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Protocol # 17-733




This phase III trial studies how well radiation therapy with protons works compared with photons in treating patients with liver cancer. Radiation therapy, such as photon therapy, uses high energy x-rays to send the radiation inside the body to the tumor while proton therapy uses a beam of proton particles. Proton therapy can stop shortly after penetrating through the tumor and may cause less damage to the surrounding healthy organs and result in better survival in patients with liver cancer.


  • Unrectable or Locally Recurrent Hepatocellular Carcinoma


  • Proton Therapy (Radiation Therapy)
  • Photon Therapy (Radiation Therapy)


Phase 3

Study Type


Further Study Details

Primary Outcome:

  • Overall Survival (OS)

Secondary Outcome:

  • Progression-Free Survival (PFS)
  • Local Progression (LP)
  • Incidence of adverse events as assessed by Common Terminology Criteria for Adverse Events version 5
  • Fatigue as measured by the PROMIS fatigue short form version 1.0 8a
  • Correlation of Hepatocyte Growth Factor (HGF) biomarker with OS, PFS and fatigue
  • Quality Adjusted Survival (if primary endpoint is met)
  • Exploratory - Overall Quality of Life (QOL)



Study Start Date

June 22, 2017


  • Gender:     All
  • Minimum age:     18 Years
  • Maximum age:     N/A
  • Healthy volunteers:     No


NRG Oncology


NRG Oncology

Official title

A Phase III Randomized Trial of Protons Versus Photons for Hepatocellular Carcinoma Identifier



Source: Through our founding membership in the Dana-Farber/Harvard Cancer Center, an NCI-designated Comprehensive Cancer Center, these clinical trials are conducted at the Massachusetts General Hospital Cancer Center and may be available at other partner institutions.