Photo of Jan (Jan) Leslie Shifren, MD

Jan (Jan) Leslie Shifren, MD

  • Director, Massachusetts General Hospital Midlife Women's Health Center
  • Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School


Accepting New Patients

Request a fertility appointment


Jan Shifren, MD, is a reproductive endocrinologist and infertility specialist at Massachusetts General Hospital and a Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. She directs the Mass General Midlife Women's Health Center.


Obstetrics & Gynecology

Clinical Interests
  • Assisted reproductive technology and invitro fertilization (IVF)
  • Menopause
  • Infertility - female
  • Infertility - male
  • Female sexual dysfunction
Medical Education
  • MD, Harvard Medical School
  • Residency, Brigham and Women's Hospital
  • Fellowship, UC San Francisco
Board Certifications
  • Obstetrics & Gynecology
  • Reproductive Endo. & Infertility
  • Boston: Massachusetts General Hospital
  • Newton: Newton-Wellesley Hospital
Existing Patients
Patient Gateway
Insurances Accepted
  • Aetna Health Inc.
  • AllWays Health (NHP) - ACD
  • AllWays Health (NHP) - PBO
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • BMC HealthNet Mass Health MCO/ACO
  • Cigna (PAL #'s)
  • Commonwealth Care Alliance
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Maine Community Health Options (MCHO)
  • MassHealth
  • Medicare
  • Medicare - ACD
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - New York
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
  • Well Sense Pediatrics

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Provider Gender


Jan Shifren, MD is a Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School. She is a reproductive endocrinologist at the Mass General Fertility Center and Directs the Midlife Women's Health Center. She attended Yale College and Harvard Medical School. She completed her residency in Ob/Gyn at Brigham & Women's Hospital and Mass General and a fellowship in Reproductive Endocrinology and Infertility at the University of California, San Francisco.

Dr. Shifren currently divides her time among research, teaching and patient care. Her clinical interests include caring for women with infertility, recurrent pregnancy loss, premature ovarian insufficiency and concerns regarding menopause. She is an active member of the Fertility Center, participating in the care of women requiring assisted reproductive technologies, including ovulation induction therapies and IVF. Her research focuses on menopause, including the effects of estrogens, androgens and alternative therapies on menopausal symptoms, mood and sexual function. She has published numerous articles, abstracts and book chapters and has delivered national and international presentations on menopause, hormone therapy, androgens for women and female sexual function.

Research & Publications

Research Summary

View my most recent research

Dr. Shifren's research focuses on menopause, including the effects of estrogens, androgens and alternative therapies on menopausal symptoms, mood, and sexual function. Dr. Shifren has served as Principal Investigator and Co-Investigator for several important studies related to the menopause and female sexuality. She has published numerous articles, abstracts, and book chapters and has delivered national and international presentations on menopause, hormone therapy, androgens for women, and female sexual function.

Dr. Shifren is active in numerous professional societies, including the North American Menopause Society, American College of Obstetricians and Gynecologists, American Society of Reproductive Medicine, Society of Reproductive Endocrinologists, Endocrine Society, and Society for Gynecologic Investigation. She serves on the Editorial Boards of Menopause and Ob.Gyn News,. She is an ad hoc reviewer for Menopause, Fertility and Sterility, the New England Journal of Medicine, and the Journal of Clinical Endocrinology and Metabolism, among others.


View my most recent publications at PubMed

Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000; 343:682-8. Shifren JL, Ferrari, N. A better sex life. Newsweek 2004; 143 (19): 86-7.

Shifren JL, Davis SR, Moreau M, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the Intimate NM1 study. Menopause 2006; 13(5):770-9.

Shifren JL, Schiff I. Menopause. In: Berek JS, editor. Berek & Nova's Gynecology (Fourteenth Edition). Philadelphia: Lippincott Williams & Wilkins; 2007. p. 1323-40.

Shifren JL, Desindes S, McIlwain M, et al. A Randomized, open label, crossover study comparing the effects of transdermal vs. oral estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause 2007;14(6):985-94.

Shifren JL, Monz BU, Russo PA, et al. Sexual problems and distress in United States women: prevalence and correlates. Obstet Gynecol 2008;112:970-8.

Shifren JL, Author; Barbieri RL, Section Editor; Falk SJ, Deputy Editor. Sexual dysfunction in women: Management. Up to Date Online. Topic updated: Aug 31, 2015.

Shifren JL, Schlam Edelman J, Schiff I. Hormone therapy and alternative therapies for menopause. Clinical Updates in Women’s Health Care. Washington, DC: The American College of Obstetricians and Gynecologists; 2015; XIV(4):1-125.


News & Events


Vincent Reproductive Medicine & IVF
55 Fruit Street
Yawkey Center for Outpatient Care
Boston, MA 02114-2696
Phone: 617-726-8868
Fax: 617-724-8882
Partners Reproductive Medicine Center at NWH
2000 Washington Street
Newton, MA 02462
Phone: 617-243-5200
Fax: 617-243-6922

Back to Top