How do doctors treat Klinefelter syndrome (KS)?

There is no cure for KS. Treatment focuses on you or your child’s individual symptoms and medical needs. Your care team will talk with you to create an individualized treatment plan. This will often include being seen by different types of doctors including a clinical geneticist, an endocrinologist or a fertility specialist, and a developmental medicine specialist or a psychologist.

Medication and therapy options for KS can include the following:


  • Testosterone replacement therapy to help replace the testosterone the body does not make. You can meet with an endocrinologist (hormone doctor) to decide if this option is appropriate. Testosterone replacement therapy comes as a gel, patch or injection.
  • Surgery to remove extra breast tissue, if present
  • If you are an adult or your child is a teen who wants children in the future, fertility treatments can help improve the chances of having children.


  • Speech and language therapy to help children cope with speech delays or challenges
  • Physical therapy to build muscle strength
  • Occupational therapy to gain everyday skills for living and work
  • Behavioral therapy or counseling to cope with depression, anxiety or low self-esteem
  • Help in school to cope with learning challenges or disabilities
Rev. 9/2018