Monday, January 12, 2015

Potentially Targetable Signaling Pathway Generates Slowly Proliferating, Chemo-resistant Cancer Cells

A signaling pathway responsible for the generation of slowly proliferating cancer cells, which are hard to eradicate with current treatments and thought to be a cause of subsequent disease relapse, has been reported in a Rapid Impact study published in Molecular Cancer Research, a journal of the American Association for Cancer Research.

“We have identified a new pathway in which well-studied signaling molecules string together to regulate cell proliferation,” said Sridhar Ramaswamy, MD, an associate professor of medicine at Massachusetts General Hospital Cancer Center and Harvard Medical School in Boston. “Since a number of these molecules are under intensive study as therapeutic targets for various cancer types, we are currently designing strategies to target this pathway in animal models in order to better clarify the potential clinical implications of these findings.

direct link to AACR release

Katie Marquedant, kmarquedant@partners.org, 617 726-0337

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