About James Chodosh, MD, MPH

Dr. James Chodosh is a clinician scientist internationally known and respected for his work on molecular virology, viral genomics, and viral pathogenesis. In addition to serving as the Associate Director of the Cornea and Refractive Surgery Service, he directs Boston Keratoprosthesis Programs and serves as Vice Chair for Ophthalmology Education at Harvard Medical School and Associate Chief of Ophthalmology Education at Mass. Eye and Ear. His clinical interests include ocular infections, chemical burns, Stevens Johnson syndrome, and keratoprosthesis surgery.

Dr. Chodosh attended medical school at Baylor College of Medicine, where he also completed his residency. He served his fellowship in Corneal and External Diseases and Surgery at Bascom Palmer Eye Institute.

His laboratory leads the field of ocular adenoviral pathogenesis and has contributed greatly to the prevention and treatment of vision loss due to corneal infection, inflammation, and scarring. Dr. Chodosh is also committed to promoting the use of the Boston Keratoprosthesis (KPro) worldwide, and has performed and assisted with artificial cornea implantation surgery in India, Italy, England, Israel, and Chile. Recently, he achieved FDA approval for the Lucia keratoprosthesis, a lower-cost device to treat corneal blindness, including in economically deprived nations. 

Dr. Chodosh is a committed teacher and mentor and is Director of the Cornea, Refractive Surgery, and External Disease Fellowship. He is also a Member of the PhD Program in Virology at Harvard Medical School. He has served on graduate student committees, trained postdoctoral fellows, predoctoral fellows, and residents in research, and taught several graduate courses. He has mentored over 60 clinical cornea fellows, many of whom now hold academic positions. He is also the author over 275 articles and book chapters, and is a four-time award recipient from Research to Prevent Blindness. 

Departments, Centers, & Programs:

Clinical Interests:



Mass. Eye and Ear
243 Charles St.
Boston, MA 02114
Phone: 617-523-7900

Medical Education

  • MD, Baylor College of Medicine
  • Residency, Baylor College of Medicine
  • Fellowship, Bascom Palmer Eye Institute

American Board Certifications

  • Ophthalmology, American Board of Ophthalmology

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Dr. Chodosh illuminates the molecular pathogenesis of adenoviral ocular infection and restores vision to those with blinding, autoimmune, corneal diseases through expanding the clinical scope of the Boston Keratoprosthesis (B-KPro), a unique corneal substitute developed by Dr. Claes H. Dohlman. His group is the worldwide leader inadenoviral ocular pathogenesis. Dr. Chodosh studies the viruses that cause the most severe form of pink eye, known as epidemic keratoconjunctivitis (EKC). In particular, his group generated the first whole genome sequence for the adenoviruses that cause EKC, created the first mouse model of adenovirus keratitis, and pioneered the cornea as a model system in which to study the role of tissue fibroblasts in innate immune responses to infection.


  • 1. Jakobiec FA, Hanbazazh M, Cortes Barrantes P, Chodosh J. Adult Primary Capillary Hemangioma of the Sclera: A Previously Undescribed Entity With a Review of Epibulbar Vascular Lesions. Ophthalmic Plast Reconstr Surg. 2019 Dec 31. 

    2. Ung L, Wang Y, Vangel M, Davies EC, Gardiner M, Bispo PJM, Gilmore MS, Chodosh J. Validation of a Comprehensive Clinical Algorithm for the Assessment and Treatment of Microbial Keratitis. Am J Ophthalmol. 2019 Dec 30.

    3. Jonas RA, Ung L, Rajaiya J, Chodosh J. Mystery Eye: Human Adenovirus and the Enigma of Epidemic Keratoconjunctivitis. Prog Retin Eye Res. 2019 Dec 28; 100826.

    4. Ung L, Bispo PJM, Bryan NC, Andre C, Chodosh J, Gilmore MS. The Best of All Worlds: Streptococcus pneumoniae Conjunctivitis through the Lens of Community Ecology and Microbial Biogeography. Microorganisms. 2019 Dec 25; 8(1). 

    5. Mohamed Ismail A, Zhou X, Dyer DW, Seto D, Rajaiya J, Chodosh J. Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D. FEBS Lett. 2019 Dec; 593(24):3583-3608.

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