Overview

The mission of the food allergy center is to provide the best possible care through multidisciplinary care and research.

Departments

Pediatrics

Centers & Specialties

MassGeneral Hospital for Children

Clinical Interests
  • Food allergy
  • Eosinophilic gastrointestinal disease
  • Eczema (atopic dermatitis)
  • Asthma
  • Immunotherapy
Medical Education
  • MD, PhD, New York University School of Medicine
  • Residency, Montefiore Hospital & Medical Center
  • Fellowship, Mount Sinai Hospital Medical Center
Locations
  • Boston: Massachusetts General Hospital
Existing Patients
Patient Gateway
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • BMC HealthNet Mass Health MCO/ACO
  • Cigna (PAL #'s)
  • Commonwealth Care Alliance
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
  • Well Sense Pediatrics

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Pediatric
Provider Gender
Male

Biography

Dr. Shreffler received his MD and PhD degrees from New York University and his Pediatrics training at the Albert Einstein College of Medicine. He completed his fellowship in Allergy & Immunology at the Mount Sinai School of Medicine in 2003 where he was mentored by Drs. Hugh Sampson and Lloyd Mayer, and established himself as a researcher of immune mechanisms of food allergy and asthma. He joined Massachusetts General Hospital and Harvard Medical School in late 2009 to establish a new translational research and clinical care center focused on food allergy, and he became Division Chief of Pediatric Allergy and Immunology in 2011.

The Food Allergy Center at MGH is a highly integrated research and clinical program to better understand the pathogenic mechanisms of food allergy and asthma and provide the best current and future care. The Shreffler laboratory focuses on the characterization of cellular and humoral immune response to dietary antigens and the mechanisms of allergen-induced Th2 sensitization and oral tolerance. Areas of active investigation include 1) the mechanisms of allergenic dendritic cell (DC) activation by allergens and the DC signals that induce Th2 differentiation; 2) the role of regulatory T cells in natural and immunotherapy-induced oral tolerance; 3) the role of IgE diversity and basophil activation and their regulation in both the effector response and in adaptive immune deviation in the context of food allergy and asthma.

 

Dr. Shreffler has authored more than 70 papers, maintained continuous NIH and other research funding since 2007, served on the editorial board of the Journal of Allergy and Clinical Immunology and as reviewer for numerous journals and grant study sections / committees. He was elected a Fellow of the AAAAI in 2009.

 

Research & Publications

Research Summary

The Shreffler laboratory focuses on the characterization of cellular and humoral immune response to dietary antigens and the mechanisms of allergen-induced Th2 sensitization and oral tolerance. Areas of active investigation include 1) the mechanisms of allergenic dendritic cell (DC) activation by allergens and the DC signals that induce Th2 differentiation; 2) the role of regulatory T cells in natural and immunotherapy-induced oral tolerance; 3) the role of IgE diversity and basophil activation and their regulation in both the effector response and in adaptive immune deviation in the context of food allergy and asthma. We primarily work with human samples, often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens.

Working together with numerous collaborators including from the Consortium for Food Allergy Research , the Inner City Asthma Consortium and our own newly established Food Allergy Center at MGH, we are adapting the use of polychromatic flow cytometry, peptide microarray-based humoral immune profiling and systems biology approaches to uniquely characterize the phenotype and function of allergen-specific T and B cell responses and the regulations of effector cells in pediatric food allergy and asthma.

Also important is the effort to understand why some food proteins are potent allergens. In other words, what are the mechanisms that influence early immune fate decisions to allergens and the intrinsic properties of those allergens that facilitate an allergic response. We are studying this in human and murine model systems.

Publications

View my most recent publications at PubMed

see PubMed link.

News & Events

Contact

Division of Pediatric Allergy and Immunology
55 Fruit Street
CPZS-5-523
Boston, MA 02114-3108
Phone 1: 617-726-8707
Phone 2: 617-726-6147
Fax: 617-724-2803