin MR. Synthesis and properties of benzo[a]phenoxazinium chalcogen analogs as novel broad-spectrum antimicrobial photosensitizers. J Med Chem. 2006, 49: 5291-5299.

Møller-Kristensen M, Shi L, Ip E, Gowda LD, Hamblin MR, Thiel S, Jensenius JC, Ezekowitz RA, Takahashi K. Deficiency of mannose-binding lectin greatly increases susceptibility to post-burn infection with Pseudomonas aeruginosa. J Immunol, 2006, 176(3):1769-1775.

Tawakol A, Castano AP, Anatelli F, Bashian G, Stern J, Zahra T, Gad F, Chirico S, Ahmadi A, Fischman AJ, Muller JE, Hamblin MR. Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorin(e6). J Biomed Optics, 2006, 11: 210-218

Tegos GP, Hamblin MR . Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps, Antimicrob Agents Chemother, 2006, 50: 196-203

Tegos GP, Anbe M, Yang C, Demidova TN, Satti M, Mroz P, Janjua S, Gad F and Hamblin MR. Protease stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother, 2006, 50: 1402-1410.

2007

Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR,
Davis RW, Tompkins RG, and Rahme LG. Involvement of skeletal muscle gene
regulatory network in susceptibility to wound infection following trauma.
PLoS ONE, 2007, 2:e1356-1365.

Castano AP, Dai T, Yaroslavsky I, Cohen R, Apruzzese AW, Smotrich MH, Hamblin MR. Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time. Lasers Surg Med. 2007, 39(6):543-550.

Demidova-Rice TN, Salomatina EV, Yaroslavsky AN, Herman IM, Hamblin MR, Low-level light stimulates excisional wound healing in mice, Lasers Surg Med, 2007, 39(9):706-715

Fuchs, BB, Tegos GP, Hamblin MR, and Mylonakis E. Susceptibility of Cryptococcus neoformans to photodynamic inactivation Is associated with cell wall integrity. Antimicrob Agents Chemother, 2007, 51(8):2929-36.

Garcez AS, Nunez SC, Lage-Marques JL, Hamblin MR, Ribeiro MS. Photonic
real-time monitoring of bacterial reduction in root canals by genetically
engineered bacteria after chemomechanical endodontic therapy. Braz Dent J.
2007;18(3):202-7.

Garcez, AS; Ribeiro MS, Tegos GP, Nunez SC, Jorge AO, Hamblin MR. Antimicrobial photodynamic therapy combined with conventional endodontic treatment to combat root canal infection. Lasers Surg Med 2007;39(1):59-66.

Moller-Kristensen M, Hamblin MR, Thiel S, Jensenius JC, Takahashi K.  Burn Injury reveals altered phenotype in Mannan-Binding lectin-deficient mice.  J Invest Dermatol, 2007, 127:1524-1531.

Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T and Hamblin MR. Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism. Free Radical Biol Med, 2007 Sep 1;43(5):711-9.

Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR, Photodynamic therapy with fullerenes, Photochem Photobiol Sci, 2007, 6, 1139 - 1149.

Tang HM, Hamblin MR, Yow, CM. A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens. J Infect Chemother. 2007;13(2):87-91.

2008

Burkatovskaya M, Castano AP, Demidova-Rice TN, Tegos GP, Hamblin MR. Effect
of chitosan acetate bandage on wound healing in infected and non-infected
wounds in mice. Wound Repair Regenerat, 2008, in press.

Castano AP, Mroz P, Wu MX, Hamblin MR. Photodynamic therapy plus low-dose
cyclophosphamide generates antitumor immunity in a mouse model. Proc Natl
Acad Sci USA, in press, 2008.

Dai T, Tegos GP, Rolz-Cruz G, Cumbie WE, Hamblin MR. Ultraviolet-C
Inactivation of Dermatophytes: Implications for Treatment of Onychomycosis,
Br J Dermatol, in press 2008.

Garcez, AS, Nunez SC, Hamblin MR, and Ribeiro MS. Antimicrobial effects of
photodynamic therapy on patients with necrotic pulps and periapical lesion.
J Endodont, 2008, 34:138-142.

Tawakol, A., Castano, A. P., Gad, F., Zahra, T., Bashian, G., Migrino, R. Q., Ahmadi, A., Stern, J., Anatelli, F., Chirico, S., Shirazi , A., Syed, S., Fischman, A. J., Muller, J. E., and Hamblin, MR. Intravascular detection of inflamed atherosclerotic plaques with a scavenger receptor-targeted fluorescent photosensitizer. Photochem Photobiol Sci, 2008, 7, 33-39.

WangXL, Wang HW, Hillemanns P, Hamblin MR. Distinctive features of foreskin
condylomata acuminata associated with diabetes mellitus. Arch Derm
Venereol, in press 2008.

Books

Mechanisms for Low-Light Therapy I, edited by Hamblin MR, Waynant RW,
Anders JJ, Proceedings of SPIE Vol. 6140 (SPIE, Bellingham, WA 2006).

Mechanisms for Low-Light Therapy II, edited by Hamblin MR, Waynant RW,
Anders JJ, Proceedings of SPIE Vol. 6428 (SPIE, Bellingham, WA 2007).

Mechanisms for Low-Light Therapy III, edited by Hamblin MR, Waynant RW,
Anders JJ, Proceedings of SPIE in press (SPIE, Bellingham, WA 2008).

Advances in Photodynamic Therapy: Basic, Translational and Clinical, edited
by Hamblin MR and Mroz P. Artech House, Inc, Norwood, MA: 2008 (in press).

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