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Center for Engineering in Medicine
Meet the postdoctoral research fellows from the Center for Engineering in Medicine at Massachusetts General Hospital.
Education:MBBS, Al Margeb University Faculty of Medicine, Libya, 2014
Contact:Phone: 857-928-0727Contact by email
Research:Using ex vivo machine perfusion systems, I'm working on assessing and potentially reviving discarded donor livers and kidneys that have been deemed unsuitable for transplantation. My work also focuses on stimulating ex-vivo liver graft regeneration using normothermic perfusion.
Education:PhD, Bioengineering Graduate Program, University of Notre Dame, 2018 MS, Biotechnology, METU, 2013 BS, Biological Sciences, METU, 2010
Contact:Contact by email
Research:My research at CEM focuses on the development of functional liver substitutes using donor livers that were rejected for transplantation. We aim to repurpose such livers through decellularizing them and subsequently repopulating them with primary hepatocytes or human induced pluripotent stem cells. In addition, I am interested in identifying the extracellular matrix factors that play role in liver function and regeneration through studying rat and human livers at different ages and disease conditions.
Education:MD, Yeditepe University, 2015
Contact:Phone: 617-383-3838Contact by email
Research:My main research goals include studying blood-based biomarkers, such as extracellular vesicles and circulating tumor cells, role in early detection and prognosis of Glioblastoma Multiforme patients, using microfluidic platforms and high-throughput imaging. Furthermore, I am using two and three-dimensional in vitro tumor models to understand their effects on the biogenesis of extracellular vesicles.
Education:PhD, Chemical Engineering, Columbia University, New York, 2017 MS, Biomedical Engineering, Yale University, New Haven, 2011 BS, Chemical Engineering, Bogazici University, Turkey, 2010
Research: During my masters studies, my research focused on the synthesis of theranostic nanoparticles for dual drug-delivery/imaging purposes. My doctoral thesis work concentrated on basic and applied aspects of protein engineering as well as molecular biology, focusing specifically on engineering different biomolecular interfaces for biotechnology applications, such as proteinaceous hydrogel formation. At CEM, I am using my background in protein and genetic engineering for medically oriented studies. My current research activities are focused on elucidating drug-drug interactions at the transcriptional level in hepatocytes and constructing recombinant bioactive peptides for tissue engineering purposes.
Education:Postdoc, Cryobiology, University of Alberta, Canada 2017-2018 PhD, Biopreservation, University of Alberta, Canada, 2017 MSc, Clinical Biochemistry, Federal University of Santa Catarina, Brazil, 2011 BSc, Pharmacy and Laboratory Medicine, Federal University of Santa Catarina, Brazil, 2009
Research:I am a pharmacist and medical laboratory technologist who specialized in biopreservation. My interests and expertise revolve around the area of preservation of clinically relevant cell types and cryobiology, I recently joined CEM/Mass General as a research fellow where I will develop novel methods for the handling and bio-stabilization of hearts for transplantation.
Education:MD, (Cum laude), Medicine, University of Amsterdam, 2018 BSc (Cum laude), Medicine, University of Amsterdam, 2014 BSc (Cum laude), Mechanical Engineering, Technical University Delft, 2013
Contact:Phone:617-515-3518Contact by email
Research:As a research fellow with a combined background in medicine and engineering I focus on the development and translation of (bio)technological innovations in surgery. Considering the current donor organ shortage crisis, my research is focused on biopreservation for transplantation, ranging from cells to whole human organs. In particular, I am working on machine perfusion of liver and kidneys; high subzero liver preservation by supercooling and partial freezing; and isolation, slow freezing and vitrification of primary hepatocytes for their use in cell transplantation and bioartificial liver support systems.
Education:PhD, Medical Biology, the Walter & Eliza Hall Institute, 2011BS (Hons), the University of Melbourne, 2006
Contact:Phone: 617-724-3209Contact by email
Research:My research is centered on achieving a deeper understanding of the innate immune response during inflammation and infection, with a particular focus on sepsis. Using microfluidic technologies, I study alterations in immune cell activity that occur during sepsis. These assays can be used both as a diagnostic tool, and to provide insight into the fundamental biology that underpins sepsis development in at-risk patients.
