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Center for Engineering in Medicine
A listing of research engineers and technicians, as well as other technical support staff, for the Center for Engineering in Medicine at Massachusetts General Hospital.
Research Associate, Cell Resource Core (CRC)Research Technician, Center for Engineering in Medicine (CEM)
Education:BS, Biochemistry, Minor in Biomedical EngineeringUniversity of Rochester, 2016
Contact:Contact by email
As a part of the organ reengineering team, I'm currently involved in animal surgery to isolate highly viable rat hepatocytes for use by lab members and hospital researchers. Additionally, I perform rodent liver harvests for projects such as liver recellularization/decellularization. I am also responsible for distribution and monitoring of controlled substances for the CEM. As a member of the CRC, I routinely perform human hepatocyte isolations and cryopreservation. My research area focuses on prolonging the time transplantable human organs and tissues remain alive ex vivo via perfusion techniques and supercooling methods. My goals consist of creating and developing life-saving technologies in the field of transplant surgery.
Education:MSc Biology, University of Massachusetts Boston, 2016
Studying the potential of various cryopreservation techniques for improving organ storage prior to transplantation, as well as the biology of organ storage.
Education:MS, Villanova UniversityBSc, Shahid Beheshti University
I started in Dr Irimia’s lab by volunteering to establish bacterial research to an interduce interface of bacteria and white blood cells in microfluidic devices. I am working on the effect of different antibiotics on neutrophils recruitments against Staphylococcus aureus. I am also involved in several projects that are in collaboration with people outside our lab including Forsyth Institute. We are trying to replicate in vitro of the human oral microbiome in a microfluidic device and imaging the interaction of individual taxa that comprise the oral microbial community.
Education:BS, Santa Clara University, 2017
As part of the BioMEMS Resource Center, I microfabricate, test, and analyze novel microfluidic devices for ultra high-throughput blood cell sorting. I also focus on the development of nanofluidic devices for size-based nanoparticle sorting.
In another aspect of my research, I isolate, expand, and characterize circulating tumor cells (CTCs) from blood-based liquid biopsies. I maintain a variety of cell lines to optimize the growth conditions for CTCs, as well as to provide cells for other lab members’ experiments.
Education:BS in Biological Sciences and BS in Biochemistry, Virginia Tech, 2016
Research: I am involved with a clinical study with ER patients that uses microfluidics as a diagnostic tool for early detection of sepsis using a drop of whole blood. I look at the interactions between antibiotic treated neutrophils and S. aureus, which have led to clinical studies taking skin biopsies and blood samples from patients with staph infections. This will hopefully lead to future developments of diagnostic platforms for better diagnosing diseases like cellulitis.
Lastly, I’m working at the forefront of the Dicty World Race where laboratories from around the world send in genetically engineered dictyostelium discoideum cells, other amoebas and mammalian leukocytes to race against neutrophils, the ultimate chemotaxic cell.
Associate Product Manager, Cell Resource CoreResearch Technician, Center for Engineering in Medicine
Education:BS, College of Biological Sciences, University of Minnesota-Twin Cities, 2016
Contact:Phone: 617-722-3000Contact by email
Research: I am part of the Cell Resource Core (CRC) and the organ reengineering team. I perform rodent and human hepatocyte isolations, to consistently provide highly viable primary cells for researchers. I also conduct rodent liver harvests and custom isolations upon request. I am involved in a hepatocyte cryopreservation project and an extended ex-vivo kidney perfusion project, as my research interests lie in rescuing discarded organs and maximizing donor organ viability.
Education:BSc Biochemistry & Genetics, University of Minnesota – Twin Cities, 2017
Research: At the CEM I am involved in two major research projects. First, the elucidation of drug-drug interactions at the transcriptional level, where we transfect primary hepatocytes and different hepatic cell lines, with reporter plasmids under the regulation of drug metabolizing pathways. My second project relies on the development of liver-on-a-chip disease models, where we culture hepatocytes in microfluidic devices to mimic, optimize and test various in vitro disease states, currently NAFLD and NASH. Both studies involve several molecular biology techniques including genetic cloning, quantitative PCR and other methods such as various biochemical assays and fluorescent and confocal microscopy.
Education:BSc Biotechnology (Bioinformatics Specification), Rutgers University New Brunswick
Research: I am a research technician involved in molecular biology and cell engineering efforts to develop genetic constructs and stable cell lines which culminates in a study on stem cell therapeutics. Additionally, I combine molecular biology and bioinformatics tools to optimize long adaptor single stranded oligonucleotides (LASSO), a robust and high throughput molecular biology tool pioneered by previous researchers in the Parekkadan Lab demonstrated to capture kilobase long genomic sequences in a multiplexed manner. My passion lies in integrative molecular biology and bioinformatics research with discovery and translational applications in mind.
Education:BS, Biomedical Engineering, University of Connecticut, 2017
I am currently working on isolating circulating tumor cells (CTCs) and circulating tumor cell clusters from whole blood samples. These cells, and more prominently cell clusters, can give important information on the diagnosed cancer. Using various microfluidic technologies, we are working to develop an optimum chip to isolate these cells, for further research, without damaging them.
Education:MS, RWTH-Aachen University, Germany, 2014Diplom, Luebeck University of Applied Sciences, Germany, 2011BS, East China University of Science and Technology, China, 2011
Contact:Phone: 857-540-8703Contact by email
Using whole-liver engineering technique, I'm attempting to reconstruct functional artificial livers with intact vascular structure and biliary tree via recellularizing decellularized liver matrix. This way we hope to improve the quality of marginal donor livers to solve the transplantable liver shortage crisis.