• Mohamed Aburawi, MBBS

    Mohamed Aburawi, MBB

    Education:
    MBBS, Al Margeb University Faculty of Medicine, Libya, 2014

    Contact:
    Phone: 857-928-0727
    Contact by email

    Research:
    Using ex vivo machine perfusion systems, I'm working on assessing and potentially reviving discarded donor livers and kidneys that have been deemed unsuitable for transplantation. My work also focuses on stimulating ex-vivo liver graft regeneration using normothermic perfusion.


  • Aylin Acun, PhD

    Aylin Acun, PhD

    Education:
    PhD, Bioengineering Graduate Program, University of Notre Dame, 2018
    MS, Biotechnology, METU, 2013
    BS, Biological Sciences, METU, 2010

    Contact:
    Contact by email

    Research:
    My research at CEM focuses on the development of functional liver substitutes using donor livers that were rejected for transplantation. We aim to repurpose such livers through decellularizing them and subsequently repopulating them with primary hepatocytes or human induced pluripotent stem cells. In addition, I am interested in identifying the extracellular matrix factors that play role in liver function and regeneration through studying rat and human livers at different ages and disease conditions.


  • Berent Aldikacti, MD

    Berent Aldikacti, MD

    Education:
    MD, Yeditepe University, 2015

    Contact:
    Phone: 617-383-3838
    Contact by email

    Research:
    My main research goals include studying blood-based biomarkers, such as extracellular vesicles and circulating tumor cells, role in early detection and prognosis of Glioblastoma Multiforme patients, using microfluidic platforms and high-throughput imaging. Furthermore, I am using two and three-dimensional in vitro tumor models to understand their effects on the biogenesis of extracellular vesicles.


  • Beyza Bulutoglu, PhD

    Beyza Bulutoglu, PhD

    Education:
    PhD, Chemical Engineering, Columbia University, New York, 2017
    MS, Biomedical Engineering, Yale University, New Haven, 2011
    BS, Chemical Engineering, Bogazici University, Turkey, 2010

    Contact:
    Contact by email

    Research:
    During my masters studies, my research focused on the synthesis of theranostic nanoparticles for dual drug-delivery/imaging purposes. My doctoral thesis work concentrated on basic and applied aspects of protein engineering as well as molecular biology, focusing specifically on engineering different biomolecular interfaces for biotechnology applications, such as proteinaceous hydrogel formation. At CEM, I am using my background in protein and genetic engineering for medically oriented studies. My current research activities are focused on elucidating drug-drug interactions at the transcriptional level in hepatocytes and constructing recombinant bioactive peptides for tissue engineering purposes.


  • Luciana Da Silveira Cavalcante, PhD

    Luciana Da Silveira

    Education:
    Postdoc, Cryobiology, University of Alberta, Canada 2017-2018
    PhD, Biopreservation, University of Alberta, Canada, 2017
    MSc, Clinical Biochemistry, Federal University of Santa Catarina, Brazil, 2011
    BSc, Pharmacy and Laboratory Medicine, Federal University of Santa Catarina, Brazil, 2009

    Contact:

    Research:
    I am a pharmacist and medical laboratory technologist who specialized in biopreservation. My interests and expertise revolve around the area of preservation of clinically relevant cell types and cryobiology, I recently joined CEM/Mass General as a research fellow where I will develop novel methods for the handling and bio-stabilization of hearts for transplantation.


  • Reinier J. de Vries, MD

    Reinier J. de Vries

    Education:
    MD, (Cum laude), Medicine, University of Amsterdam, 2018
    BSc (Cum laude), Medicine, University of Amsterdam, 2014
    BSc (Cum laude), Mechanical Engineering, Technical University Delft, 2013

    Contact:
    Phone:617-515-3518
    Contact by email

    Research:
    As a research fellow with a combined background in medicine and engineering I focus on the development and translation of (bio)technological innovations in surgery. Considering the current donor organ shortage crisis, my research is focused on biopreservation for transplantation, ranging from cells to whole human organs. In particular, I am working on machine perfusion of liver and kidneys; high subzero liver preservation by supercooling and partial freezing; and isolation, slow freezing and vitrification of primary hepatocytes for their use in cell transplantation and bioartificial liver support systems.


  • Felix Ellett, PhD

    Felix Ellett, PhD

    Education:
    PhD, Medical Biology, the Walter & Eliza Hall Institute, 2011
    BS (Hons), the University of Melbourne, 2006

    Contact:
    Phone: 617-724-3209
    Contact by email

    Research:
    My research is centered on achieving a deeper understanding of the innate immune response during inflammation and infection, with a particular focus on sepsis. Using microfluidic technologies, I study alterations in immune cell activity that occur during sepsis. These assays can be used both as a diagnostic tool, and to provide insight into the fundamental biology that underpins sepsis development in at-risk patients.


