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Center for Engineering in Medicine
Meet the postdoctoral research fellows from the Center for Engineering in Medicine at Massachusetts General Hospital.
Education:MBBS, Al Margeb University Faculty of Medicine, Libya, 2014
Contact:Phone: 857-928-0727Contact by email
Research:Using ex vivo machine perfusion systems, I'm working on assessing and potentially reviving discarded donor livers and kidneys that have been deemed unsuitable for transplantation. My work also focuses on stimulating ex-vivo liver graft regeneration using normothermic perfusion.
Education:MD, Yeditepe University, 2015
Contact:Phone: 617-383-3838Contact by email
Research:My main research goals include studying blood-based biomarkers, such as extracellular vesicles and circulating tumor cells, role in early detection and prognosis of Glioblastoma Multiforme patients, using microfluidic platforms and high-throughput imaging. Furthermore, I am using two and three-dimensional in vitro tumor models to understand their effects on the biogenesis of extracellular vesicles.
Education:PhD, Chemical Engineering, Columbia University, New York, 2017 MS, Biomedical Engineering, Yale University, New Haven, 2011 BS, Chemical Engineering, Bogazici University, Turkey, 2010
Contact:Contact by email
Research: During my masters studies, my research focused on the synthesis of theranostic nanoparticles for dual drug-delivery/imaging purposes. My doctoral thesis work concentrated on basic and applied aspects of protein engineering as well as molecular biology, focusing specifically on engineering different biomolecular interfaces for biotechnology applications, such as proteinaceous hydrogel formation. At CEM, I am using my background in protein and genetic engineering for medically oriented studies. My current research activities are focused on elucidating drug-drug interactions at the transcriptional level in hepatocytes and constructing recombinant bioactive peptides for tissue engineering purposes.
Education:PhD, Cell Biology, University of Nantes, France 2011MS, Bioengineering, Polytech Institute Clermont-Ferrand, France, 2006
Contact:Phone: 774-208-7142Contact by email
Research:I am a bioengineer with the goal of conducting a research program on wound healing process and tissue regeneration. I have a broad background in bioengineering as well as in cell biology, with specific training and expertise in vascular biology. As a postdoctoral fellow at Yale University, I laid the groundwork for the proposed research by developing an efficient nanoparticle-based therapy to promote angiogenesis in implantable 3D protein gel.
This engineered scaffold has been shown to accelerate and improve the formation of functional microvascular networks offering a promising strategy to overcome the lack of vascularization observed in patients in need of replacement tissues. I am currently developing new composite skin substitutes that incorporate nanoparticle-based delivery systems for wound healing therapies. I investigate various strategies for protecting bioactive molecules from harsh wound environment and controlling spatio-temporal release of bioactive peptides into matrix-based and cell-based skin substitutes.
Education:PhD, Medical Biology, the Walter & Eliza Hall Institute, 2011BS (Hons), the University of Melbourne, 2006
Contact:Phone: 617-724-3209Contact by email
Research:My research is centered on achieving a deeper understanding of the innate immune response during inflammation and infection, with a particular focus on sepsis. Using microfluidic technologies, I study alterations in immune cell activity that occur during sepsis. These assays can be used both as a diagnostic tool, and to provide insight into the fundamental biology that underpins sepsis development in at-risk patients.
Education:MD, University of Buenos Aires Medical School, 2012 PG-1 General Surgery, Johns Hopkins University, 2014 PG-2 General Surgery, Johns Hopkins University, 2015 PG-3 General Surgery, STEMC, Tufts University, 2016
Contact:Phone: 443-857-1115Contact by email
Research: I work in Dr. Markmann’s lab and my focus is on Ex-Vivo Organ Perfusion. We perform human kidney and liver perfusions at hypothermic, sub-normothermic and normothermic temperatures using different perfusates such as blood, synthetic oxygen carriers and enriched media to foster organ preservation, energy stores recovery, repair, and assessment of discarded grafts. Our goal is to decrease the enlarging disparity gap between donors and recipients by giving a more efficient use of marginal grafts trying to target those organs that are currently being discarded. We are in the process of receiving approval to start clinical trials and move these technologies into a clinical phase.
Education:PhD, Microbiology, The University of Maine, 2016BS, The University of Maine, 2010
Contact:Phone: 978-758-0692Contact by email
Research:Using a micro-spotting machine, I am examining the behaviors of immune cells during interactions with microbes, particularly the “neutrophil swarming” behavior. The role of neutrophil swarming during injury and infection in humans is poorly understood. Through our investigations we hope to both gain insight into the importance of swarming in humans and to apply this knowledge to develop ways to assist patients who may have swarming defects.
Education:PhD, Wuhan University, 2012BS, Central China Normal University, 2006
Contact:Phone: 857-600-1207Contact by email
Research:I’m interested in applying molecular biology, cell biology and bioengineering techniques to test novel therapies approach and address pressing biological problems in the medical field, such as tissue engineering, gene therapy and stem cell therapy. My current project focus on developing a novel gene-activated matrix (GAM) and genetically modified MSCs for tissue regeneration, including wound healing, spinal cord injury, and chondrogenesis.
