Departments, Centers, & Programs:
55 Fruit Street
Boston, MA 02114-2696
MGH Waltham Allergy
52 Second Ave
Waltham, MA 02451
- MD, Northwestern University Medical School
- Residency, Duke University Medical Center
- Fellowship, Washington University School of Medicine St. Louis
American Board Certifications
- Internal Medicine, American Board of Internal Medicine
- Diagnostic Laboratory Immunology, American Board of Internal Medicine
- Allergy & Immunology, American Board of Allergy and Immunology
Accepted Insurance Plans
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
My laboratory is investigating the pathogenesis of chronic rhinosinusitis (CRS). We are examining whether the nasal/sinus epithelium of CRS patients is lacking in the ability to produce innate immune factors involved in defense against infection. We are examining nasal/sinus tissue samples as well as cultured epithelial cells. We are currently examining innate immune and inflammatory gene expression in nasal/sinus tissues using broad-based mRNA expression profiling. These studies are supported by a grant from the Flight Attendants Medical Research Institute (FAMRI) as well as a Harvard Catalyst Grant. It is our hope that these studies will lead to a greater understanding of CRS pathogenesis and help identify novel therapies.
I am also a co-investigator with Dr. Andrew Luster in an NIH funded project aimed at understanding the role of chemokines and Th2 cellular trafficking in asthma. I am responsible for recruitment and preparation of subjects for bronchoscopy and bronchoalveolar lavage. Each subject's allergic sensitivity to house dust mite and cat allergen is first determined by skin test titration. Subsequently, each subject undergoes bronchoscopy with seqmental allergen challenge followed 24 hours later by bronchoscopy with bronchoalveolar lavage. We are also comparing the inflammatory response to allergen in allergic nonasthmatics versus allergic asthmatics to determine whether cellular inflammation can account for the asthmatic response. It is our hope that these studies will help elucidate the mechanisms that control the asthmatic response and the link between allergic airway inflammation and airway hyperresponsiveness.
- Hamilos DL, Baroody FM, editors. Chronic Rhinosinusitis: Pathogenesis and Medical Management. New York: Informa Healthcare; 2007.
- Banerji A, Piccirillo JF, Thawley SE, Levitt RG, Schechtman KB, Kramper MA, Hamilos DL. Chronic rhinosinusitis patients with polyps or polypoid mucosa have a greater burden of illness. Am J Rhinology 2007;21:19-26.
- Hamilos DL, D'Urzo A, Levy RJ, Marcus M, Tripp K, Parsey M, Baumgartner RA, McVicar WK. Long-term safety study of levalbuterol administered via metered-dose inhaler in patients with asthma. Ann Allergy Asthma Immunol. 2007;99(6):540-8.
- Yamin M, Holbrook EH, Gray ST, Harold R, Busaba N, Sridhar A, Powell KJ, Hamilos DL Cigarette smoke combined with Toll-like receptor 3 (TLR3) signaling triggers exaggerated epithelial RANTES/CCL5 expression in chronic rhinosinusitis (CRS). J Allergy Clin Immunol 2008; 122:1145-1153. PMID: 18986692
- Hamilos DL. Allergic fungal rhinitis and rhinosinusitis. Proc Am Thorac Soc. 2010;7(3):245-52.