Results from a new study by investigators at Massachusetts General Hospital indicate that persistent genital arousal disorder can be caused by altered firing of nerves that carry sensations from the genitalia or by damage to the lowest parts of the spinal cord.
Departments, Centers, & Programs:
Neurology Associates - Nerve Unit
15 Parkman Street
Boston, MA 02114-3117
- MD, PhD, Albert Einstein College of Medicine
- Residency, New Jersey Medical School GME-UMDNJ
- Fellowship, The Johns Hopkins Hospital
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- Neurology, American Board of Psychiatry and Neurology
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Kelley M, Oaklander AL Association of small-fiber polyneuropathy with 3 previously unassociated rare missense SCN9A variants. Can J Pain, 2020;4:19-29, DOI: 10.1080/24740527.2020.1712652
Oaklander AL, Sharma S, Kessler K, Price BH. Persistent Genital Arousal Disorder: A special sense neuropathy. PAIN Reports, 2020.
Fridman V, Suriyanarayanan S, Novak P, David WS, Macklin E, McKenna-Yasek D, Walsh K, Aziz-Bose R, Oaklander AL, Brown RH, Hornemann T, Eichler F. Randomized Trial of L-Serine in Patients with Hereditary Sensory and Autonomic Neuropathy Type 1. Neurology, 2019;92:e1-e12. PMID: 30626650
Liu X#, Treister R#, Lang M#, Oaklander AL. IVIg for apparently autoimmune small-fiber polyneuropathy: First analysis of efficacy and safety. Therapeutic Advances in Neurological Disorders 2018;11:1-12. PMID: 29403541
* indicates shared first or last authorship, # indicates a formally mentored co-author
- Press Release
- Nov | 8 | 2017
An analysis of the medical records of patients treated at Massachusetts General Hospital for an often-mysterious condition involving damage to small nerve fibers supports the hypothesis that some cases are caused by autoimmune disease and also identifies the first effective treatment option.