Education:PhD, Chemical Engineering, Hacettepe University, 2014 MS, Chemical Engineering, Hacettepe University, 2009 BS, Chemical Engineering, Hacettepe University, 2007
Research:I have a strong background that crosses polymer design, synthesis and characterization, materials science and surface engineering. In my past studies, I synthesized new, promising reactive polymeric microparticles and monoliths for the separation of various compounds in chromatographic applications with suitable chemistries, porosity properties and high specific surface areas. I’m also an expert in various chemical synthesis/surface functionalization methods for the prevention of the fouling or the non-specific adsorption of proteins and other biomacromolecules on surfaces. Non-specific protein adsorption is a significant challenge in biomaterials including biomicrofluidic devices. At CEM, I am using my background in chemical engineering and I’m designing and synthesizing novel polymeric materials to control bulk and surface properties of PDMS using scalable approaches to significant challenges in the manufacture of microfluidic devices with no added steps.
Education:PhD, Biomechanics, Beijing Institute of Technology, 2016BS, Engineering of Mechanics, Dalian University of Technology, 2010
Research:I am mainly interested in cell mechanics, i.e. the roles of physical/mechanical factors including forces, stiffness, geometries in cell migration, proliferation, and differentiation. Currently I am studying the effects of extracellular matrix on intestinal organoids which are derived from primary intestinal stem cell.
Education:PhD, Microbiology, The University of Maine, 2016BS, The University of Maine, 2010
Contact:Phone: 978-758-0692Contact by email
Research:Using a micro-spotting machine, I am examining the behaviors of immune cells during interactions with microbes, particularly the “neutrophil swarming” behavior. The role of neutrophil swarming during injury and infection in humans is poorly understood. Through our investigations we hope to both gain insight into the importance of swarming in humans and to apply this knowledge to develop ways to assist patients who may have swarming defects.
Education:PhD, Ohio State University, 2016
Research:My research areas are thermo-fluid stabilities of multiphase BioMEMS and biopreservation systems. Now I am working on deep-supercooling preservations for cells, tissues and organs.
Education:Postdoc, Massachusetts Institute of Technology, 2016PhD, Bioengineering, University of Fribourg, 2014
Contact:Phone: 617-724-1053Contact by email
Research: Neurological disorders represent a significant proportion of diseases burden and are of great medical importance, but the complexity of the human brain makes it difficult to closely model such diseases and to study experimentally. We address the lack of physiologically relevant human brain model by developing and validating a three-dimensional organotypic brain model to better recapitulate the in-vivo organ and the complex interactions between different cell types in the human brain. Such model offers a relevant and useful platform for the neurodegenerative disorders and diseases such as Alzheimer’s disease, and has the potential to further our understanding of the central nervous system pathology, and to accelerate the screening for novel therapeutic drugs.
Education:PhD, Chemical Engineering, Massachusetts Institute of Technology, 2017 BS, Chemical & Biological Engineering, Seoul National University 2012
Contact: Phone: 857-200-0458 Email: Contact by email
Research:My research focuses on the development of a ‘skin-on-a-chip’ device to study the neutrophil behavior in the skin. Using the controllability of microfluidic devices, this study will provide the fundamental knowledge of how neutrophil function in skin disease, such as cellulitis. Eventually, I will apply my knowledge towards the development of rapid diagnostic tool for skin disease.
Education: PhD, Ankara University, Biotechnology Institute, 2013MSc, Hacettepe University, Natural Sciences Institute, 2008BSc, Hacettepe University, Biology Department, 2003
Research: I’m currently working on identification of liver metabolic changes throughout the period of ischemia, reperfusion and subnormothermic machine perfusion (SNMP). Using these information, we hope to develop new perfusion techniques and improve both the quality of organ preservation and time of storage. Our final goal is reconditioning of ischemia injured organs and use them for transplantation
Education:PhD, Mechanical Engineering, University of Minnesota, 2016MS, Mechanical Engineering, Middle East Technical University / Turkey, 2010BS, Mechanical Engineering, Middle East Technical University / Turkey, 2007
Contact:Phone: 617-643-4545Contact by email
Education: PhD, Nano-Biotechnology, University of Lyon I, France, 2016MS, Biomedical Engineering, King’s College of London, UK, 2011 BS, Biomaterial and Tissue Engineering, Sheffield University, UK, 2010
Research: My research currently focuses on studying the effect of complement cascade activation and inhibition on human neutrophil behaviour (migration, swarming and phagocytosis) both in isolated neutrophils and in whole blood using microfluidic platforms. The precise characterization of neutrophil migration signatures to specific chemokines could have broad implications for our understanding of inflammatory responses hence the design of new therapeutic modulators.
