Seok-Hyun (Andy) Yun, Ph.D.

Assistant Professor

Wellman Center for Photomedicine

Massachusetts General Hospital

Research Interests

My lab focuses on developing new optical technologies and applying them to solve biological questions and medical problems.  To realize this goal, we integrate our expertise in physics, photonics, and various engineering disciplines with biomedical needs and curiosities. Our research activities therefore include multidisciplinary collaboration particularly with biologists and clinicians.  Also we sometimes jointly pursue collaboration with industrial partners to enhance the practical impacts of research. Current research projects are as follows:

Technologies

•  Optical coherence tomography
•  In vivo confocal and multiphoton microscopy
•  Miniature mouse endomicroscopy
•  Brillouin biomechanical imaging
•  Adaptive light focusing in tissue
•  Novel bio-lasers
•  Fiber-optic sensing for medical and military applications.

Collaborative projects

•  Cellular and molecular studies (using mice models) of inflammatory bowel disease, colon cancer, chronic heart rejection, etc.
•  Diagnosis of cataract, presbyopia, and corneal problems.
•  Image-guided therapy

Selected Publications

1. S. H. Yun, “Mode locking of a wavelength-swept laser,” Optics Letters 30, 2660-2 (2005).
2. E. C. W. Lee, J. F. de Boer, M. Mujat, H. Lim, and S. H. Yun, “In vivo optical frequency domain imaging of human retina and choroid,” Optics Express 14, 4403-11 (2006).
3. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. Desjardins, R. Chan, M. Suter, J. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nature Medicine 12, 1429-33 (2006) - Link.
4. P. Kim, M. Puoris’haag, D. Cote, C. P. Lin, and S. H. Yun, “In vivo confocal and multiphoton microendoscopy,” J Biomedical Optics 13; 010501 (2008).
5. G. Scarcelli and S. H. Yun, “Confocal Brillouin microscopy for three-dimensional mechanical imaging,” Nature Photonics 2, 39-43 (2008) - Link.

Dr. Yun is also an affiliated faculty member of Harvard-MIT Health Sciences and Technology (HST) and a co-director of HST Summer Institute on Biomedical Optics.  If you are interested in Ph.D. or post-doctoral research opportunities, send an email to Dr. Yun with your CV at syun@hms.harvard.edu.