Center for Applied Clinical Investigation Research Lab

Overview

The Center for Applied Clinical Investigation (CACI) in the Division of Oral and Maxillofacial Surgery and Dentistry at Massachusetts General Hospital was established in 2000 as both a research center and a center for training academic oral surgeons in clinical investigation. The center is dedicated to understanding the variables that contribute to manageable risks and complications and to guiding oral and maxillofacial surgeons to the best outcomes based on scientific evidence.

The clinical investigation model was developed as a research program designed to provide a clinical complement to basic science research across the oral and maxillofacial surgery domain. Literature worldwide is monitored and we work to initiate and support research in emerging and under-studied disciplines. The goal is to expand the literature to promote evidence-based clinical practice and improved outcomes in oral and maxillofacial surgery. Hypothesis-driven research questions are created rigorous, sound scientific studies are designed to contribute concrete findings and outcomes that promote evidence-based clinical practice.

Research Positions

The CACI Fellowship in Clinical Investigation is an opportunity for an oral and maxillofacial surgeons to work at Mass General with CACI mentors on a course of independent clinical research in a focused area. Fellows spend two years at Mass General and their research may be integrated with a related graduate study at Harvard School of Public Health or Harvard Medical School may be combined with a master’s in Public Health. Upon completion of the CACI Fellowship in Clinical Investigation, most fellows will have achieved the academic credentials necessary for a junior faculty appointment at an accredited hospital – or university-based oral and maxillofacial surgery program.

Learn about the fellowship

Publications

Selvi F, Faquin W, Michaelson M, August M. Atypical metastases of renal clear cell carcinoma to the head and neck. J Oral and Maxillofac Surg 2016 June;74(6):1286.

Chen S, Forman M, Sadow P, August M. Diagnostic accuracy of incisional biopsy in the oral cavity. J Oral and Maxillofac Surg 2016 May;74(5):959-64.

Misra S, Hass C, August M, Eberlin K. Delayed carotid dissection following lower lip revascularization in the setting of hyoid bone fracture. J Oral and Maxillofac Surg 2016 Jan;74(1):123-8.

Forman M, Sadow P, August M. The diagnostic accuracy of clinical diagnosis or oral lesions and patient specific risk factors that affect diagnosis. J Oral and Maxillofac Surg 2015 Oct;73(10): 1932-1937.

Geary S, Selvi F, Chuang SK, August M. Identifying dental panoramic radiographic features for screening osteoporosis in postmenopausal women. J Oral and Maxillofacial Surg 2015 Mar;44(3):395-399.

Coulter A, Dodson TB, Keith DA, Lahey EL, August M. Prognostic factors associated with arthroscopy success in the treatment of temporomandibular joint internal derangement. J Oral and Maxilofacial Surg 2013 (in preparation, abstract to be presented at AAOMS meeting 2013)

Kinard B, Chuang S, August M, Dodson T. How well do we manage the keratocystic odontogenic tumor? J Oral and Maxillofacial Surg 2012 Aug;71(8):1353-1358.

Guthrie D, Peacock ZS, Sadow P, Dodson TB, August M. Preoperative incisional and intraoperative frozen section biopsy techniques have comparable accuracy in the diagnosis of benign intraosseous jaw pathology. J Oral and Maxillofacial Surg 2012 Nov;70(11):2566-2572.

Lecornu MG, Chuang SK, Kaban LB, August M. Osteosarcoma of the jaws: Factors influencing prognosis. J Oral and Maxillofac Surg 2011;69:2368-2375.

Miksad RA, Lai KC, Dodson TB, Woo SB, Treister NS, Akinyemi O, Bihrie M, Maytai G, August M, Gazelle GS, Swan JS. Quality of life implications of bisphosphonate-associated osteonecrosis of the jaw. Oncologist 2011;16(1):121-132.

Abramson Z, Susarla S, August M, Troulis M, Kaban LB. Three-dimensional computed tomographic analysis of airway anatomy in patients with obstructive sleep apnea. J Oral Maxillofac Surg 2010;68:354-362.

Susarla S, August M, Dewsnup N, Faquin W, Kaban LB, Dodson TB. CD34 staining Density predicts giant cell tumor clinical behavior. J Oral and Maxillofac Surg 2009;67:951-956.

Dewsnup NC, Abulikemu M, Faquin WC, Kaban LB, August M. Immunohistochemical evaluation of giant cell tumors of jaws using CD34 density analysis. J Oral Maxillofac Surg 2008;66:928-933.

Beltran D, Faquin W, Gallagher G, August M. Selective immunohistochemical comparison of polymorphorphous low-grade adenocarcinoma and adenoid cystic carcinoma. J Oral Maxillofac Surg 2006;64:415-423.

Goldwaser B, Chuang SK, Kaban LB, August M. Risk factor assessment of the development of osteoradionecrosis of the jaws. J Oral Maxillofac Surg 2007;65:2311-2316.

Halpern LR, Dodson TB. A predictive model to identify women with injuries related to intimate partner violence. JADA 2006;137:604-9. Cover story.

Halpern LR, Perciaccetnte VJ, Hayes C, Susarla S, Dodson TB. A protocol diagnose intimate partner violence in the emergency department. J Trauma 2006;60(5):1101-5

Halpern LR, SusarlaS, Finkel M, Dodson TB. Injury location and screening questionnaires as markers for intimate partner violence. J Oral Maxillofac Surg 2005;1255-61

McDermott N, Chuang S-K, Woo VA, Dodson TB. Risk factors for complications after implant placement. Int J Oral Implantol 2003;18:848-55

Vehemente V, Chuang S-K, Muftu A, Daher S, Dodson TB. Risk factors for dental implant failure, J Oral Implantol 2002;28:74-81

Chuang, S-K, Tian L, Wei, L-J, Dodson TB. Kaplan-Meier analysis of dental implant survival: A strategy for estimating survival with clustered observations. J Dent Res 2001;81:2016-2020

August M, Glowacki J, Chung K, Chang Y. Influence of age and estrogen status on implant osseointegration. J Oral Maxillofac Surg; 59(11): 1285-1289, 2000.

TB Dodson, Sunk-Kiang Chuang. Frequency Estimates of BRON- Is it really zero? J Orral Maxillofac Syrg, July, 2008