Furthermore, I am also working on the clinical validation study and optimization of our “Sepsis Chip”, a promising microfluidic device that permits early diagnosis and monitoring of septic patients from one drop of blood.
Education: PhD, Chemistry, Vanderbilt University 2016 BS, Chemistry, Wake Forest University 2010
Contact: Contact by email
Research: My research at the CEM focuses on biopreservation as it relates to Global Health, specifically infectious diseases such as malaria. I work on the development of several cryopreservation strategies for the mosquito Anophelese gambiae and multiple stages of the malaria parasite, Plasmodium falciparum and Plasmodium vivax.
Education: MD, Sechenov University, Moscow, 2017
Research: My research is focused on tissue engineering of liver and skin derivatives. The liver project is aimed on vasculature restoration using endothelial cells following organ decellularization. The skin project is conducted in collaboration with Plastic Surgery Department of Mass General and aimed on improving cosmetological outcomes after breast cancer surgeries. Im also interested in mechanical engineering and developing custom perfusion bioreactors for our research projects at the CEM.
Education: PhD, Pathology, University of Sao Paulo, Brazil, 2014 MS, University of Sao Paulo, Brazil, 2010 DDS, Alfenas Federal University, Brazil, 2006
Contact: Phone: 617-643-7213Contact by emailWebsite
Research: My research is focused in identifying molecular markers of progression in adult and pediatric solid tumors. We use circulating tumor cells and exosomes as models for blood-based biopsies to identify such markers, and better understand how tumors spread and metastasize. Using microfluidic technologies, we isolate tumor-specific exosomes and circulating tumor cells for downstream analysis such as single cell RNA sequencing, digital droplet PCR, label-free mass spectrometry and next generation sequencing.
Furthermore, I still try to integrate Anatomic Pathology into state-of-art technologies, such as microfluidic isolation of tumor-derived cargo, and to single-cell analysis of tumor content. Maintaining tissue architecture as part of analysis is a powerful way of understanding more than cell signaling pathways, but also to understand how those different tumor cells interact in space. To achieve this goal I apply multispectral imaging and multiplexed immunohistochemistry to validate single cell RNA-Seq results, providing important clues on how tumor architecture helps shape the multiclonal nature of tumor cells, and how they interact with the microenvironment.
Education:PhD, Biomedical Engineering, Boston University, 2017BS, Mechanical & Aerospace Engineering, Cornell University, 2011
Contact: Contact by emailWebsite
Research: I'm a biomedical engineer with a background in optics, automation and biomolecular assay development. I'm broadly interested in technology development for both biomedical research and applications in healthcare. Right now I'm working on several projects related to infectious disease and biopreservation. For example, one of my current projects involves researching new approaches to cryopreserve living cells, model organisms and pathogens so they can be studied in the lab or made available for therapeutic use.
Education:PhD, Molecular Medicine, Cell and Molecular Biology, Boston University School of Medicine, 2010BA, Biochemistry and Molecular Biology, Boston University, 2003
Research:My current research interest lies in integrative molecular biology and builds off my experience in studying protein toxin delivery and circadian clocks. I am designing DNA libraries that encode full-length biomolecules from whole genomes with the intent of discovering new transcriptional regulations, protein functions, and functional genetic mutations in a high throughput format. These libraries are built using a powerful technology developed in the Parekkadan lab that can capture and clone large DNA fragments in a massively parallel and multiplexed manner.
Education:PhD, University of Cincinnati, 2016BS, Huazhong University of Science and Technology, 2010
Contact:Phone: 513-484-9685Contact by emailWebsite: http://albertxiaowang.wixsite.com/xiaowang
Research: My research is focusing on developing in vitro microfluidic assay to study the migration and interaction of immune cells in physiological and pathological conditions.