About David Sweetser, MD, PhD

Dr. Sweetser completed his MD/PhD at Wash. Univ Sch of Med in St. Louis, and Pediatric Residency training at St. Louis Children's Hosp. He did his Medical Genetics Fellowship training at the Wash. Univ Sch of Med in St. Louis and the Univ of Wash in Seattle along with a Biochemical Genetics Fellowship. He subsequently completed a Fellowship in Pediatric Hematology/Oncology at the Univ of Wash. in Seattle.  Since 2003 Dr. Sweetser has been at Massachusetts General Hospital seeing patients in Ped. Hem/Onc as well as Medical Genetics and Metabolism and runs a research lab in leukemia and medical genetics. Dr. Sweetser is Chief of the Division of Medical Genetics and Metabolism. Under his leadership the Genetics Program has markedly expanded more than doubling the number of patient visits with new specialty clinics in Turner Syndrome, Hereditary Hemorrhagic Telangiectasia, CHARGE syndrome, a multidisciplinary Sensorineural Hearing Loss Clinic at the MEEI, an Autism Genetics Clinic at the Lurie Center, Pitt Hopkins Syndrome, Pediatric Cancer Predisposition Clinic, as well as a world renown Down Syndrome clinic. Dr. Sweetser has been a leader in the application of  whole exome sequencing to clinical diagnostics. Dr. Sweetser is the MGH site director for the NIH sponsored Undiagnosed Diseases Network linking 11 medical centers around the country to accelerate discovery and innovation in the way we diagnose and treat patients with previously undiagnosed diseases.

Clinical Interests:



Mass General/North Shore Center for Outpatient Care
102-104 Endicott St.
Danvers, MA 01923
Phone: 978-882-6100

Mass General for Children: Pediatric Hematology & Oncology
55 Fruit St.
Yawkey Center for Outpatient Care
Suite 8B
Boston, MA 02114
Phone: 617-726-2737

Mass General for Children: Genetics Program
55 Fruit St.
Suite 6C
Boston, MA 02114
Phone: 617-726-1561

Medical Education

  • MD, Washington University School of Medicine
  • Residency, Children's Hospital of St. Louis
  • Fellowship, Univ. Washington School of Medicine
  • Fellowship, University Of Washington
  • Fellowship, Washington University School of Medicine

American Board Certifications

  • Clinical Biochemical Genetics, American Board of Medical Genetics and Genomics
  • Clinical Genetics and Genomics, American Board of Medical Genetics and Genomics
  • Pediatric Hematology-Oncology, American Board of Pediatrics

Accepted Insurance Plans

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.


The Sweetser laboratory investigates how leukemia and other cancers develop with the goal of developing novel, safer, and more effective therapies. We are investigating how the Groucho/TLE family of co-repressors function as potent tumor suppressors of acute myeloid leukemia and their roles in normal development and cell function. Knock-out mice for Tle1 and Tle4 have identified critical roles for these proteins in hematopoiesis, bone, lung, and brain development, as well as a critical role in limiting inflammation. We have defined critical inflammatory signaling pathways mediating cell proliferation and synergistic cross talk within the cancer niche. The laboratory is also using whole exome sequencing to characterize underlying cancer predisposition genes in patients with a variety of pediatric malignancies. As the MGH site director for the newly established HMS Undiagnosed Diseases Center and Chief of Medical Genetics and Metabolism at MGH, Dr. Sweetser is also leading a group of clinicians and researchers actively engaged in elucidating the underlying basis of a wide variety of human diseases.


Reviews: Comments and Ratings