Education:PhD, Bioengineering, University of Pittsburgh, 2013BS, Biomedical Engineering, Florida International University, 2006Contact:Phone: 617-371-4426Contact by email
Research:My research is focused in the development of tissue engineering-based artificial livers using decellularized liver matrix. Specifically, I am investigating cell-extracellular matrix (ECM) interactions in hepatic differentiation of human pluripotent stem cells, and developing approaches for recellularization of liver scaffolds using pluripotent stem cell derived cells. In addition, we are developing strategies for reendothelialization of decellularized liver scaffolds in order to achieve hemocompatibility in artificial liver grafts.
Furthermore, I am working in the design of pre-vascularized skin grafts with controlled capillary network geometry that will promote graft integration for the treatment of treatment for burn-related injuries.
Education:Postdoc, Massachusetts Institute of Technology, 2016PhD, Bioengineering, University of Fribourg, 2014
Contact:Phone: 617-724-1053Contact by email
Research: Neurological disorders represent a significant proportion of diseases burden and are of great medical importance, but the complexity of the human brain makes it difficult to closely model such diseases and to study experimentally. We address the lack of physiologically relevant human brain model by developing and validating a three-dimensional organotypic brain model to better recapitulate the in-vivo organ and the complex interactions between different cell types in the human brain. Such model offers a relevant and useful platform for the neurodegenerative disorders and diseases such as Alzheimer’s disease, and has the potential to further our understanding of the central nervous system pathology, and to accelerate the screening for novel therapeutic drugs.
Education:PhD, Massachusetts Institute of Technology, 2015MS, CEP, Massachusetts Institute of Technology, 2013BS, University of California, Berkeley, 2009Contact:Contact by email
Research:My research is focused on the development of point-of-care diagnostic tools for tuberculosis. We are working to apply microfluidic technologies to the rapid isolation of Mycobacterium Tuberculosis from blood without a reliance on specific biomarkers.
Education:PhD, Mechanical Engineering and Mechanics, Drexel University, 2015MS, Chemical Engineering, Seoul National University, 2004BS, Chemical Engineering, Korea University, 2001
Contact:Phone: 267-648-0385Contact by email
Research: My research interests lie at the intersection between microfabrication/microfluidics and biotechnology/bioengineering including bio-inspired engineering organ models, healthcare diagnostic devices, biomechanics and biosensors. Specifically, I am studying the development of novel microfluidic platforms for actively controlled in-vitro liver zonation. The developed liver model would be used for liver zonation study, disease research, and drug screening applications.
Education:PhD, Chemical Engineering, Massachusetts Institute of Technology, 2017 BS, Chemical & Biological Engineering, Seoul National University 2012
Contact: Phone: 857-200-0458 Email: Contact by email
Research:My research focuses on the development of a ‘skin-on-a-chip’ device to study the neutrophil behavior in the skin. Using the controllability of microfluidic devices, this study will provide the fundamental knowledge of how neutrophil function in skin disease, such as cellulitis. Eventually, I will apply my knowledge towards the development of rapid diagnostic tool for skin disease.
Education:BS, University of California, San Diego, Bioengineering, 2009PhD, Massachusetts Institute of Technology, Medical Engineering and Medical Physics
Contact: Contact by email
Research:My current research lies at the intersection of bioprocess engineering and cellular therapies in the Parekkadan lab. We are focusing on areas of: ex vivo engineered bioreactors towards improved control over therapeutic cell:cell interaction and efficient technologies to address scalable biomanufacturing pain points.
Education: PhD, Ankara University, Biotechnology Institute, 2013MSc, Hacettepe University, Natural Sciences Institute, 2008BSc, Hacettepe University, Biology Department, 2003
Research: I’m currently working on identification of liver metabolic changes throughout the period of ischemia, reperfusion and subnormothermic machine perfusion (SNMP). Using these information, we hope to develop new perfusion techniques and improve both the quality of organ preservation and time of storage. Our final goal is reconditioning of ischemia injured organs and use them for transplantation
Education:PhD, Mechanical Engineering, University of Minnesota, 2016MS, Mechanical Engineering, Middle East Technical University / Turkey, 2010BS, Mechanical Engineering, Middle East Technical University / Turkey, 2007
Contact:Phone: 617-643-4545Contact by email
Education: PhD, Nano-Biotechnology, University of Lyon I, France, 2016MS, Biomedical Engineering, King’s College of London, UK, 2011 BS, Biomaterial and Tissue Engineering, Sheffield University, UK, 2010
Research: My research currently focuses on studying the effect of complement cascade activation and inhibition on human neutrophil behaviour (migration, swarming and phagocytosis) both in isolated neutrophils and in whole blood using microfluidic platforms. The precise characterization of neutrophil migration signatures to specific chemokines could have broad implications for our understanding of inflammatory responses hence the design of new therapeutic modulators.
Furthermore, I am also working on the clinical validation study and optimization of our “Sepsis Chip”, a promising microfluidic device that permits early diagnosis and monitoring of septic patients from one drop of blood.
