The Department of Anesthesia, Critical Care and Pain Medicine at Massachusetts General Hospital conducts ground-breaking research focused on improving patient outcomes and patient care.
The Department of Anesthesia, Critical Care and Pain Medicine (DACCPM) at Massachusetts General Hospital is one of the leading research departments of anesthesia in the United States and in the world.
About Our Investigators
More than 80 investigators with faculty positions and more than 200 researchers in total are part of our research program. The department receives a large number of research grants from various federal agencies, foundations and industries.
Our program includes mentored investigators who are supported through a career-building research experience by being paired with a senior research faculty member. The mentor process is designed to enhance the junior investigator’s ability to attain advanced research skills and prepare them to independently compete for extramural funding.
Investigator Profiles & Search Tool
Many investigators are engaged in interdisciplinary and crossdisciplinary projects beyond the classical scientific boundaries of different fields. However, dynamic and innovative scientific environments need additional flexibility and tools for building new connections and collaborations.
To meet this need, we developed a hub of all investigators and their profiles with an integrated search tool. It comprises the 80+ investigators in the department with links to their personal profile pages, on which they include descriptions of their research projects and links to their publication lists and research websites. Jointly, these profiles capture the full spectrum of research interests in the department. The search tool displays all investigators when the search bar is empty. To see the list of investigators that match with specific research interests or centers, use the "Quick Search" list of frequent keywords or type your own into the search bar.
Investigators in the DACCPM conduct innovative research in the field of anesthesia aimed to advance patient safety during surgical procedures and improve the quality of life for patients. We have an impressive number of advanced investigators in our department focusing on a wide spectrum of research topics, including:
- Biomedical engineering
- Cardiovascular research
- Critical care
- Mechanisms of general anesthesia
- Pulmonary research
- Quality and safety
Research Centers and Units
The DACCPM at Mass General comprises centers and units that conduct innovative and collaborative research.
Research in the Anesthesia Center for Critical Care Research focuses on developing and testing new ways to make problematic procedures in the intensive care unit safer and more effective.
The Anesthesia Research Center (ARC) brings together essential research resources for department investigations and consists of clinical research coordinators/fellows, data scientists, statisticians and research administrators with extensive experience in clinical research. The ARC helps to facilitate all aspects of a research project, from study start-up to completion, and with services spanning Institutional Review Board assistance, subject recruitment, data collection/entry and statistical analysis. The ARC has also established a pathway that leverages the electronic health record so departmental investigators can get involved in observational research. By providing a robust research infrastructure, the ARC aims to support investigators throughout the research process in an effort to optimize study design and execution, regulatory oversight and statistical methods.
Research in the Beecher/Mallinckrodt Laboratories for Molecular Pharmacology Research focuses on elucidating the molecular mechanisms by which general anesthetics act to produce anesthesia and its side effects. Our work aims to create better treatments and ultimately a safer and more efficient practice of anesthesiology.
The Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic and cancer pain conditions. The center uses a multidisciplinary and mechanism-based research approach to clinical pain management together with basic science pain research.
The Clinical and Biochemical Pharmacology Laboratory focuses on elucidating the mechanisms of injury-related muscle wasting and exaggerated pain in order to find novel approaches to mitigate these acute- and long-term adverse outcomes of injury and associated inflammatory responses. The long-term goals of the laboratory are to improve the prognosis of patients with critical illness-induced complications, mitigate suffering—specifically for patients who are severely burned, injured or septic—and identify novel therapeutic maneuvers to rectify the deleterious consequences of injury and inflammation.
The Medical Device Plug-and-Play (MD PnP) Interoperability & Cybersecurity Program is a recognized leader in the development of the concepts and capabilities for integrated clinical environments of the future. Working with a geographically dispersed team of collaborators, the program has developed an open interoperable medical device clinical research platform, sharable databases, tools and applications. The goal is to enable a broader community of researchers and manufacturers to implement medical device interoperability aimed to improve patient safety and health care efficiency.
The Neuroscience Statistic Research Lab is a collaboration of investigators from Mass General, Harvard, MIT and Boston University that uses a systems neuroscience approach in studying how the state of general anesthesia is induced and maintained. The long-term goal of our research is to establish a neurophysiological definition of anesthesia; safer, site-specific anesthetic drugs, and to develop better neurophysiologically based methods for measuring depth of anesthesia.
The Pulmonary Imaging and Bioengineering Laboratories are a multidisciplinary, interdepartmental group of investigators who strive to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling, and bioengineering.
Our History of Innovation
The first successful public demonstration of the use of ether for surgical anesthesia was the start of many advances in the field led by those at Mass General. In this video, learn about our history of innovation in anesthesia.