Explore This Laboratory

Overview

Emmanuel Buys, PhD
Associate Professor of Anesthesia, Associate Professor of Ophthalmology, Harvard Medical School
Associate Investigator, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Research Institute
Associate Member, Broad Institute
buyslab.mgh.harvard.edu

Description of Research

Our lab focuses on therapeutically targeting nitric oxide (NO) and cyclic guanosine monophosphate (GMP) signaling in a variety of disorders. Current research topics include:

  • Characterizing the role of NO-cGMP signaling in stroke, gastrointestinal motility, erectile function, renal function, brain and lung development, and cardiac dysfunction associated with systemic inflammation (in collaboration with investigators in Europe and the US). Furthermore, we are using sGC mutant mice to study the mechanisms underlying the ability of inhaled NO to attenuate injury associated with myocardial infarction and cardiac arrest
  • Elucidating the molecular mechanisms underlying the strain- and gender-specific hypertension associated with impaired NO-cGMP signaling. This project includes the characterization of renin and 20-hydroxyeicosatetraenoic acid (20-HETE) systems as blood-pressure modifying signaling mechanisms in a setting of impaired NO-cGMP signaling (e.g. in soluble guanylate cyclase (sGC)-deficient mice)
  • Elucidating the role of impaired NO-cGMP signaling in the development of primary open angle glaucoma. This project includes characterization of a new mouse model of glaucoma and identifying biomarkers and therapeutic targets in clinically relevant samples
  • Physiologic profiling of genetic variants in the genes encoding sGC and natriuretic peptides (NPs)
  • Using emerging genomic information to characterize NO signaling in the Weddell seal
  • Regulating cGMP signaling by microRNAs (miRs). This project aims to identify and therapeutically target miRs that regulate mRNAs encoding atrial natriuretic peptide (an activator of particulate guanylate cyclases), NO synthase, and soluble guanylate cyclase

Funding Information

  • R01-HL110378-01A1 (PI: Ichinose/Bloch) 04/01/12–03/31/17
  • R01 EY022746-01 (PI: Buys) 09/15/12–08/31/17
  • R01-HL11933-01A1 (PI: Newton/Cheh) 09/01/13–08/31/17
  • NSF 11-352 PLR (PI: Buys) 07/01/15–06/30/18

Selected Publications

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