In-vivo Microscopy Cytometry and Spectroscopy

Advanced microscopy and spectroscopy in biological systems allows us to observe the composition and mechanisms of molecules, organelles, cells and tissues in their native states. Real time, in-vivo imaging down to the single molecule level promises to extend our insight into both normal and pathological activity within the human body. These technologies have the potential to significantly enhance information obtained for diagnosis of disease and for monitoring the effects of treatment therapies.

Katrin Kneipp
Enhanced local optical fields of gold- and silver nanostructures associated with surface plasmon resonances open exciting capabilities in spectroscopy. We are using this approach for exploring and developing new spectroscopic tools for molecular and chemical probing of biological structures and biomedically relevant molecules at the nanoscale and with single molecule sensitivity.

Charles Lin

Gary Tearney

 

Andy Yun
The development and application of novel in-vivo imaging techniques for basic and translational biological investigations. Interested technologies include real-time confocal and two-photon fluorescence imaging, nonlinear microscopy, miniature microendoscopy, microsurgery, and new methods.