About E Tessa Hedley-Whyte, MD, MBBS

Dr. E. Tessa Hedley-Whyte is Professor of Pathology specializing in neuropathology and a Principal Investigator in theMassachusetts Alzheimer's Disease Research Center. She is the author of over 150 research papers with topics ranging from pediatric neuropathology, particularly pituitary tumors, to Alzheimer’s disease. She is deeply involved at Harvard Medical School in medical education, assisting in the admission and evaluation of students, and shaping the medical curriculum.

To learn more about her contributions to the field of Pathology and to the Pathology Service at Massachusetts General Hospital, refer to Chapter 17, Neuropathology, from Keen Minds to Explore the Dark Continents of Disease, a book on the Department’s history.

Departments, Centers, & Programs:

Clinical Interests:



Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696
Phone: 617-726-5154
Phone: 617-724-1465
Fax: 617-724-1813

Medical Education

  • MBBS, Kings College @ University of Durham
  • MD, Newcastle University
  • Residency, Boston Children's Hospital
  • Fellowship, Children's Cancer Research Foundation

American Board Certifications

  • Anatomic Pathology, American Board of Pathology
  • Neuropathology, American Board of Pathology

Accepted Insurance Plans

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Dr. Hedley-Whyte is co-investigator of the Neuropathology Core of the Massachusetts Alzheimer's Disease Research Center (ADRC). The Core's mission is to conduct neuropathological examinations on brains submitted to the Harvard Brain Tissue Resource Center and distribute tissue to ADRC investigators. The ADRC includes investigators with expertise in neuropathology, morphometry, immunocytochemistry, microarray technology, gene chip applications, laser capture techniques and in situ hybridization, and brain banking procedures. With Dr. Matthew Frosch, we use procedures to enhance the value of the brain tissues to investigators whose specific research projects depend upon receiving carefully prepared and diagnosed tissue. Standardized protocols for tissue acquisition, and dissection procedures ensure complete and reproducible examinations across all cases. The Tissue Resource Center maintains a rich collection of paraffin blocks with frozen, and formalin-fixed tissue. Frozen tissue is available as small blocks, and thin whole coronal brain slices, in which all anatomical structures are clearly visible. Separate databases within the Harvard Brain Tissue Resource Center contain information on tissue availability, location, and investigator allocation.

Dr. Hedley-Whyte's other research interests include predictive histological markers of pituitary tumor behavior.