Child examined during appointment

Pediatric Liver and Biliary Disease Center

The Pediatric Liver and Biliary Disease Center at MassGeneral Hospital for Children diagnoses and treats infants, children and adolescents with diverse hepatic, biliary and pancreatic disorders.

Contact the Pediatric Liver and Biliary Disease Center : 888-644-3211

Request a Remote Second Opinion


The Pediatric Liver and Biliary Disease Center at MassGeneral Hospital for Children diagnoses and treats infants, children and adolescents with diverse hepatic, biliary and pancreatic disorders ranging from gall stones and infectious hepatitis to rare metabolic and autoimmune liver diseases.

We are a multidisciplinary program that draws on all of the specialists at MassGeneral Hospital for Children as well as Massachusetts General Hospital to provide focused, comprehensive outpatient and inpatient care. We lead in the application of current knowledge to clinical care and are at the forefront in research, finding new cures for disease. 

Working closely with the Mass General Center for Transplantation and Adult Hepatology, we comprise the medical component of the Pediatric Liver Transplant Program and oversee the care of pediatric patients who are waiting for a new liver as well as those who have undergone transplantation.

Our Neonatal Hepatology Program is a novel multidisciplinary program that draws on the expertise of several specialties, including Neonatology, Pediatric Hepatology, Pediatric Nutrition, Pediatric Surgery, Medical Genetics and Metabolism and Pediatric Imaging.

Reflecting the often-complex care of children with hepatobiliary disorders, our group works collaboratively with other pediatric specialists throughout MassGeneral Hospital for Children, including:

Photo of Dr. Uzma Shah in clinic with a patient
Dr. Uzma Shah in clinic with a patient
  • Hepatologists
  • Gastroenterologists
  • Pediatric surgeons
  • Transplant surgeons
  • Endoscopists
  • Interventional radiologists
  • Liver and vascular radiologists
  • Pathologists
  • Infectious disease specialists
  • Psychiatrists
  • Geneticists
  • Nurse practitioners and transplant coordinators
  • Nutritionists
  • Social workers
  • Child Life

As part of our program’s pancreatic component, we work with specialists in pulmonology, cystic fibrosis, immunology, genetics and pediatric surgery.

Hepatologists specializing in transplant medicine provide state-of-the-art care for patients before and after transplant as an integral part of the Liver Transplant Program.

Conditions Treated


All diseases involving the liver and the biliary system such as:

Dr. Stephen Hardy consulting with a patient and her father
Dr. Stephen Hardy consults with a patient and her father
  • Genetic/metabolic disease
  • Biliary atresia
  • Choledochal cysts
  • Gallstones
  • Sphincter of Oddi dysfunction
  • Infectious hepatitis
  • Autoimmune hepatitis
  • Neonatal jaundice
  • Primary sclerosing cholangitis
  • Cirrhosis
  • Hepatic masses
  • Non alcoholic fatty liver disease
  • Storage diseases
  • Cystic fibrosis
  • Mitochondrial hepatopathy
  • Liver failure
  • Toxin induced hepatitis/failure


  • Acute and chronic pancreatitis
  • Pancreatic cysts and tumors
  • Cystic fibrosis

MassGeneral Hospital for Children has been designated as a National Pancreas Foundation Center for the treatment and care of children with pancreatitis. This designation recognizes our physicians' expertise and the center's team approach to the diagnosis and treatment of pancreatitis and related conditions.

Meet the Team

Director, Pediatric Liver and Biliary Disease Center


Child Psychiatrist

Other Providers

Conditions & Diseases

  • Alcohol-Induced Liver Disease

    Alcohol-induced liver disease, as the name implies, is caused by excessive consumption of alcohol and is a common, but preventable, disease.

  • Alcoholic Hepatitis

    Hepatitis is the inflammation of the liver, resulting in liver cell damage and destruction. Alcoholic hepatitis is a complex problem and is a precursor to chronic liver disease and cirrhosis.

  • Autoimmune Hepatitis

    Hepatitis is the inflammation of the liver, resulting in liver cell damage and destruction. In autoimmune hepatitis, the body's own immune system destroys liver cells.

  • Biliary Cirrhosis / Bile Duct Cancer

    Biliary cirrhosis is a rare form of liver cirrhosis, caused by disease or defects of the bile ducts.

  • Cholangitis

    Cholangitis is an inflammation of the bile duct system that is usually related to a bacterial infection. The bile duct system is the drainage system that carries bile from the liver and gallbladder into the area of the small intestine called the duodenum. The infection may occur suddenly or may be chronic.