  • A. Aslihan Gokaltun, PhD

    Education:
    PhD, Chemical Engineering, Hacettepe University, 2014
    MS, Chemical Engineering, Hacettepe University, 2009
    BS, Chemical Engineering, Hacettepe University, 2007

    Contact:
    Contact by email

    Research:
    I have a strong background that crosses polymer design, synthesis and characterization, materials science and surface engineering. In my past studies, I synthesized new, promising reactive polymeric microparticles and monoliths for the separation of various compounds in chromatographic applications with suitable chemistries, porosity properties and high specific surface areas. I’m also an expert in various chemical synthesis/surface functionalization methods for the prevention of the fouling or the non-specific adsorption of proteins and other biomacromolecules on surfaces. Non-specific protein adsorption is a significant challenge in biomaterials including biomicrofluidic devices. At CEM, I am using my background in chemical engineering and I’m designing and synthesizing novel polymeric materials to control bulk and surface properties of PDMS using scalable approaches to significant challenges in the manufacture of microfluidic devices with no added steps.


  • Shijie He, PhD

    Shijie He, PhD

    Education:
    PhD, Biomechanics, Beijing Institute of Technology, 2016
    BS, Engineering of Mechanics, Dalian University of Technology, 2010

    Contact:
    Contact by email

    Research:
    I am mainly interested in cell mechanics, i.e. the roles of physical/mechanical factors including forces, stiffness, geometries in cell migration, proliferation, and differentiation. Currently I am studying the effects of extracellular matrix on intestinal organoids which are derived from primary intestinal stem cell.


  • Alex Hopke, PhD

    Alex Hopke, PhD

    Education:
    PhD, Microbiology, The University of Maine, 2016
    BS, The University of Maine, 2010

    Contact:
    Phone: 978-758-0692
    Contact by email

    Research:
    Using a micro-spotting machine, I am examining the behaviors of immune cells during interactions with microbes, particularly the “neutrophil swarming” behavior. The role of neutrophil swarming during injury and infection in humans is poorly understood. Through our investigations we hope to both gain insight into the importance of swarming in humans and to apply this knowledge to develop ways to assist patients who may have swarming defects.


  • Haishui Huang, PhD

    Haishui Huang, PhD

    Education:
    PhD, Ohio State University, 2016

    Contact:
    Contact by email

    Research:
    My research areas are thermo-fluid stabilities of multiphase BioMEMS and biopreservation systems. Now I am working on deep-supercooling preservations for cells, tissues and organs.


  • Mehdi Jorfi, PhD

    Mehdi Jorfi, PhD

    Education:
    Postdoc, Massachusetts Institute of Technology, 2016
    PhD, Bioengineering, University of Fribourg, 2014

    Contact:
    Phone: 617-724-1053
    Contact by email

    Research:
    Neurological disorders represent a significant proportion of diseases burden and are of great medical importance, but the complexity of the human brain makes it difficult to closely model such diseases and to study experimentally. We address the lack of physiologically relevant human brain model by developing and validating a three-dimensional organotypic brain model to better recapitulate the in-vivo organ and the complex interactions between different cell types in the human brain. Such model offers a relevant and useful platform for the neurodegenerative disorders and diseases such as Alzheimer’s disease, and has the potential to further our understanding of the central nervous system pathology, and to accelerate the screening for novel therapeutic drugs.


  • Jae Jung Kim, PhD

    Jae Jung Kim, PhD

    Education:
    PhD, Chemical Engineering, Massachusetts Institute of Technology, 2017
    BS, Chemical & Biological Engineering, Seoul National University 2012

    Contact:
    Phone: 857-200-0458
    Email: Contact by email

    Research:
    My research focuses on the development of a ‘skin-on-a-chip’ device to study the neutrophil behavior in the skin. Using the controllability of microfluidic devices, this study will provide the fundamental knowledge of how neutrophil function in skin disease, such as cellulitis. Eventually, I will apply my knowledge towards the development of rapid diagnostic tool for skin disease.

  • Safak Mert, PhD

    Safak Mert, PhD

    Education:
    PhD, Ankara University, Biotechnology Institute, 2013
    MSc, Hacettepe University, Natural Sciences Institute, 2008
    BSc, Hacettepe University, Biology Department, 2003

    Contact:
    Contact by email

    Research:
    I’m currently working on identification of liver metabolic changes throughout the period of ischemia, reperfusion and subnormothermic machine perfusion (SNMP). Using these information, we hope to develop new perfusion techniques and improve both the quality of organ preservation and time of storage. Our final goal is reconditioning of ischemia injured organs and use them for transplantation


  • Baris R. Mutlu, PhD

    Baris R. Mutlu, PhD

    Education:
    PhD, Mechanical Engineering, University of Minnesota, 2016
    MS, Mechanical Engineering, Middle East Technical University / Turkey, 2010
    BS, Mechanical Engineering, Middle East Technical University / Turkey, 2007

    Contact:
    Phone: 617-643-4545
    Contact by email


  • Sinan Muldur, PhD

    Sinan Muldur, PhD

    Education:
    PhD, Nano-Biotechnology, University of Lyon I, France, 2016
    MS, Biomedical Engineering, King’s College of London, UK, 2011
    BS, Biomaterial and Tissue Engineering, Sheffield University, UK, 2010

    Contact:
    Contact by email

    Research:
    My research currently focuses on studying the effect of complement cascade activation and inhibition on human neutrophil behaviour (migration, swarming and phagocytosis) both in isolated neutrophils and in whole blood using microfluidic platforms. The precise characterization of neutrophil migration signatures to specific chemokines could have broad implications for our understanding of inflammatory responses hence the design of new therapeutic modulators.