Education: PhD, Chemistry, Vanderbilt University 2016 BS, Chemistry, Wake Forest University 2010
Research: My research at the CEM focuses on biopreservation as it relates to Global Health, specifically infectious diseases such as malaria. I work on the development of several cryopreservation strategies for the mosquito Anophelese gambiae and multiple stages of the malaria parasite, Plasmodium falciparum and Plasmodium vivax.
Education: PhD, Pathology, University of Sao Paulo, Brazil, 2014 MS, University of Sao Paulo, Brazil, 2010 DDS, Alfenas Federal University, Brazil, 2006
Contact: Phone: 617-643-7213Contact by emailWebsite
Research: My research is focused in identifying molecular markers of progression in adult and pediatric solid tumors. We use circulating tumor cells and exosomes as models for blood-based biopsies to identify such markers, and better understand how tumors spread and metastasize. Using microfluidic technologies, we isolate tumor-specific exosomes and circulating tumor cells for downstream analysis such as single cell RNA sequencing, digital droplet PCR, label-free mass spectrometry and next generation sequencing.
Furthermore, I still try to integrate Anatomic Pathology into state-of-art technologies, such as microfluidic isolation of tumor-derived cargo, and to single-cell analysis of tumor content. Maintaining tissue architecture as part of analysis is a powerful way of understanding more than cell signaling pathways, but also to understand how those different tumor cells interact in space. To achieve this goal I apply multispectral imaging and multiplexed immunohistochemistry to validate single cell RNA-Seq results, providing important clues on how tumor architecture helps shape the multiclonal nature of tumor cells, and how they interact with the microenvironment.
Education:PhD, Physics, Bio-Physics, North Caroline State University, 2015MSc, Physics, Gravity and Cosmology, University of Tehran, 2011BSc, Physics, Solid State, University of Mazandaran, 2008
Contact:Phone: 617-724-5336Contact by email
Research:I am working on the interactions between Neutrophil Extracellular Traps (NETs) with whole blood in microfluidic systems. The gold of my research is to evaluate the utility of a novel biomarker in the context of septic shock in patients. Since septic shock is the most common cause of death in intensive care units, hopefully we can identify those patients at the early stage of disease with our new biomarker.
Education:PhD, Molecular Medicine, Cell and Molecular Biology, Boston University School of Medicine, 2010BA, Biochemistry and Molecular Biology, Boston University, 2003
Research:My current research interest lies in integrative molecular biology and builds off my experience in studying protein toxin delivery and circadian clocks. I am designing DNA libraries that encode full-length biomolecules from whole genomes with the intent of discovering new transcriptional regulations, protein functions, and functional genetic mutations in a high throughput format. These libraries are built using a powerful technology developed in the Parekkadan lab that can capture and clone large DNA fragments in a massively parallel and multiplexed manner.
Education:PhD, University of Cincinnati, 2016BS, Huazhong University of Science and Technology, 2010
Contact:Phone: 513-484-9685Contact by emailWebsite: http://albertxiaowang.wixsite.com/xiaowang
Research: My research is focusing on developing in vitro microfluidic assay to study the migration and interaction of immune cells in physiological and pathological conditions.
Education:PhD, Mechanical Engineering, Dailan University of Technology, 2012BS, Qingdao Technological University, 2007
Research:My research focuses on the biophysics and thermodynamics in biopreservation of living cells, tissues, and organs. One of the projects I am working on is to develop robust methods to cryopreserve Plasmodium sporozoites, the mosquito-stage malaria parasite, which will enable the global dissemination of Plasmodium sporozoites to researchers and eliminate the necessity of transporting live mosquitoes. I am also working on an organ-banking project aimed at preserving human organs over an extended period of time at a high subzero temperature between -4 and -20 °C.
Education:PhD, Stomatology, Zhejiang University, 2008Joint PhD program, Medical College of Georgia, 2007MD, DDS, Stomatology, Anhui Medical University, 2003
Contact:Phone: 617-372-4559Contact by email
Research: Research area is focus on the MSCs promote the regeneration of cartilage. Our long-term goal is to combine engineered biomaterials and stem cell based therapies to treat osteoarthritis (OA). We are trying to develop intra-articular, injectable, disease-modifying therapies that offer long-term relief from inflammation, and enhance cartilage regeneration.
Education:PhD, Biomedical Engineering, The University of Iowa, 2015MS, Biomedical Engineering, The University of Iowa, 2012MD, Nantong University College of Medicine, 2010
Contact:Address: 51 Blossom St., Boston, MA 02114Phone: 319-512-1717Fax: 617-573-9471Contact by email
Research:Dr. Yu`s research interest is primarily in the area of tissue engineering and in vitro 3D tissue/organ model for drug testing and disease modeling. He specifically focuses on developing gene-activated matrix (GAM) for in situ articular cartilage regeneration, and establishing cellular therapy techniques for osteoarthritis treatment by engineered mesenchymal stromal cells (MSCs). He also aims at developing in vitro model of osteoarthritis using Synthetic Biology and 3D Bio-printing.