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Third Rock Ventures (TRV) is a premier life sciences venture capital firm based in Boston. Its mission is to discover, launch, and build exceptional life science companies with passionate entrepreneurs in areas of disruptive science to make a meaningful difference in the lives of patients. With over $1.3 billion in capital raised and over 38 companies started since inception in 2007, TRV has a stellar track record of success in delivering breakthrough therapies, devices and diagnostics to meet unmet patient needs. Their innovative and hands-on approach to discovering, launching, building and operating promising life science companies is highly differentiated, and they have assembled an entrepreneurial team with deep expertise and proven experience in building and running some of the most respected and successful life sciences companies. The firm has a strong interest in topics such as glial biology and synaptic pruning.

Massachusetts General Hospital (MGH) is one of the largest tertiary academic hospitals in the country with a rich and thriving clinical and research environment encompassing multiple specialties across several disciplines. The MGH Neurology department consists of more than 230 physicians and scientists, many of whom have gained national and international recognition for their clinical and/or research efforts. The mission of the department is to find new treatments and cures that eliminate the devastating impact of neurological disorders. This is supported through collaborative programs such as the Center for Human Genetic Research (HGR), the Neurological Clinical Research Institute (NCRI) and the Center for Rare Neurological Diseases (CDRN).

The Third Rock-MGH Neuroscience Fellowship is a 2-year fellowship program focused on discovering, launching, and building important companies that develop breakthrough products for patients with neurologic and psychiatric disorders, and reinforce a new paradigm of industry-academic partnership to pioneer new treatments in neurological diseases.

Fellows will acquire unique skills by:

  • Working side-by-side with accomplished entrepreneurs, scientists, venture capitalists, and operators to discover new company concepts and academic innovations
  • Receiving great training for academics to start companies or know how to bring their ideas into a product
  • Contributing to the unique company Discovery model at TRV, which continually evaluates key areas of science and technology and combines them with clear unmet medical needs
  • Leading the founding and building of a new company from idea to company launch
  • Identifying, engaging and recruiting scientific thought leaders and potential scientific founders
  • Learning to deliver results in a high energy, informal culture that thrives on “creative chaos”
  • Leveraging new biological insights towards commercial applications in the neurosciences
  • Building your network in life sciences – both within TRV and MGH and its expansive network

Fellows Responsibilities:

Opportunity analysis

  • Member/or leader of a Discovery project team performing the company discovery, launching, building and due diligence activities required in making investment decisions
  • Evaluate the scientific, technical and clinical insights within a translational neuroscience environment at MGH
  • Identify promising scientific research in neurological and/or rare diseases with potential to form the basis of a start-up company
  • Assess the regulatory, IP and commercial landscape of the science and/or platform technology
  • Evaluate new neurological or rare disease indications, relevant biomarker and outcome measures in view of potential new treatments
  • Work with Third Rock teams of venture capitalists and entrepreneurs on operational and strategic issues for future Third Rock portfolio companies
  • Perform Scientific ( e.g. preclinical) and clinical data analysis at CHGR, NCRI and CDRN
  • Define preclinical (disease relevant model systems, identifying biological targets) and clinical projects (optimizing outcome measures for disease indication)
  • Prepare documentation and drive the internal review process which will result in Go/No Go financing decisions for new companies
  • Screen business plans and investment proposals
  • Generate and analyze financial models

Firm operations

  • Generate new investment ideas for the Company by monitoring the scientific and business press (i.e. prepare and present Discovery topics/plans)
  • Gather and analyze market intelligence on the life science deal and financing environment via research reports, press, databases and other sources
  • Execute on new company investment ideas
  • Attract potential new hires and assist in recruiting the best and brightest to TRV


Ideal Qualifications:

  • Degree candidate or graduate degree in life sciences required (Ph.D. or M.D.), including faculty with research experience and a strong translational focus in a life sciences discipline; M.D./ Ph.D.’s will be favorably considered
  • If an M.D., minimum of 2 years residency training preferred
  • Broad thinker who has the ability to quickly get up speed in areas outside his/her scientific expertise
  • Entrepreneurial and self-directed work style; flexible and comfortable with ambiguity
  • Ability to work in an environment of gifted individuals working together as a team
  • Must have demonstrated strength in scientific research and data analysis
  • Strong presentation and communication skills; candidate should feel comfortable presenting to groups

How to Apply

Applying for a position:

  • Resume/CV along with publication list
  • Two-page letter of intent
  • Two reference letters from current or recent supervisors
  • NIH Other support report
  • Non US citizens must include proof of visa
  • Send the application package as one PDF to feichler@partners.org

Candidates will be selected by a joint selection committee comprised of members from both MGH and TRV.

  • Application due date: Rolling
  • Award announcement date: Rolling
  • Fellowship start date: Rolling

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