    Furthermore, I am also working on the clinical validation study and optimization of our “Sepsis Chip”, a promising microfluidic device that permits early diagnosis and monitoring of septic patients from one drop of blood.


  • Jenny Nesbitt, PhD

    Jenny Nesbitt, PhD

    Education:
    PhD, Chemistry, Vanderbilt University 2016
    BS, Chemistry, Wake Forest University 2010

    Contact:
    Contact by email

    Research:
    My research at the CEM focuses on biopreservation as it relates to Global Health, specifically infectious diseases such as malaria. I work on the development of several cryopreservation strategies for the mosquito Anophelese gambiae and multiple stages of the malaria parasite, Plasmodium falciparum and Plasmodium vivax.


  • Ruben V. Oganesyan, MD

    Education:
    MD, Sechenov University, Moscow, 2017

    Contact:
    Contact by email

    LinkedIn Profile

    Research:
    My research is focused on tissue engineering of liver and skin derivatives. The liver project is aimed on vasculature restoration using endothelial cells following organ decellularization. The skin project is conducted in collaboration with Plastic Surgery Department of Mass General and aimed on improving cosmetological outcomes after breast cancer surgeries. Im also interested in mechanical engineering and developing custom perfusion bioreactors for our research projects at the CEM.


  • Joao Paulo Oliveira da Costa, PhD

    Oliveira da Costa Ph

    Education:
    PhD, Pathology, University of Sao Paulo, Brazil, 2014
    MS, University of Sao Paulo, Brazil, 2010
    DDS, Alfenas Federal University, Brazil, 2006

    Contact:
    Phone: 617-643-7213
    Contact by email
    Website

    Research:
    My research is focused in identifying molecular markers of progression in adult and pediatric solid tumors. We use circulating tumor cells and exosomes as models for blood-based biopsies to identify such markers, and better understand how tumors spread and metastasize. Using microfluidic technologies, we isolate tumor-specific exosomes and circulating tumor cells for downstream analysis such as single cell RNA sequencing, digital droplet PCR, label-free mass spectrometry and next generation sequencing.

    Furthermore, I still try to integrate Anatomic Pathology into state-of-art technologies, such as microfluidic isolation of tumor-derived cargo, and to single-cell analysis of tumor content. Maintaining tissue architecture as part of analysis is a powerful way of understanding more than cell signaling pathways, but also to understand how those different tumor cells interact in space. To achieve this goal I apply multispectral imaging and multiplexed immunohistochemistry to validate single cell RNA-Seq results, providing important clues on how tumor architecture helps shape the multiclonal nature of tumor cells, and how they interact with the microenvironment.


  • Derin Sevenler, PhD

    Derin Sevenler, PhD

    Education:
    PhD, Biomedical Engineering, Boston University, 2017
    BS, Mechanical & Aerospace Engineering, Cornell University, 2011

    Contact:
    Contact by email
    Website

    Research:
    I'm a biomedical engineer with a background in optics, automation and biomolecular assay development. I'm broadly interested in technology development for both biomedical research and applications in healthcare. Right now I'm working on several projects related to infectious disease and biopreservation. For example, one of my current projects involves researching new approaches to cryopreserve living cells, model organisms and pathogens so they can be studied in the lab or made available for therapeutic use.


  • Alfred Tamayo, PhD

    Alfred Tamayo, PhD

    Education:
    PhD, Molecular Medicine, Cell and Molecular Biology, Boston University School of Medicine, 2010
    BA, Biochemistry and Molecular Biology, Boston University, 2003

    Contact:
    Contact by email

    Research:
    My current research interest lies in integrative molecular biology and builds off my experience in studying protein toxin delivery and circadian clocks. I am designing DNA libraries that encode full-length biomolecules from whole genomes with the intent of discovering new transcriptional regulations, protein functions, and functional genetic mutations in a high throughput format. These libraries are built using a powerful technology developed in the Parekkadan lab that can capture and clone large DNA fragments in a massively parallel and multiplexed manner.


  • Xiao Wang, PhD

    Xiao Wang, PhD

    Education:
    PhD, University of Cincinnati, 2016
    BS, Huazhong University of Science and Technology, 2010

    Contact:
    Phone: 513-484-9685
    Contact by email
    Website: http://albertxiaowang.wixsite.com/xiaowang

    Research:
    My research is focusing on developing in vitro microfluidic assay to study the migration and interaction of immune cells in physiological and pathological conditions.