  • Cholecystitis

    Cholecystitis is an inflammation of the gallbladder wall and nearby abdominal lining. Cholecystitis is usually caused by a gallstone in the cystic duct, the duct that connects the gallbladder to the hepatic duct.

  • Chronic Liver Disease / Cirrhosis

    Chronic liver disease is marked by the gradual destruction of liver tissue over time. Several liver diseases fall under this category, including cirrhosis of the liver and fibrosis of the liver.

  • Congenital Liver Defects

    Congenital liver defects are rare liver diseases present at birth such as biliary atresia, when the bile ducts are absent or have developed abnormally, and choledochal cyst, a malformation of the hepatic duct that can obstruct flow of bile in infants.

  • Cystic Fibrosis

    Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive system. CF causes the body to produce thick, sticky mucus that leads to progressive lung infection and difficulty gaining weight.

  • Drug-Induced Hepatitis

    Hepatitis is the inflammation of the liver, resulting in liver cell damage and destruction. Drug-induced hepatitis is rare and is caused by toxic exposure to certain medications, vitamins, herbal remedies, or food supplements.

  • Gallstones

    Gallstones form when bile stored in the gallbladder hardens into stone-like material.

  • Hepatitis A

    Hepatitis A is a highly contagious and sometimes serious liver disease caused by the hepatitis A virus.

  • Hepatitis B

    Hepatitis B is a blood-borne microorganism transmitted by exposure to the hepatitis B virus through infectious body fluids.

  • Hepatitis C

    Hepatitis C (once called non-A, non-B hepatitis) is a liver disease caused by a recently identified blood-borne virus.

  • Hiatal Hernia

    A hiatal hernia occurs when the upper part of the stomach pushes up into the chest through a small opening in the diaphragm, the muscle that separates the stomach from the chest.

  • Obesity

    Obesity increases the risk for many diseases, especially heart disease, stroke, cancer, and diabetes.

  • Other Liver Disorders

    An autoimmune disorder is any reaction or attack of a person's immune system against its own organs and tissues.

  • Pancreatic Cancer

    Pancreatic cancer is the fourth most common cause of cancer death in men and women in the US. Pancreatic cancer occurs when malignant cells grow out of control.

  • Pancreatitis

    Pancreatitis is the inflammation of the pancreas. The inflammation may be sudden (acute) or ongoing (chronic).

  • Polycystic Kidney Disease

    Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts filled with fluid in the kidneys.

  • Pseudocysts of the Pancreas

    Pseudocysts of the pancreas are abnormal collections of fluid, dead tissue, pancreatic enzymes, and blood that can lead to a painful mass in the pancreas.

Patient Resources


  • FAC Spotlight: Matthew McGuinness - 10/23/2018, Mass General

    Matthew McGuinness joined the Family Advisory Council (FAC) at MGHfC after his daughter, Sophie, 12, received exceptional care for Alagille syndrome, a rare genetic condition that affects the liver, and a liver transplant. His input on the FAC helps other parents whose children receive care here.

  • MGHfC Introduces Neonatal Hepatology Program - 1/9/2018, Mass General

    MGHfC is pleased to announce the launch of the Neonatal Hepatology Program, a novel multidisciplinary program that allows for the careful evaluation and management of distinct and complex liver disease in newborns.

  • Access and New Appointment Center Celebrates 10 Years - 12/13/2016, Mass General

    The Access and New Appointment Center, which opened in December 2006, was designed to be a single-entry point for scheduling new patient appointments and registering new patients. Instead of calling multiple phone numbers and leaving voicemails, patients, families and providers can call one number and have their call answered every time. Since opening, staff have answered more than 300,000 calls and scheduled more than 100,000 new patient appointments.


Contact Us

Pediatric Liver and Biliary Disease Center

Yawkey Center for Outpatient Care

Suite 6B32 Fruit Street Boston, MA 02114
  • Near Public Transit
  • Accessible
  • Phone: 888-644-3211
  • Fax: 617-643-2384


  • 8:30 am - 5 pm, Monday to Friday

Liver Transplant Clinic

165 Cambridge Street
Phone: 617-724-1218 | Fax: 617-726-2167

To schedule an appointment with a MassGeneral for Children pediatric specialist, please call 888-644-3248 or complete our online appointment form to request an appointment.

Physicians may call 888-644-3211 or use the online referral form and the Access & New Appointment Center will call your patient within 1 business day.

Contact the Pediatric Liver and Biliary Disease Center : 888-644-3211

Request a Remote Second Opinion

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