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Protocol # 15-542

Status

Recruiting

Description

This research study is studying radiation therapy as a possible treatment for meningioma or tumor on the lining of the brain. The study drug or intervention involved in this research study is Intensity Modulated Proton Therapy (IMPT)

Condition

  • Meningioma
  • Brain Tumor

Interventions

  • Intensity Modulated Proton Therapy (IMPT)

Phase

N/A

Study Type

Interventional

Further Study Details

Primary Outcome:

  • Assess Safety and Utility of Increased Dose IMPT: Dose-limiting toxicity (DLT) using NCI CTC 4.0

Secondary Outcome:

  • The Absence of Progressive or Recurrent Disease
  • Overall Survival
  • Calculate Linear Energy Transfer Using Computer Simulations Based on the Treatment Plan

Enrollment

60

Study Start Date

February 2016

Eligibility

  • Gender:     All
  • Minimum age:     18 Years
  • Maximum age:     N/A
  • Healthy volunteers:     No

Sponsors

Massachusetts General Hospital

Source

Massachusetts General Hospital

Official title

A Phase I/II Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas

Clinicaltrials.gov Identifier

NCT02693990

     

Source: Clinicaltrials.gov. Through our founding membership in the Dana-Farber/Harvard Cancer Center, an NCI-designated Comprehensive Cancer Center, these clinical trials are conducted at the Massachusetts General Hospital Cancer Center and may be available at other partner institutions.