New Blood-Based Monitoring of Prostate Cancer
David Miyamoto, MD, PhD and his team published a new method to detect and characterize circulating tumor cells in the blood more accurately with important implications for treatment of prostate cancer
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David Miyamoto, MD, PhD is an Assistant Professor of Radiation Oncology at Harvard Medical School, an attending radiation oncologist at the Massachusetts General Hospital, an Investigator in the Mass General Center for Cancer Research, and an Associate Member of the Broad Institute of Harvard and MIT. Dr. Miyamoto received his undergraduate degree in Chemistry from Harvard College, MD from Harvard Medical School, and PhD in Cell Biology from Harvard University. He completed his internship in Internal Medicine at the Brigham & Women's Hospital and his residency in the Harvard Radiation Oncology Program. Dr. Miyamoto is a board-certified radiation oncologist specializing in genitourinary malignancies who sees patients in the Bertucci Center for Genitourinary Cancers at the Mass General Cancer Center and the Department of Radiation Oncology. His research efforts focus on the development of novel biomarkers to guide prostate cancer and bladder cancer therapy and improve the individualized care of each patient. He has authored more than 40 publications in peer-reviewed scientific journals including Science, Cell, and Cancer Discovery. His research has been supported by the Prostate Cancer Foundation, Department of Defense, National Cancer Institute, and the Dana Farber/Harvard Cancer Center.
Departments, Centers, & Programs:
Clinical Interests:
Treats:
Clark Center for Radiation Oncology
100 Blossom Street
Boston, MA 02114-2606
Phone: 617-726-5866
Fax: 617-726-3603
Medical Education
American Board Certifications
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The Miyamoto laboratory focuses on the discovery and development of novel biomarkers to guide the personalized treatment of patients with prostate cancer and bladder cancer. We focus on two general classes of biomarkers, namely those based on the molecular profiles of tumor biopsies, and those based on circulating tumors cells (CTCs) in the blood that can be sampled non-invasively and repeatedly. By analyzing these patient-derived specimens, we have identified new molecular predictors of response to therapy and potential mechanisms of treatment resistance. Our overall aim is to develop tools for “real-time precision medicine” to probe the molecular signatures of cancers as they evolve over time, and to guide the precise and rational selection of appropriate therapies for each individual patient with cancer.
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Mass General is the #1 Research Hospital in America and the only hospital to be recognized in all 16 specialties assessed by U.S. News & World Report.
David Miyamoto, MD, PhD and his team published a new method to detect and characterize circulating tumor cells in the blood more accurately with important implications for treatment of prostate cancer
Drs. Henning Willers and David Miyamoto were recognized with a $150,000 grant to support their research proposal on investigating mechanisms of DNA repair after proton radiation.